ID A0A674JW73_TERCA Unreviewed; 386 AA. AC A0A674JW73; DT 17-JUN-2020, integrated into UniProtKB/TrEMBL. DT 17-JUN-2020, sequence version 1. DT 28-JUN-2023, entry version 12. DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180}; DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180}; OS Terrapene carolina triunguis (Three-toed box turtle). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira; OC Testudinoidea; Emydidae; Terrapene. OX NCBI_TaxID=2587831 {ECO:0000313|Ensembl:ENSTMTP00000025645.1, ECO:0000313|Proteomes:UP000472274}; RN [1] {ECO:0000313|Ensembl:ENSTMTP00000025645.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2023) to UniProtKB. CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family. CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A674JW73; -. DR Ensembl; ENSTMTT00000026565.1; ENSTMTP00000025645.1; ENSTMTG00000018719.1. DR GeneTree; ENSGT00940000163417; -. DR InParanoid; A0A674JW73; -. DR Proteomes; UP000472274; Unplaced. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro. DR GO; GO:0006508; P:proteolysis; IEA:InterPro. DR Gene3D; 3.30.70.270; -; 1. DR Gene3D; 2.40.70.10; Acid Proteases; 1. DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1. DR InterPro; IPR043502; DNA/RNA_pol_sf. DR InterPro; IPR001995; Peptidase_A2_cat. DR InterPro; IPR021109; Peptidase_aspartic_dom_sf. DR InterPro; IPR018061; Retropepsins. DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase. DR InterPro; IPR000477; RT_dom. DR PANTHER; PTHR33064; POL PROTEIN; 1. DR PANTHER; PTHR33064:SF31; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1. DR Pfam; PF00077; RVP; 1. DR Pfam; PF00078; RVT_1; 1. DR SUPFAM; SSF50630; Acid proteases; 1. DR SUPFAM; SSF56672; DNA/RNA polymerases; 1. DR PROSITE; PS50175; ASP_PROT_RETROV; 1. DR PROSITE; PS50878; RT_POL; 1. PE 3: Inferred from homology; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000472274}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}; KW Transposable element {ECO:0000256|ARBA:ARBA00022464}. FT TRANSMEM 321..344 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 8..79 FT /note="Peptidase A2" FT /evidence="ECO:0000259|PROSITE:PS50175" FT DOMAIN 180..379 FT /note="Reverse transcriptase" FT /evidence="ECO:0000259|PROSITE:PS50878" SQ SEQUENCE 386 AA; 43083 MW; CB345F9A65627708 CRC64; MRVGDSDIDF LIDSGAARTA VNQPLQLPVA DSLTVVGATG KGTKCPVYAP AECALGNRTL SHKLVYLPDC PTPLLGRDLL CRLGATLHFT QDEITLTLPP ENAWIMTLAT EPSAMQAPEW SQWEKQVFPL VWASGVPGKA NRQTPVHIQL LPGKSPVRIK QYPIKREARE GLQETIDRFL ECGVLRECQS AWNTPILPVR KPNGTYRLVQ DLRAVNERVK TLHPLVPNPY TLLASIGGQY THFSVLDLKD AFFTIPVDTQ SQEIFSFEWE DNRRVKKQLC WTVLAQGFKN SPTLFGQALT RDLEEWDNED RVLLLQYVDD LLIAAVGLIP CLKATVSLLN FVGLRGYRVA QSKSLDCGLN PCMNALRERI MTPFTGPQKR TGHLKS //