ID A0A6C1E0Q7_SACPS Unreviewed; 103 AA. AC A0A6C1E0Q7; DT 17-JUN-2020, integrated into UniProtKB/TrEMBL. DT 17-JUN-2020, sequence version 1. DT 02-DEC-2020, entry version 4. DE RecName: Full=Histone H4 {ECO:0000256|RuleBase:RU000528}; GN Name=HHF1_2 {ECO:0000313|EMBL:QID82104.1}; GN Synonyms=HHF1_1 {ECO:0000313|EMBL:QID78017.1}, HHF1_3 GN {ECO:0000313|EMBL:QID83339.1}, HHF1_4 {ECO:0000313|EMBL:QID87755.1}; GN ORFNames=GRS66_000214 {ECO:0000313|EMBL:QID78017.1}, GRS66_004511 GN {ECO:0000313|EMBL:QID82104.1}, GRS66_005795 GN {ECO:0000313|EMBL:QID83339.1}, GRS66_010441 GN {ECO:0000313|EMBL:QID87755.1}; OS Saccharomyces pastorianus (Lager yeast) (Saccharomyces cerevisiae x OS Saccharomyces eubayanus). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=27292 {ECO:0000313|EMBL:QID82104.1, ECO:0000313|Proteomes:UP000501346}; RN [1] {ECO:0000313|EMBL:QID82104.1, ECO:0000313|Proteomes:UP000501346} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CBS 1483 {ECO:0000313|EMBL:QID82104.1, RC ECO:0000313|Proteomes:UP000501346}; RX PubMed=31791228; RA Salazar A.N., Gorter de Vries A.R., van den Broek M., Brouwers N., RA de la Torre Cortes P., Kuijpers N.G.A., Daran J.G., Abeel T.; RT "Chromosome level assembly and comparative genome analysis confirm lager- RT brewing yeasts originated from a single hybridization."; RL BMC Genomics 20:0-916(2019). RN [2] {ECO:0000313|EMBL:QID82104.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CBS 1483 {ECO:0000313|EMBL:QID82104.1}; RA Daran J.-M.G., van den Broek M.; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact CC DNA into chromatin, limiting DNA accessibility to the cellular CC machineries which require DNA as a template. Histones thereby play a CC central role in transcription regulation, DNA repair, DNA replication CC and chromosomal stability. DNA accessibility is regulated via a complex CC set of post-translational modifications of histones, also called CC histone code, and nucleosome remodeling. CC {ECO:0000256|RuleBase:RU000528}. CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of CC DNA. {ECO:0000256|RuleBase:RU000528}. CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}. CC Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC -!- SIMILARITY: Belongs to the histone H4 family. CC {ECO:0000256|ARBA:ARBA00006564, ECO:0000256|RuleBase:RU000528}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP048984; QID78017.1; -; Genomic_DNA. DR EMBL; CP048995; QID82104.1; -; Genomic_DNA. DR EMBL; CP048999; QID83339.1; -; Genomic_DNA. DR EMBL; CP049011; QID87755.1; -; Genomic_DNA. DR Proteomes; UP000501346; Chromosome scxiv. DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro. DR CDD; cd00076; H4; 1. DR Gene3D; 1.10.20.10; -; 1. DR InterPro; IPR035425; CENP-T/H4_C. DR InterPro; IPR009072; Histone-fold. DR InterPro; IPR001951; Histone_H4. DR InterPro; IPR019809; Histone_H4_CS. DR Pfam; PF15511; CENP-T_C; 1. DR PRINTS; PR00623; HISTONEH4. DR SMART; SM00417; H4; 1. DR SUPFAM; SSF47113; SSF47113; 1. DR PROSITE; PS00047; HISTONE_H4; 1. PE 3: Inferred from homology; KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU000528}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000528}; KW Nucleosome core {ECO:0000256|ARBA:ARBA00023269, KW ECO:0000256|RuleBase:RU000528}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU000528}. FT DOMAIN 34..96 FT /note="CENP-T_C" FT /evidence="ECO:0000259|Pfam:PF15511" FT REGION 1..20 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 103 AA; 11368 MW; 69B7D1F89E62DE41 CRC64; MSGRGKGGKG LGKGGAKRHR KILRDNIQGI TKPAIRRLAR RGGVKRISGL IYEEVRAVLK SFLESVIRDS VTYTEHAKRK TVTSLDVVYA LKRQGRTLYG FGG //