ID A0A667G1E1_LYNCA Unreviewed; 398 AA. AC A0A667G1E1; DT 17-JUN-2020, integrated into UniProtKB/TrEMBL. DT 17-JUN-2020, sequence version 1. DT 29-MAY-2024, entry version 18. DE RecName: Full=L-dopachrome tautomerase {ECO:0000256|ARBA:ARBA00039823}; DE EC=5.3.3.12 {ECO:0000256|ARBA:ARBA00038932}; DE AltName: Full=L-dopachrome Delta-isomerase {ECO:0000256|ARBA:ARBA00042019}; DE AltName: Full=Tyrosinase-related protein 2 {ECO:0000256|ARBA:ARBA00041443}; GN Name=DCT {ECO:0000313|Ensembl:ENSLCNP00005000447.1}; OS Lynx canadensis (Canada lynx) (Felis canadensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Lynx. OX NCBI_TaxID=61383 {ECO:0000313|Ensembl:ENSLCNP00005000447.1, ECO:0000313|Proteomes:UP000472241}; RN [1] {ECO:0000313|Ensembl:ENSLCNP00005000447.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2023) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=L-dopachrome = 5,6-dihydroxyindole-2-carboxylate; CC Xref=Rhea:RHEA:13041, ChEBI:CHEBI:16875, ChEBI:CHEBI:57509; CC EC=5.3.3.12; Evidence={ECO:0000256|ARBA:ARBA00036823}; CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Evidence={ECO:0000256|ARBA:ARBA00001947}; CC -!- PATHWAY: Pigment biosynthesis; melanin biosynthesis. CC {ECO:0000256|ARBA:ARBA00037907}. CC -!- SUBCELLULAR LOCATION: Melanosome membrane CC {ECO:0000256|ARBA:ARBA00004573}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004573}. Membrane CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004479}. CC -!- SIMILARITY: Belongs to the tyrosinase family. CC {ECO:0000256|ARBA:ARBA00009928}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A667G1E1; -. DR Ensembl; ENSLCNT00005000529.1; ENSLCNP00005000447.1; ENSLCNG00005000312.1. DR Proteomes; UP000472241; Unplaced. DR GO; GO:0033162; C:melanosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004167; F:dopachrome isomerase activity; IEA:TreeGrafter. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro. DR GO; GO:0048066; P:developmental pigmentation; IEA:TreeGrafter. DR GO; GO:0006583; P:melanin biosynthetic process from tyrosine; IEA:TreeGrafter. DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:TreeGrafter. DR GO; GO:0021847; P:ventricular zone neuroblast division; IEA:TreeGrafter. DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1. DR InterPro; IPR008922; Di-copper_centre_dom_sf. DR InterPro; IPR002227; Tyrosinase_Cu-bd. DR PANTHER; PTHR11474:SF4; L-DOPACHROME TAUTOMERASE; 1. DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1. DR Pfam; PF00264; Tyrosinase; 1. DR PRINTS; PR00092; TYROSINASE. DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1. DR PROSITE; PS00497; TYROSINASE_1; 1. PE 3: Inferred from homology; KW Isomerase {ECO:0000256|ARBA:ARBA00023235}; KW Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Reference proteome {ECO:0000313|Proteomes:UP000472241}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..23 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 24..398 FT /note="L-dopachrome tautomerase" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5025361017" FT DOMAIN 211..228 FT /note="Tyrosinase copper-binding" FT /evidence="ECO:0000259|PROSITE:PS00497" SQ SEQUENCE 398 AA; 45510 MW; EB01243214B33D0B CRC64; MSPLGWGLLL GCLGCGILPG AWAQFPRVCM TVNNLVSKEC CPPLGEDPDN ICGYLEGRGQ CVEVQADTRP WSGPYILRNQ DDREWWPRKF FHRTCRCRGH FYGYHCGFCR FGWTGHDCNE RKPLVVRKNI HSLTLQEREQ FLDALDLAKN TTHPDYVITT QHWLGLLGPN GTQPQIANSS IYDFFVWLHY YSVRDTLLGP GRPYKAIDFS HQGPAFVTWH RYHLLWLERD LQRLIGNESF ALPYWNFATG KNECDVCTDQ LFGAARQDDP TLISQNSRFS SWEVICDSLD DYNRRVTLCN GTSEGLLRRN QVGRNSEKLP TLKDVQDCLS LKKFDNPPFF QNSTFSFRNA LEGFDKANGI LDSQMMSLHN LVHSFLNGTS ALPHSAANDP IFVHSAYK //