ID A0A6G0UUT3_9BILA Unreviewed; 904 AA. AC A0A6G0UUT3; DT 12-AUG-2020, integrated into UniProtKB/TrEMBL. DT 12-AUG-2020, sequence version 1. DT 10-FEB-2021, entry version 4. DE RecName: Full=DNA replication licensing factor MCM2 {ECO:0000256|ARBA:ARBA00018925}; DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551}; GN ORFNames=FO519_003957 {ECO:0000313|EMBL:KAE9552844.1}; OS Halicephalobus sp. NKZ332. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Tylenchina; Panagrolaimomorpha; Panagrolaimoidea; Panagrolaimidae; OC Halicephalobus; unclassified Halicephalobus. OX NCBI_TaxID=2598192 {ECO:0000313|EMBL:KAE9552844.1, ECO:0000313|Proteomes:UP000488831}; RN [1] {ECO:0000313|EMBL:KAE9552844.1, ECO:0000313|Proteomes:UP000488831} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NKZ332 {ECO:0000313|EMBL:KAE9552844.1}; RC TISSUE=Whole-body {ECO:0000313|EMBL:KAE9552844.1}; RX PubMed=31814372; RA Ragsdale E.J., Koutsovoulos G., Biddle J.F.; RT "A draft genome for a species of Halicephalobus (Panagrolaimidae)."; RL J. Nematol. 51:1-4(2019). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; CC Evidence={ECO:0000256|ARBA:ARBA00001665}; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|ARBA:ARBA00008010, CC ECO:0000256|RuleBase:RU004070}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:KAE9552844.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; VOSG01000113; KAE9552844.1; -; Genomic_DNA. DR Proteomes; UP000488831; Unassembled WGS sequence. DR GO; GO:0042555; C:MCM complex; IEA:InterPro. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro. DR GO; GO:1905775; P:negative regulation of DNA helicase activity; IEA:InterPro. DR InterPro; IPR031327; MCM. DR InterPro; IPR008045; MCM2. DR InterPro; IPR018525; MCM_CS. DR InterPro; IPR001208; MCM_dom. DR InterPro; IPR041562; MCM_lid. DR InterPro; IPR027925; MCM_N. DR InterPro; IPR033762; MCM_OB. DR InterPro; IPR012340; NA-bd_OB-fold. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR11630; PTHR11630; 1. DR Pfam; PF00493; MCM; 1. DR Pfam; PF12619; MCM2_N; 1. DR Pfam; PF17855; MCM_lid; 1. DR Pfam; PF14551; MCM_N; 1. DR Pfam; PF17207; MCM_OB; 1. DR PRINTS; PR01657; MCMFAMILY. DR PRINTS; PR01658; MCMPROTEIN2. DR SMART; SM00350; MCM; 1. DR SUPFAM; SSF50249; SSF50249; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS00847; MCM_1; 1. DR PROSITE; PS50051; MCM_2; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070}; KW DNA replication {ECO:0000256|ARBA:ARBA00022705}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070}; KW Helicase {ECO:0000256|ARBA:ARBA00022806}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, KW ECO:0000256|RuleBase:RU004070}; Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Reference proteome {ECO:0000313|Proteomes:UP000488831}. FT DOMAIN 473..679 FT /note="MCM" FT /evidence="ECO:0000259|PROSITE:PS50051" FT REGION 1..101 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 39..53 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 54..74 FT /note="Acidic" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 904 AA; 102475 MW; 0AD8DEB6F773B835 CRC64; MSQGSRGGRR TRRIFADDDD QSQFQSQASS VANPRDVDAL LGDDGHADDV VNELFGDERD EMDPEEEDGE DLFGDNMEAD YRPQPELDIL SQSGIDDDDV SEMSYSDRRA AELEMEERDR QLTGHEDRLF YEEGDVSQSQ TDSTRRARER MRRIRIVEDE DQMEEDIPID ILENLRGRTV RDHVNDKAIA REIIRRFKHF LRHFKGKGND QLKYVQRIQQ MASENKESLV VDYDDLADDE GQPSLSMFLP EAPLEVLELF DMATTDVVTS MYPHYKRICA NINTRVAGLP TYEDIRMLRH IHLNMLITTS GVVTVTSGIL PRLALVKYNC VACGYVIGPI TQGSEDEVKP SSCASCQSRG PFELNVEETV YQNYQRITIQ ESPNLVEAGR LPRSKDIILT GDLCDSCKPG DEIEVTGTYT NNYDSSLNSR QGFPVFAAVV IANYIRTKDQ IESDALTDED VAQIRKLSKD PDIAQRVFAS IAPTIYGHHD VKQAIALALF RGEQKNPNQK HALRGDINIL LCGDPGTAKS QFLRYVVHMA PRAVLTTGQG ASAVGLTAYV QRHPVTREWT LEAGAMVLAD KGVCLIDEFD KMTDQDRTSI HEAMEQQSIS ISKAGIVTSL RARCTVIAAA NPIGGRYDSS RTFAENVDLT EPILSRFDVL CVIRDQVDPI EDEHLAKFVI GNHIRMHPSR KNENQGSEES QIETESEYKL IPQNLLRKYI IFARNNIHPK LEEKAMDRLN GVYADLRKEA QSTGSVAITV RHIESMIRMS EAHAKLHLRS YVNDDDVNAA IRIMLESFIQ TQKASVMRQM RKHFIRQLTY KKDSNELLLY ILKQLIRDQL AYEQSRSHGD SASIEAITIS ETDLKTKARQ YNIDNLVPFY RSRLFTSNNF THDPSKKVIT QSLY //