ID A0A667G1E1_LYNCA Unreviewed; 398 AA. AC A0A667G1E1; DT 17-JUN-2020, integrated into UniProtKB/TrEMBL. DT 17-JUN-2020, sequence version 1. DT 12-AUG-2020, entry version 2. DE RecName: Full=Tyrosinase_Cu-bd domain-containing protein {ECO:0000259|PROSITE:PS00497}; GN Name=DCT {ECO:0000313|Ensembl:ENSLCNP00005000447}; OS Lynx canadensis (Canada lynx). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Lynx. OX NCBI_TaxID=61383 {ECO:0000313|Ensembl:ENSLCNP00005000447}; RN [1] {ECO:0000313|Ensembl:ENSLCNP00005000447} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lama T., Johnson W., Organ J.F., Vashon J., Fedrigo O., Mountcastle J., RA Haase B., Rhie A., Koren S., Phillippy A., Collins J., Chow W., Howe K., RA Lewin H., Durbin R., Myers G., O'Brien S., Koepfli K.-P., Ryder O., RA Damas J., Formenti G., Jarvis E.D.; RT "G10K-VGP Canada lynx genome, primary haplotype."; RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLCNP00005000447} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2020) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Melanosome membrane CC {ECO:0000256|ARBA:ARBA00004573}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004573}. CC -!- SIMILARITY: Belongs to the tyrosinase family. CC {ECO:0000256|ARBA:ARBA00009928}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSLCNT00005000529; ENSLCNP00005000447; ENSLCNG00005000312. DR Proteomes; UP000472241; Mitochondrion. DR Gene3D; 1.10.1280.10; -; 1. DR InterPro; IPR002227; Tyrosinase_Cu-bd. DR InterPro; IPR008922; Unchr_di-copper_centre. DR Pfam; PF00264; Tyrosinase; 1. DR PRINTS; PR00092; TYROSINASE. DR SUPFAM; SSF48056; SSF48056; 1. DR PROSITE; PS00497; TYROSINASE_1; 1. PE 3: Inferred from homology; KW Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..23 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 24..398 FT /note="Tyrosinase_Cu-bd domain-containing protein" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5025361017" FT DOMAIN 211..228 FT /note="Tyrosinase_Cu-bd" FT /evidence="ECO:0000259|PROSITE:PS00497" SQ SEQUENCE 398 AA; 45510 MW; EB01243214B33D0B CRC64; MSPLGWGLLL GCLGCGILPG AWAQFPRVCM TVNNLVSKEC CPPLGEDPDN ICGYLEGRGQ CVEVQADTRP WSGPYILRNQ DDREWWPRKF FHRTCRCRGH FYGYHCGFCR FGWTGHDCNE RKPLVVRKNI HSLTLQEREQ FLDALDLAKN TTHPDYVITT QHWLGLLGPN GTQPQIANSS IYDFFVWLHY YSVRDTLLGP GRPYKAIDFS HQGPAFVTWH RYHLLWLERD LQRLIGNESF ALPYWNFATG KNECDVCTDQ LFGAARQDDP TLISQNSRFS SWEVICDSLD DYNRRVTLCN GTSEGLLRRN QVGRNSEKLP TLKDVQDCLS LKKFDNPPFF QNSTFSFRNA LEGFDKANGI LDSQMMSLHN LVHSFLNGTS ALPHSAANDP IFVHSAYK //