ID A0A6B9BBG9_MYCAV Unreviewed; 496 AA. AC A0A6B9BBG9; DT 17-JUN-2020, integrated into UniProtKB/TrEMBL. DT 17-JUN-2020, sequence version 1. DT 28-JUN-2023, entry version 8. DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438}; DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438}; GN Name=tcrY_1 {ECO:0000313|EMBL:QGW30479.1}; GN ORFNames=MAA44156_00212 {ECO:0000313|EMBL:QGW30479.1}; OS Mycobacterium avium subsp. avium. OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae; OC Mycobacterium; Mycobacterium avium complex (MAC). OX NCBI_TaxID=44454 {ECO:0000313|EMBL:QGW30479.1, ECO:0000313|Proteomes:UP000425302}; RN [1] {ECO:0000313|EMBL:QGW30479.1, ECO:0000313|Proteomes:UP000425302} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DSM 44156 {ECO:0000313|EMBL:QGW30479.1, RC ECO:0000313|Proteomes:UP000425302}; RA Goethe R., Laarmann K., Sproer C., Bunk B.; RT "Complete genome sequence of Mycobacterium avium subsp. avium Chester DSM RT 44156."; RL Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L- CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP046507; QGW30479.1; -; Genomic_DNA. DR AlphaFoldDB; A0A6B9BBG9; -. DR Proteomes; UP000425302; Chromosome. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro. DR CDD; cd06225; HAMP; 1. DR CDD; cd00075; HATPase; 1. DR CDD; cd00082; HisKA; 1. DR Gene3D; 1.10.287.130; -; 1. DR Gene3D; 6.10.340.10; -; 1. DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1. DR InterPro; IPR003660; HAMP_dom. DR InterPro; IPR003594; HATPase_C. DR InterPro; IPR036890; HATPase_C_sf. DR InterPro; IPR005467; His_kinase_dom. DR InterPro; IPR003661; HisK_dim/P. DR InterPro; IPR036097; HisK_dim/P_sf. DR InterPro; IPR004358; Sig_transdc_His_kin-like_C. DR PANTHER; PTHR45436:SF5; SENSOR HISTIDINE KINASE TRCS; 1. DR PANTHER; PTHR45436; SENSOR HISTIDINE KINASE YKOH; 1. DR Pfam; PF00672; HAMP; 1. DR Pfam; PF02518; HATPase_c; 1. DR Pfam; PF00512; HisKA; 1. DR PRINTS; PR00344; BCTRLSENSOR. DR SMART; SM00304; HAMP; 1. DR SMART; SM00387; HATPase_c; 1. DR SMART; SM00388; HisKA; 1. DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1. DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1. DR PROSITE; PS50885; HAMP; 1. DR PROSITE; PS50109; HIS_KIN; 1. PE 4: Predicted; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:QGW30479.1}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:QGW30479.1}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 12..32 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 172..198 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 199..261 FT /note="HAMP" FT /evidence="ECO:0000259|PROSITE:PS50885" FT DOMAIN 276..489 FT /note="Histidine kinase" FT /evidence="ECO:0000259|PROSITE:PS50109" FT REGION 58..84 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 496 AA; 52880 MW; B6917EA0AB70323E CRC64; MADTRRVWSL RLRLLVGQIV VLALVCLGIT AVTELALNHH LVKQLDGQLA GTSFRSALMY PEPNHPRHEH SPYPRPGPGP RFLDAPGQPA GMVAAVVGHG KTVDAGYLTS SGTRDALTST AQTQLEQIAG SRAPVTVNLD GLGRYRVVAA PSRNGSDIIV TGLSMANIDA TLIRMLVIFG IVTVIALAAA TIAGVVIIRR ALAPLRRVAQ TAREVADLPL ARGEVELPVR VRESDANPST EVGQLGAALN RMLDHIADAL SARQASETRV RQFVADASHE LRTPLAAIRG YTELTQRMGD DREAVAQAMS RVASETERMT RLVEDLLLLA RLDSGRPLER EPVDLSRLAV DAVNDAHVAG PDHQWELDLP EEPVVVTGDA ARLHQVLTNL LANARVHTGA GTVVTTRLST EPAHTVLQVI DNGPGIPAEL QSEVFERFAR GDSSRSRKGG STGLGLAIVS AVVKAHNGTI SVNSSPGHTE FTVRLPPNGW QPHASA //