ID A0A6H3A750_BACAN Unreviewed; 764 AA. AC A0A6H3A750; DT 07-OCT-2020, integrated into UniProtKB/TrEMBL. DT 07-OCT-2020, sequence version 1. DT 22-FEB-2023, entry version 9. DE SubName: Full=Protective antigen {ECO:0000313|EMBL:BAR79119.1}; GN ORFNames=BASH2_pXO10148 {ECO:0000313|EMBL:BAR79119.1}; OS Bacillus anthracis. OG Plasmid pXO1 {ECO:0000313|EMBL:BAR79119.1, OG ECO:0000313|Proteomes:UP000217643}. OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus; OC Bacillus cereus group. OX NCBI_TaxID=1392 {ECO:0000313|EMBL:BAR79119.1, ECO:0000313|Proteomes:UP000217643}; RN [1] {ECO:0000313|EMBL:BAR79119.1, ECO:0000313|Proteomes:UP000217643} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Shikan-NIID {ECO:0000313|EMBL:BAR79119.1, RC ECO:0000313|Proteomes:UP000217643}; RC PLASMID=pXO1 {ECO:0000313|EMBL:BAR79119.1, RC ECO:0000313|Proteomes:UP000217643}; RA Okutani A., Morikawa S., Inoue S.; RT "Bacillus anthracis whole genome sequence."; RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP014834; BAR79119.1; -; Genomic_DNA. DR RefSeq; NP_052806.1; NC_001496.1. DR RefSeq; WP_000746486.1; NZ_SDEF01000130.1. DR AlphaFoldDB; A0A6H3A750; -. DR SMR; A0A6H3A750; -. DR GeneID; 45025512; -. DR PATRIC; fig|1392.233.peg.5879; -. DR OMA; YINANVR; -. DR Proteomes; UP000217643; Plasmid pXO1. DR GO; GO:0005576; C:extracellular region; IEA:InterPro. DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro. DR Gene3D; 2.60.40.810; -; 1. DR Gene3D; 3.10.20.110; -; 1. DR Gene3D; 2.60.120.240; Protective antigen, heptamerisation domain; 1. DR Gene3D; 3.90.182.10; Toxin - Anthrax Protective Antigen;domain 1; 1. DR InterPro; IPR003896; Bacterial_exotoxin_B. DR InterPro; IPR035331; Binary_toxB_3. DR InterPro; IPR037524; PA14/GLEYA. DR InterPro; IPR011658; PA14_dom. DR InterPro; IPR035088; PA_Ca-bd. DR InterPro; IPR027441; PA_dom4. DR InterPro; IPR027439; PA_heptamer_dom. DR InterPro; IPR037149; PA_heptamer_dom_sf. DR Pfam; PF03495; Binary_toxB; 1. DR Pfam; PF17475; Binary_toxB_2; 1. DR Pfam; PF17476; Binary_toxB_3; 1. DR Pfam; PF07691; PA14; 1. DR PRINTS; PR01391; BINARYTOXINB. DR SMART; SM00758; PA14; 1. DR SUPFAM; SSF56988; Anthrax protective antigen; 1. DR PROSITE; PS51820; PA14; 1. PE 4: Predicted; KW Plasmid {ECO:0000313|EMBL:BAR79119.1}; Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..29 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 30..764 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5026915901" FT DOMAIN 43..179 FT /note="PA14" FT /evidence="ECO:0000259|PROSITE:PS51820" FT REGION 176..214 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 302..333 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 302..331 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 764 AA; 85811 MW; 3AE1EFBF48FAA03F CRC64; MKKRKVLIPL MALSTILVSS TGNLEVIQAE VKQENRLLNE SESSSQGLLG YYFSDLNFQA PMVVTSSTTG DLSIPSSELE NIPSENQYFQ SAIWSGFIKV KKSDEYTFAT SADNHVTMWV DDQEVINKAS NSNKIRLEKG RLYQIKIQYQ RENPTEKGLD FKLYWTDSQN KKEVISSDNL QLPELKQKSS NSRKKRSTSA GPTVPDRDND GIPDSLEVEG YTVDVKNKRT FLSPWISNIH EKKGLTKYKS SPEKWSTASD PYSDFEKVTG RIDKNVSPEA RHPLVAAYPI VHVDMENIIL SKNEDQSTQN TDSQTRTISK NTSTSRTHTS EVHGNAEVHA SFFDIGGSVS AGFSNSNSST VAIDHSLSLA GERTWAETMG LNTADTARLN ANIRYVNTGT APIYNVLPTT SLVLGKNQTL ATIKAKENQL SQILAPNNYY PSKNLAPIAL NAQDDFSSTP ITMNYNQFLE LEKTKQLRLD TDQVYGNIAT YNFENGRVRV DTGSNWSEVL PQIQETTARI IFNGKDLNLV ERRIAAVNPS DPLETTKPDM TLKEALKIAF GFNEPNGNLQ YQGKDITEFD FNFDQQTSQN IKNQLAELNA TNIYTVLDKI KLNAKMNILI RDKRFHYDRN NIAVGADESV VKEAHREVIN SSTEGLLLNI DKDIRKILSG YIVEIEDTEG LKEVINDRYD MLNISSLRQD GKTFIDFKKY NDKLPLYISN PNYKVNVYAV TKENTIINPS ENGDTSTNGI KKILIFSKKG YEIG //