ID   A0A678ZHJ0_HUMAN        Unreviewed;       183 AA.
AC   A0A678ZHJ0;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   12-AUG-2020, entry version 2.
DE   SubName: Full=MHC class II antigen {ECO:0000313|EMBL:AZU88177.1};
DE   Flags: Fragment;
GN   Name=HLA-DRB1 {ECO:0000313|EMBL:AZU88177.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AZU88177.1};
RN   [1] {ECO:0000313|EMBL:AZU88177.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Cereb N., Yang S.Y.;
RT   "HLA new alleles found by Histogenetics.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004530}. Lysosome membrane
CC       {ECO:0000256|ARBA:ARBA00004352}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004352}.
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DR   EMBL; MK225473; AZU88177.1; -; Genomic_DNA.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.10.320.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR000353; MHC_II_b_N.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00969; MHC_II_beta; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00921; MHC_II_beta; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF54452; SSF54452; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   4: Predicted;
KW   Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   MHC II {ECO:0000256|ARBA:ARBA00023182};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          92..180
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AZU88177.1"
FT   NON_TER         183
FT                   /evidence="ECO:0000313|EMBL:AZU88177.1"
SQ   SEQUENCE   183 AA;  21329 MW;  4DF0AB9158947245 CRC64;
     RFLEYSTSEC HFFNGTERVR YLDRYFHNQE ENVRFDSDVG EFRAVTELGR PDAEYWNSQK
     DILEDERAAV DTYCRHNYGV VESFTVQRRV HPKVTVYPSK TQPLQHHNLL VCSVSGFYPG
     SIEVRWFRNG QEEKTGVVST GLIHNGDWTF QTLVMLETVP RSGEVYTCQV EHPSVTSPLT
     VEW
//