ID   A0A6H1PGK5_9INFA        Unreviewed;       670 AA.
AC   A0A6H1PGK5;
DT   12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT   12-AUG-2020, sequence version 1.
DT   24-JUL-2024, entry version 8.
DE   RecName: Full=Polymerase basic protein 2 {ECO:0000256|ARBA:ARBA00014261};
DE   AltName: Full=RNA-directed RNA polymerase subunit P3 {ECO:0000256|ARBA:ARBA00030401};
DE   Flags: Fragment;
GN   Name=PB2 {ECO:0000313|EMBL:QIZ12786.1};
OS   Influenza A virus.
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus;
OC   Alphainfluenzavirus influenzae.
OX   NCBI_TaxID=11320 {ECO:0000313|EMBL:QIZ12786.1};
RN   [1] {ECO:0000313|EMBL:QIZ12786.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A/Green-winged teal/Mexico/PB2_UIFMVZ80/2016
RC   {ECO:0000313|EMBL:QIZ12786.1};
RA   Mateus-Anzola J., Gaytan-Cruz L., Montoya-Carrillo C.,
RA   Sanchez-Betancourt J., Zarza H., Segura-Velazquez R., Ojeda-Flores R.;
RT   "Molecular identification and phylogenetic characterization of influenza A
RT   virus in wild ducks at a wildlife - livestock interface in Mexico.";
RL   Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Host mitochondrion
CC       {ECO:0000256|ARBA:ARBA00004181}. Mitochondrion
CC       {ECO:0000256|ARBA:ARBA00004173}.
CC   -!- SIMILARITY: Belongs to the influenza viruses PB2 family.
CC       {ECO:0000256|ARBA:ARBA00008660}.
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DR   EMBL; MT325966; QIZ12786.1; -; Viral_cRNA.
DR   GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0044423; C:virion component; IEA:UniProtKB-KW.
DR   GO; GO:0006370; P:7-methylguanosine mRNA capping; IEA:UniProtKB-KW.
DR   GO; GO:0075526; P:cap snatching; IEA:UniProtKB-KW.
DR   GO; GO:0039523; P:symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity; IEA:UniProtKB-KW.
DR   InterPro; IPR049110; Flu_PB2_2nd.
DR   InterPro; IPR049114; Flu_PB2_6th.
DR   InterPro; IPR048298; Flu_PB2_CAP-bd.
DR   InterPro; IPR049111; Flu_PB2_middle.
DR   InterPro; IPR049106; Flu_PB2_N.
DR   InterPro; IPR049113; PB2_helical.
DR   Pfam; PF20947; Flu_PB2_1st; 1.
DR   Pfam; PF20948; Flu_PB2_2nd; 1.
DR   Pfam; PF20949; Flu_PB2_3rd; 1.
DR   Pfam; PF20950; Flu_PB2_4th; 1.
DR   Pfam; PF00604; Flu_PB2_5th; 1.
DR   Pfam; PF20951; Flu_PB2_6th; 1.
PE   3: Inferred from homology;
KW   Cap snatching {ECO:0000256|ARBA:ARBA00022715};
KW   Eukaryotic host gene expression shutoff by virus
KW   {ECO:0000256|ARBA:ARBA00023103};
KW   Eukaryotic host transcription shutoff by virus
KW   {ECO:0000256|ARBA:ARBA00022731};
KW   Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00023103};
KW   Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00023103};
KW   Inhibition of host RNA polymerase II by virus
KW   {ECO:0000256|ARBA:ARBA00023103};
KW   mRNA capping {ECO:0000256|ARBA:ARBA00023042};
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW   Viral transcription {ECO:0000256|ARBA:ARBA00023314};
KW   Virion {ECO:0000256|ARBA:ARBA00022844}.
FT   DOMAIN          1..36
FT                   /note="Influenza RNA polymerase PB2 N-terminal region"
FT                   /evidence="ECO:0000259|Pfam:PF20947"
FT   DOMAIN          37..104
FT                   /note="Influenza RNA polymerase PB2 second"
FT                   /evidence="ECO:0000259|Pfam:PF20948"
FT   DOMAIN          106..248
FT                   /note="Influenza RNA polymerase PB2 middle"
FT                   /evidence="ECO:0000259|Pfam:PF20949"
FT   DOMAIN          250..319
FT                   /note="Polymerase basic protein 2 helical"
FT                   /evidence="ECO:0000259|Pfam:PF20950"
FT   DOMAIN          320..530
FT                   /note="Influenza RNA polymerase PB2 CAP binding"
FT                   /evidence="ECO:0000259|Pfam:PF00604"
FT   DOMAIN          531..670
FT                   /note="Influenza RNA polymerase PB2 sixth"
FT                   /evidence="ECO:0000259|Pfam:PF20951"
FT   NON_TER         670
FT                   /evidence="ECO:0000313|EMBL:QIZ12786.1"
SQ   SEQUENCE   670 AA;  76424 MW;  93C14302B56F266B CRC64;
     MERIKELRDL MSQSRTREIL TKTTVDHMAI IKKYTSGRQE KNPALRMKWM MAMKYPITAD
     KKIMEMIPER NEQGQTLWSK TNDAGSDRVM VSPLAVTWWN RNGPTTNTVH YPKVYRTYFE
     KVERLKHGTF GPVHFRNQVK IRRRVDINPG HADLSAKEAQ DVIMEVVFPN EVGARILTSE
     SQLTITKEKK EELQYCKIAP LMVAYMLERE LVRKTRFLPV AGGTSSVYIE VLHLTQGTCW
     EQMYTPGGGV RNDDVDQSLI IAARNIVRRA TVSADPLASL LEMCHSTQIG GIKMVDILRQ
     NPTEEQAVDI CKAAMGLRIS SSFSFGGFTF KRTSGSSVKK EEEVLTGNLQ TLKIRVHEGY
     EEFTMVGRRA TAILRKATRR LIQLIVSGRD EQSIAEAIIV AMVFSQEDCM IKAVRGDLNF
     VNRANQRLNP MHQLLRHFQK DAKVLFQNWG IEPIDNVMGM IGILSDMTPS TEMSLRGIRV
     SKMGVDEYSS TERVVVSIDR FLRVRDQRGN VLLSPEEVSE TQGTEKLTIT YSSSMMWEIN
     GPESVLVNTY QWIIRNWETV KIQWSQDPTM LYNKMEFEPF QSLVPKAARS QYSGFVRTLF
     QQMRDVLGTF DTVQIIKLLP FASAPPEQSR MQFSSLTVNV RGSGMRILVR GNSPVFNYNK
     ATKRLTVLGK
//