ID A0A671N1C5_9TELE Unreviewed; 226 AA. AC A0A671N1C5; DT 17-JUN-2020, integrated into UniProtKB/TrEMBL. DT 17-JUN-2020, sequence version 1. DT 28-JUN-2023, entry version 13. DE RecName: Full=Insulin-induced gene protein {ECO:0000256|RuleBase:RU241113}; GN Name=LOC107689500 {ECO:0000313|Ensembl:ENSSANP00000038157.1}; OS Sinocyclocheilus anshuiensis. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Cyprininae; Sinocyclocheilus. OX NCBI_TaxID=1608454 {ECO:0000313|Ensembl:ENSSANP00000038157.1, ECO:0000313|Proteomes:UP000472260}; RN [1] {ECO:0000313|Ensembl:ENSSANP00000038157.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2023) to UniProtKB. CC -!- FUNCTION: Mediates feedback control of cholesterol synthesis. CC {ECO:0000256|RuleBase:RU241113}. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU241113}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477, CC ECO:0000256|RuleBase:RU241113}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the INSIG family. CC {ECO:0000256|ARBA:ARBA00007475, ECO:0000256|RuleBase:RU241113}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_016342988.1; XM_016487502.1. DR RefSeq; XP_016342989.1; XM_016487503.1. DR AlphaFoldDB; A0A671N1C5; -. DR Ensembl; ENSSANT00000040605.1; ENSSANP00000038157.1; ENSSANG00000019413.1. DR GeneID; 107689500; -. DR KEGG; sanh:107689500; -. DR OrthoDB; 2943928at2759; -. DR Proteomes; UP000472260; Unplaced. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW. DR InterPro; IPR025929; INSIG_fam. DR PANTHER; PTHR15301; INSULIN-INDUCED GENE 1; 1. DR PANTHER; PTHR15301:SF10; INSULIN-INDUCED GENE 2 PROTEIN; 1. DR Pfam; PF07281; INSIG; 1. PE 3: Inferred from homology; KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548, KW ECO:0000256|RuleBase:RU241113}; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824, KW ECO:0000256|RuleBase:RU241113}; KW Lipid metabolism {ECO:0000256|RuleBase:RU241113}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU241113}; KW Reference proteome {ECO:0000313|Proteomes:UP000472260}; KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221, KW ECO:0000256|RuleBase:RU241113}; KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU241113}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 29..50 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 70..89 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 132..149 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 156..175 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 187..207 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" SQ SEQUENCE 226 AA; 25009 MW; 158CCC9DE30E85BE CRC64; MAEVSALSSG ALMRRGPYIS MITNRTMNVL IRAAVLFMVG VFLALVLNLL QVQRNVTLFP PDVISSIFSS AWWVPPCCGT AAALIGLLYP CMDRRLGEPH KLKREWSNVM RCVAVFVGIN HASAKVDFAN NVQLSLTLAA LSVGLWWTFD RSRSGFGLGV VIAILATLAT QLLVYNGVFQ YTSPDFLYIR SWLPCIFFAG VITVGNIGRQ LALYEYKVSQ EKTHQD //