ID   A0A5Z9QYL0_SALET        Unreviewed;       729 AA.
AC   A0A5Z9QYL0;
DT   22-APR-2020, integrated into UniProtKB/TrEMBL.
DT   22-APR-2020, sequence version 1.
DT   10-FEB-2021, entry version 6.
DE   RecName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000256|ARBA:ARBA00013000};
DE            EC=1.1.1.35 {ECO:0000256|ARBA:ARBA00013000};
GN   Name=fadB {ECO:0000313|EMBL:ECB5300441.1};
GN   ORFNames=AUA42_21275 {ECO:0000313|EMBL:EBV9836563.1}, D3D97_23335
GN   {ECO:0000313|EMBL:ECV0369698.1}, DBZ74_22095
GN   {ECO:0000313|EMBL:TAD54701.1}, DPD93_17155
GN   {ECO:0000313|EMBL:EBS3628613.1}, EYJ84_22250
GN   {ECO:0000313|EMBL:ECB5300441.1}, H9S94_23545
GN   {ECO:0000313|EMBL:QNN37625.1};
OS   Salmonella enterica subsp. enterica serovar Albany.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=211968 {ECO:0000313|EMBL:ECB5300441.1, ECO:0000313|Proteomes:UP000337743};
RN   [1] {ECO:0000313|EMBL:TAD54701.1, ECO:0000313|Proteomes:UP000293700}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sg_wb24 {ECO:0000313|EMBL:TAD54701.1}, and sg_wb24
RC   {ECO:0000313|Proteomes:UP000293700};
RA   Kohli G.S., Zwe Y.H., Ding Y., Givskov M., Liang Y.;
RT   "Comparative genomic analysis of various Salmonella enterica serotypes in
RT   Singapore.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EBS3628613.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=238461 {ECO:0000313|EMBL:EBS3628613.1};
RA   Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ECB5300441.1, ECO:0000313|Proteomes:UP000337743}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CVM-N26076 {ECO:0000313|EMBL:EBV9836563.1}, FSIS11917612
RC   {ECO:0000313|EMBL:ECB5300441.1, ECO:0000313|Proteomes:UP000337743},
RC   and FSIS21822039 {ECO:0000313|EMBL:ECV0369698.1};
RG   GenomeTrakr network: Whole genome sequencing for foodborne pathogen traceback;
RL   Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:QNN37625.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=R17.5974 {ECO:0000313|EMBL:QNN37625.1};
RA   Chiou C.-S., Hong Y.-P., Wang Y.-W., Chen Y.-S.;
RT   "Salmonella enterica subsp. enterica serovar Albany strain R19.5974.";
RL   Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxy-fatty acyl-CoA + NAD(+) = a 3-oxoacyl-CoA +
CC         H(+) + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
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DR   EMBL; AAGVHF010000021; EBS3628613.1; -; Genomic_DNA.
DR   EMBL; AAHGYV010000131; EBV9836563.1; -; Genomic_DNA.
DR   EMBL; AAHXWF010000013; ECB5300441.1; -; Genomic_DNA.
DR   EMBL; AAKSWE010000038; ECV0369698.1; -; Genomic_DNA.
DR   EMBL; CP060730; QNN37625.1; -; Genomic_DNA.
DR   EMBL; QAUU01000104; TAD54701.1; -; Genomic_DNA.
DR   RefSeq; WP_023241747.1; NZ_RQSE01000017.1.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000293700; Unassembled WGS sequence.
DR   Proteomes; UP000337743; Unassembled WGS sequence.
DR   GO; GO:0036125; C:fatty acid beta-oxidation multienzyme complex; IEA:InterPro.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008692; F:3-hydroxybutyryl-CoA epimerase activity; IEA:InterPro.
DR   GO; GO:0004165; F:dodecenoyl-CoA delta-isomerase activity; IEA:InterPro.
DR   GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR012799; FadB.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   TIGRFAMs; TIGR02437; FadB; 1.
PE   4: Predicted;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          316..494
FT                   /note="3HCDH_N"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          496..592
FT                   /note="3HCDH"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          627..690
FT                   /note="3HCDH"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   REGION          708..729
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   729 AA;  79598 MW;  92F9FE07364E13BE CRC64;
     MLYKGDTLYL DWLEDGIAEL VFDASGSVNK LDTATVASLG QALEVLEKQH DLKGLLLRSN
     KAAFIVGADI TEFLSLFLVP EEQLSQWLHF ANSVFNRLED LPVPTLAAVN GYALGGGCEC
     VLATDYRLAT PDLRIGLPET KLGIMPGFGG SVRLPRMLGA DSALEIIAAG KDVGAEHALK
     IGLVDGVVKQ EKLIEGAIAV LRQAITGDLD WRAKRQPKLE PLKLSKIEAA MSFTIAKGMV
     AQTAGKHYPA PMTAVKTIEA AARFGREEAL NLENKSFVPL AHTNEARALV GIFLNDQYVK
     GKAKKLTKDI ETPKQAAVLG AGIMGGGIAY QSAWKGVPVI MKDINDKSLN LGMTEAAKLL
     NKQLERGKID GLKLAGVIST IHPTLDYAGF DRVDVVVEAV VENPKVKKAV LAETEQKVRP
     ETVLASNTST IPIGELASAL ERPENFCGMH FFNPVHRMPL VEIIRGEKSS DETIAKVVAW
     ASKMGKTPIV VNDCPGFFVN RVLFPYFAGF SQLLRDGADF RKVDKVMEKQ FGWPMGPAYL
     LDVVGIDTAH HAQAVMAAGF PQRMQKEYRD AIDALFDASR FGQKNGLGFW RYKEDSKGKP
     KKEEDAAVDD LLASVSQPKR DFSDDEIIAR MMIPMINEVV RCLEEGIIAS PAEADMALVY
     GLGFPPFHGG AFRWLDTQGS AKYLDMAQQY QHLGPLYEVP EGLRNKARHN EPYYPPVEPA
     RPVGSLKTA
//