ID   A0A672K255_SINGR        Unreviewed;       567 AA.
AC   A0A672K255;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   07-APR-2021, entry version 6.
DE   RecName: Full=Protein tweety homolog {ECO:0000256|RuleBase:RU361114};
GN   Name=LOC107564174 {ECO:0000313|Ensembl:ENSSGRP00000004295};
OS   Sinocyclocheilus grahami (Dianchi golden-line fish) (Barbus grahami).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Sinocyclocheilus.
OX   NCBI_TaxID=75366 {ECO:0000313|Ensembl:ENSSGRP00000004295, ECO:0000313|Proteomes:UP000472262};
RN   [1] {ECO:0000313|Ensembl:ENSSGRP00000004295}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2020) to UniProtKB.
CC   -!- FUNCTION: Probable chloride channel. {ECO:0000256|RuleBase:RU361114}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the tweety family.
CC       {ECO:0000256|ARBA:ARBA00009849, ECO:0000256|RuleBase:RU361114}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU361114}.
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DR   Ensembl; ENSSGRT00000004661; ENSSGRP00000004295; ENSSGRG00000002354.
DR   GeneTree; ENSGT00950000183060; -.
DR   Proteomes; UP000472262; Unplaced.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-UniRule.
DR   CDD; cd07912; Tweety_N; 1.
DR   InterPro; IPR006990; Tweety.
DR   PANTHER; PTHR12424; PTHR12424; 1.
DR   Pfam; PF04906; Tweety; 1.
PE   3: Inferred from homology;
KW   Chloride {ECO:0000256|RuleBase:RU361114};
KW   Chloride channel {ECO:0000256|RuleBase:RU361114};
KW   Ion channel {ECO:0000256|RuleBase:RU361114};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361114};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361114};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361114};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361114};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361114}.
FT   TRANSMEM        44..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        86..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        210..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        238..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        263..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        396..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   REGION          423..445
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          493..567
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        493..559
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   567 AA;  63506 MW;  8241D8BBAC0666A2 CRC64;
     MAAVVNYSPP WWVNLFHRLP HFNLQFQLTS SDFRPEDSEY QKSVLLLGAV ALVCLALDLL
     FLLFYSFWLC CRRRKNHDSP NADCCCTAWC VIIATLVCSA GIAVGFYGNG ETCDGMTRLT
     YSLRHANQTV AGIDKLVKST SSLNETLQEG LVQLETVYSK HTDYLSIVQK LQGQLDELIN
     LMVEVPFWSS TDISLDHLAS LTEQYDWYRW LGYLGLLLFD VIICLLILVG LIRNSRSILI
     SVCLLGVLTL VISWASLGLE FSVAVVSILA KTPLILFNFM PIYFCLVLWL SKKTRDKLYI
     MQYYLRCSMG QTNPFQQKLS GSHKALVEMQ DDVSELLRSA IREFPKTKSN LEEMQAVLNS
     TEISLHHLTA LVDCRGLHMD YVQALTGLCY DGVEGLIYLV LFSFITALMF SSIVCSVPHT
     WQSKRSEEED GDETSATLGP RAPHDNLYRV HMPSLYSCGS STYGSEASLP AAAHTVSNAP
     VTEYMSQNAN FQTPRCENTP LIGRESPPPS YTSSMRAKYL ATSRPDQSRP SESQNGLVPN
     MRPDLTSRSA PNSRPNSAIH RPHSAIH
//