ID   A0A6G7ZAM0_9FIRM        Unreviewed;       433 AA.
AC   A0A6G7ZAM0;
DT   12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT   12-AUG-2020, sequence version 1.
DT   02-DEC-2020, entry version 3.
DE   RecName: Full=Signal recognition particle protein {ECO:0000256|HAMAP-Rule:MF_00306};
DE   AltName: Full=Fifty-four homolog {ECO:0000256|HAMAP-Rule:MF_00306};
GN   Name=ffh {ECO:0000256|HAMAP-Rule:MF_00306,
GN   ECO:0000313|EMBL:QIK86009.1};
GN   ORFNames=G7061_05075 {ECO:0000313|EMBL:QIK86009.1};
OS   Erysipelothrix sp. HDW6B.
OC   Bacteria; Firmicutes; Erysipelotrichia; Erysipelotrichales;
OC   Erysipelotrichaceae; Erysipelothrix; unclassified Erysipelothrix.
OX   NCBI_TaxID=2714929 {ECO:0000313|EMBL:QIK86009.1, ECO:0000313|Proteomes:UP000503239};
RN   [1] {ECO:0000313|EMBL:QIK86009.1, ECO:0000313|Proteomes:UP000503239}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HDW6B {ECO:0000313|EMBL:QIK86009.1,
RC   ECO:0000313|Proteomes:UP000503239};
RA   Hyun D.-W., Bae J.-W.;
RT   "Erysipelothrix sp. nov. isolated from aquatic animals.";
RL   Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in targeting and insertion of nascent membrane
CC       proteins into the cytoplasmic membrane. Binds to the hydrophobic signal
CC       sequence of the ribosome-nascent chain (RNC) as it emerges from the
CC       ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic
CC       membrane where it interacts with the SRP receptor FtsY.
CC       {ECO:0000256|HAMAP-Rule:MF_00306}.
CC   -!- SUBUNIT: Part of the signal recognition particle protein translocation
CC       system, which is composed of SRP and FtsY. {ECO:0000256|HAMAP-
CC       Rule:MF_00306}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00306}.
CC       Note=The SRP-RNC complex is targeted to the cytoplasmic membrane.
CC       {ECO:0000256|HAMAP-Rule:MF_00306}.
CC   -!- DOMAIN: Composed of three domains: the N-terminal N domain, which is
CC       responsible for interactions with the ribosome, the central G domain,
CC       which binds GTP, and the C-terminal M domain, which binds the RNA and
CC       the signal sequence of the RNC. {ECO:0000256|HAMAP-Rule:MF_00306}.
CC   -!- SIMILARITY: Belongs to the GTP-binding SRP family. SRP54 subfamily.
CC       {ECO:0000256|ARBA:ARBA00005450, ECO:0000256|HAMAP-Rule:MF_00306}.
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DR   EMBL; CP049860; QIK86009.1; -; Genomic_DNA.
DR   Proteomes; UP000503239; Chromosome.
DR   GO; GO:0048500; C:signal recognition particle; IEA:UniProtKB-UniRule.
DR   GO; GO:0008312; F:7S RNA binding; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR   Gene3D; 1.10.260.30; -; 1.
DR   Gene3D; 1.20.120.140; -; 1.
DR   HAMAP; MF_00306; SRP54; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036891; Signal_recog_part_SRP54_M_sf.
DR   InterPro; IPR013822; Signal_recog_particl_SRP54_hlx.
DR   InterPro; IPR004125; Signal_recog_particle_SRP54_M.
DR   InterPro; IPR004780; SRP.
DR   InterPro; IPR022941; SRP54.
DR   InterPro; IPR000897; SRP54_GTPase_dom.
DR   InterPro; IPR042101; SRP54_N_sf.
DR   PANTHER; PTHR11564; PTHR11564; 1.
DR   PANTHER; PTHR11564:SF7; PTHR11564:SF7; 1.
DR   Pfam; PF00448; SRP54; 1.
DR   Pfam; PF02881; SRP54_N; 1.
DR   Pfam; PF02978; SRP_SPB; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00962; SRP54; 1.
DR   SMART; SM00963; SRP54_N; 1.
DR   SUPFAM; SSF47446; SSF47446; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00959; ffh; 1.
DR   PROSITE; PS00300; SRP54; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00306};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|HAMAP-
KW   Rule:MF_00306};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_00306};
KW   Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274, ECO:0000256|HAMAP-
KW   Rule:MF_00306};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW   Rule:MF_00306};
KW   Signal recognition particle {ECO:0000256|ARBA:ARBA00023135,
KW   ECO:0000256|HAMAP-Rule:MF_00306}.
FT   DOMAIN          266..279
FT                   /note="SRP54"
FT                   /evidence="ECO:0000259|PROSITE:PS00300"
FT   NP_BIND         107..114
FT                   /note="GTP"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00306"
FT   NP_BIND         187..191
FT                   /note="GTP"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00306"
FT   NP_BIND         245..248
FT                   /note="GTP"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00306"
SQ   SEQUENCE   433 AA;  47844 MW;  88B50029C33DD30B CRC64;
     MAFDNLTNRL QDTFKNLTGK GKLTEKNIAD ALSEIRISLL EADVSLEVIN ELLDYTRKEA
     MGMKVVRDVD PSQMFIKIVN DKLVEILGEE HQGLTFTRKP GVMMMVGLQG SGKTTSIAKI
     ARELKVKEDK KVLLVAADLA RPAAIEQLKI LGERIGVEVF AKENSTPVEV VTDALSYGKD
     FDVILIDTAG RLQIDEALMQ QLVDIQALAK PEEILLSVDA MSGQDVIHVA NGFKSKLNLT
     GLVATKFDGD SRGGSILSVR YMTKVPVKYV GVGEGIEELE AFHPDRTASR ILGMGDIVSL
     VEKAQEKMDI EASEKSAERM MNGQFTLDDM LIQLQQVSKM GPISGLLKML PGANQMANQI
     DDDDASKGMK KTEAMIQSMT KEERNDPTII RSGRKHRIAK GSGVTTTDVN RLLSQYDKMK
     KQMRMFSRMM GKQ
//