ID A0A6E8VCB1_9DIPT Unreviewed; 514 AA. AC A0A6E8VCB1; DT 12-AUG-2020, integrated into UniProtKB/TrEMBL. DT 12-AUG-2020, sequence version 1. DT 02-JUN-2021, entry version 6. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:ACON002875-PA}; OS Anopheles coluzzii. OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; OC Anophelinae; Anopheles. OX NCBI_TaxID=1518534 {ECO:0000313|EnsemblMetazoa:ACON002875-PA, ECO:0000313|Proteomes:UP000075882}; RN [1] {ECO:0000313|Proteomes:UP000075882} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Mali-NIH {ECO:0000313|Proteomes:UP000075882}; RX PubMed=30669388; DOI=10.3390/genes10010062; RA Kingan S.B., Heaton H., Cudini J., Lambert C.C., Baybayan P., Galvin B.D., RA Durbin R., Korlach J., Lawniczak M.K.N.; RT "A High-Quality De novo Genome Assembly from a Single Mosquito Using PacBio RT Sequencing."; RL Genes (Basel) 10:0-E62(2019). RN [2] {ECO:0000313|EnsemblMetazoa:ACON002875-PA} RP IDENTIFICATION. RC STRAIN=Ngousso {ECO:0000313|EnsemblMetazoa:ACON002875-PA}; RG EnsemblMetazoa; RL Submitted (MAY-2020) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC -!- SIMILARITY: Belongs to the HEXIM family. CC {ECO:0000256|ARBA:ARBA00008409}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EnsemblMetazoa; ACON002875-RA; ACON002875-PA; ACON002875. DR Proteomes; UP000075882; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IEA:InterPro. DR GO; GO:0017069; F:snRNA binding; IEA:InterPro. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:InterPro. DR InterPro; IPR024872; HEXIM. DR PANTHER; PTHR13469; PTHR13469; 1. DR Pfam; PF15313; HEXIM; 1. DR PRINTS; PR02094; HEXIMFAMILY. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Transcription {ECO:0000256|ARBA:ARBA00023163}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}. FT REGION 1..44 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 58..186 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 284..327 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 387..444 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 457..514 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 328..355 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 22..44 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 73..87 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 111..131 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 136..150 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 388..423 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 481..495 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 514 AA; 54654 MW; 27121DD9B0FDDF34 CRC64; MSIENSMETA ESMAFTRQCD EVDALPSQTA QSSGSCEPNV VGSSSNAATV GAMVAPAATA NDGGASVAAG EDGGRRPLDD DGRRSGGLVS RQDSNEQSEA NRDGKGHPGV GSNQGNGTGV PMATAATMSN RTGEGRCRRK NRRRKSNRGK SSSNRPYSKT QWKFLCPPGG QPGGGGGGGR PENNCNKRRH LYSVAASRRI TPFLKSDQPP LVPYNTNRFL MEDHMPQVLT PSEDEEDFLT KEFSSVYERE RFERLESLSH PDLVQEYIKL AIEYEQLVRR NGVTGEGGVG GGRGGGGGGG GDCEGGNMAK VAGSDGERGD DGSGAARSRL LEERVKVLER ENIDLRRQLE HATRMGFLLS ARSSPRYGVP TANAASLDRM DVAEQQQRLP ALDSSTSEDS ESDSSSTSSS SSSSSSSSSS ASSMSDDDDR DDRDEPMVMD PMAEVDRAYG VRMMNGLAPL SPLMNGGSPR ANGLAHDSSD QEQDGEDEDD EQQQLLLNGV DELSPSPRPS LAVE //