ID A0A6H0QSW1_HEV Unreviewed; 116 AA. AC A0A6H0QSW1; DT 12-AUG-2020, integrated into UniProtKB/TrEMBL. DT 12-AUG-2020, sequence version 1. DT 02-DEC-2020, entry version 3. DE RecName: Full=Protein ORF2 {ECO:0000256|ARBA:ARBA00021182, ECO:0000256|RuleBase:RU363023}; DE Flags: Fragment; OS Hepatitis E virus (HEV). OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes; OC Hepelivirales; Hepeviridae; Orthohepevirus; Orthohepevirus A. OX NCBI_TaxID=12461 {ECO:0000313|EMBL:QIV64897.1}; OH NCBI_TaxID=69079; Bandicota bengalensis (lesser bandicoot rat). OH NCBI_TaxID=9481; Callithrix. OH NCBI_TaxID=9536; Cercopithecus hamlyni (Owl-faced monkey) (Hamlyn's monkey). OH NCBI_TaxID=9534; Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops). OH NCBI_TaxID=9031; Gallus gallus (Chicken). OH NCBI_TaxID=9606; Homo sapiens (Human). OH NCBI_TaxID=9539; Macaca (macaques). OH NCBI_TaxID=10090; Mus musculus (Mouse). OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee). OH NCBI_TaxID=9520; Saimiri (squirrel monkeys). OH NCBI_TaxID=9823; Sus scrofa (Pig). RN [1] {ECO:0000313|EMBL:QIV64897.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Gre-172652224 {ECO:0000313|EMBL:QIV64897.1}; RX PubMed=32224109; RA Belbezier A., Deroux A., Sarrot-Reynauld F., Colombe B., Bosseray A., RA Wintenberger C., Dumanoir P., Lugosi M., Boccon-Gibod I., Leroy V., RA Maignan M., Collomb-Muret R., Viglino D., Vaillant M., Minotti L., RA Lagrange E., Epaulard O., Dumestre-Perard C., Lhomme S., Lupo J., RA Larrat S., Morand P., Schwebel C., Vilotitch A., Bosson J.L., Bouillet L.; RT "Screening of hepatitis E in patients presenting for acute neurological RT disorders."; RL J Infect Public Health 0:0-0(2020). CC -!- FUNCTION: Major viral capsid protein that encapsidates the viral CC genome. Binds to the 5' end of the genomic RNA. CC {ECO:0000256|RuleBase:RU363023}. CC -!- SUBUNIT: Self-assembles to form the capsid. CC {ECO:0000256|RuleBase:RU363023}. CC -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000256|ARBA:ARBA00004241}. CC Host cell surface {ECO:0000256|ARBA:ARBA00004426, CC ECO:0000256|RuleBase:RU363023}. Host cytoplasm CC {ECO:0000256|RuleBase:RU363023}. Virion {ECO:0000256|ARBA:ARBA00004328, CC ECO:0000256|RuleBase:RU363023}. CC -!- SIMILARITY: Belongs to the hepevirus capsid protein family. CC {ECO:0000256|ARBA:ARBA00008877, ECO:0000256|RuleBase:RU363023}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MN747092; QIV64897.1; -; Genomic_RNA. DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0044228; C:host cell surface; IEA:UniProtKB-SubCell. DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR Gene3D; 2.60.120.20; -; 1. DR InterPro; IPR004261; SP2. DR InterPro; IPR029053; Viral_coat. DR Pfam; PF03014; SP2; 1. PE 3: Inferred from homology; KW Capsid protein {ECO:0000256|RuleBase:RU363023}; KW Host cytoplasm {ECO:0000256|RuleBase:RU363023}; KW RNA-binding {ECO:0000256|RuleBase:RU363023}; KW Virion {ECO:0000256|RuleBase:RU363023}. FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:QIV64897.1" FT NON_TER 116 FT /evidence="ECO:0000313|EMBL:QIV64897.1" SQ SEQUENCE 116 AA; 12451 MW; 8368F67EFBD8C068 CRC64; XXXXIXXSPX NSYTNTPYTG ALGLLDFALE LEFRNLXPGN TNTRVSRYTS TARHRLRRGA DGTAELTTTA ATRFMKDLHF TGTNGVGEVG RGIALTLFNL ADTLLGGLPT ELISSA //