ID A0A5Z9QYL0_SALET Unreviewed; 729 AA. AC A0A5Z9QYL0; DT 22-APR-2020, integrated into UniProtKB/TrEMBL. DT 22-APR-2020, sequence version 1. DT 10-FEB-2021, entry version 6. DE RecName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000256|ARBA:ARBA00013000}; DE EC=1.1.1.35 {ECO:0000256|ARBA:ARBA00013000}; GN Name=fadB {ECO:0000313|EMBL:ECB5300441.1}; GN ORFNames=AUA42_21275 {ECO:0000313|EMBL:EBV9836563.1}, D3D97_23335 GN {ECO:0000313|EMBL:ECV0369698.1}, DBZ74_22095 GN {ECO:0000313|EMBL:TAD54701.1}, DPD93_17155 GN {ECO:0000313|EMBL:EBS3628613.1}, EYJ84_22250 GN {ECO:0000313|EMBL:ECB5300441.1}, H9S94_23545 GN {ECO:0000313|EMBL:QNN37625.1}; OS Salmonella enterica subsp. enterica serovar Albany. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Salmonella. OX NCBI_TaxID=211968 {ECO:0000313|EMBL:ECB5300441.1, ECO:0000313|Proteomes:UP000337743}; RN [1] {ECO:0000313|EMBL:TAD54701.1, ECO:0000313|Proteomes:UP000293700} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Sg_wb24 {ECO:0000313|EMBL:TAD54701.1}, and sg_wb24 RC {ECO:0000313|Proteomes:UP000293700}; RA Kohli G.S., Zwe Y.H., Ding Y., Givskov M., Liang Y.; RT "Comparative genomic analysis of various Salmonella enterica serotypes in RT Singapore."; RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:EBS3628613.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=238461 {ECO:0000313|EMBL:EBS3628613.1}; RA Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:ECB5300441.1, ECO:0000313|Proteomes:UP000337743} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CVM-N26076 {ECO:0000313|EMBL:EBV9836563.1}, FSIS11917612 RC {ECO:0000313|EMBL:ECB5300441.1, ECO:0000313|Proteomes:UP000337743}, RC and FSIS21822039 {ECO:0000313|EMBL:ECV0369698.1}; RG GenomeTrakr network: Whole genome sequencing for foodborne pathogen traceback; RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:QNN37625.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=R17.5974 {ECO:0000313|EMBL:QNN37625.1}; RA Chiou C.-S., Hong Y.-P., Wang Y.-W., Chen Y.-S.; RT "Salmonella enterica subsp. enterica serovar Albany strain R19.5974."; RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=a (3S)-3-hydroxy-fatty acyl-CoA + NAD(+) = a 3-oxoacyl-CoA + CC H(+) + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, CC ChEBI:CHEBI:90726; EC=1.1.1.35; CC Evidence={ECO:0000256|ARBA:ARBA00023693}; CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation. CC {ECO:0000256|ARBA:ARBA00005005}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAGVHF010000021; EBS3628613.1; -; Genomic_DNA. DR EMBL; AAHGYV010000131; EBV9836563.1; -; Genomic_DNA. DR EMBL; AAHXWF010000013; ECB5300441.1; -; Genomic_DNA. DR EMBL; AAKSWE010000038; ECV0369698.1; -; Genomic_DNA. DR EMBL; CP060730; QNN37625.1; -; Genomic_DNA. DR EMBL; QAUU01000104; TAD54701.1; -; Genomic_DNA. DR RefSeq; WP_023241747.1; NZ_RQSE01000017.1. DR UniPathway; UPA00659; -. DR Proteomes; UP000293700; Unassembled WGS sequence. DR Proteomes; UP000337743; Unassembled WGS sequence. DR GO; GO:0036125; C:fatty acid beta-oxidation multienzyme complex; IEA:InterPro. DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC. DR GO; GO:0008692; F:3-hydroxybutyryl-CoA epimerase activity; IEA:InterPro. DR GO; GO:0004165; F:dodecenoyl-CoA delta-isomerase activity; IEA:InterPro. DR GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:InterPro. DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway. DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd. DR InterPro; IPR006108; 3HC_DH_C. DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf. DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf. DR InterPro; IPR001753; Enoyl-CoA_hydra/iso. DR InterPro; IPR012799; FadB. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR Pfam; PF00725; 3HCDH; 2. DR Pfam; PF02737; 3HCDH_N; 1. DR Pfam; PF00378; ECH_1; 1. DR SUPFAM; SSF48179; SSF48179; 2. DR SUPFAM; SSF51735; SSF51735; 1. DR SUPFAM; SSF52096; SSF52096; 1. DR TIGRFAMs; TIGR02437; FadB; 1. PE 4: Predicted; KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832}; KW Isomerase {ECO:0000256|ARBA:ARBA00023235}; KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963}; KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098}; KW Lyase {ECO:0000256|ARBA:ARBA00023239}; KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268}; KW NAD {ECO:0000256|ARBA:ARBA00023027}; KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}. FT DOMAIN 316..494 FT /note="3HCDH_N" FT /evidence="ECO:0000259|Pfam:PF02737" FT DOMAIN 496..592 FT /note="3HCDH" FT /evidence="ECO:0000259|Pfam:PF00725" FT DOMAIN 627..690 FT /note="3HCDH" FT /evidence="ECO:0000259|Pfam:PF00725" FT REGION 708..729 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 729 AA; 79598 MW; 92F9FE07364E13BE CRC64; MLYKGDTLYL DWLEDGIAEL VFDASGSVNK LDTATVASLG QALEVLEKQH DLKGLLLRSN KAAFIVGADI TEFLSLFLVP EEQLSQWLHF ANSVFNRLED LPVPTLAAVN GYALGGGCEC VLATDYRLAT PDLRIGLPET KLGIMPGFGG SVRLPRMLGA DSALEIIAAG KDVGAEHALK IGLVDGVVKQ EKLIEGAIAV LRQAITGDLD WRAKRQPKLE PLKLSKIEAA MSFTIAKGMV AQTAGKHYPA PMTAVKTIEA AARFGREEAL NLENKSFVPL AHTNEARALV GIFLNDQYVK GKAKKLTKDI ETPKQAAVLG AGIMGGGIAY QSAWKGVPVI MKDINDKSLN LGMTEAAKLL NKQLERGKID GLKLAGVIST IHPTLDYAGF DRVDVVVEAV VENPKVKKAV LAETEQKVRP ETVLASNTST IPIGELASAL ERPENFCGMH FFNPVHRMPL VEIIRGEKSS DETIAKVVAW ASKMGKTPIV VNDCPGFFVN RVLFPYFAGF SQLLRDGADF RKVDKVMEKQ FGWPMGPAYL LDVVGIDTAH HAQAVMAAGF PQRMQKEYRD AIDALFDASR FGQKNGLGFW RYKEDSKGKP KKEEDAAVDD LLASVSQPKR DFSDDEIIAR MMIPMINEVV RCLEEGIIAS PAEADMALVY GLGFPPFHGG AFRWLDTQGS AKYLDMAQQY QHLGPLYEVP EGLRNKARHN EPYYPPVEPA RPVGSLKTA //