ID   A0A5Z9QYL0_SALET        Unreviewed;       729 AA.
AC   A0A5Z9QYL0;
DT   22-APR-2020, integrated into UniProtKB/TrEMBL.
DT   22-APR-2020, sequence version 1.
DT   17-JUN-2020, entry version 2.
DE   RecName: Full=Fatty acid oxidation complex subunit alpha {ECO:0000256|SAAS:SAAS00051741};
GN   Name=fadB {ECO:0000313|EMBL:ECT1630628.1};
GN   ORFNames=ASI01_22220 {ECO:0000313|EMBL:EBV9363841.1}, AUA42_21275
GN   {ECO:0000313|EMBL:EBV9836563.1}, B1Q47_19265
GN   {ECO:0000313|EMBL:EBW9140889.1}, D3D97_23335
GN   {ECO:0000313|EMBL:ECV0369698.1}, DBZ74_22095
GN   {ECO:0000313|EMBL:TAD54701.1}, DPD93_17155
GN   {ECO:0000313|EMBL:EBS3628613.1}, DSM45_21335
GN   {ECO:0000313|EMBL:EBX5368181.1}, DVE65_24040
GN   {ECO:0000313|EMBL:ECT1630628.1}, EYJ84_22250
GN   {ECO:0000313|EMBL:ECB5300441.1};
OS   Salmonella enterica subsp. enterica serovar Albany.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=211968 {ECO:0000313|EMBL:ECT1630628.1};
RN   [1] {ECO:0000313|EMBL:TAD54701.1, ECO:0000313|Proteomes:UP000293700}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sg_wb24 {ECO:0000313|EMBL:TAD54701.1}, and sg_wb24
RC   {ECO:0000313|Proteomes:UP000293700};
RA   Kohli G.S., Zwe Y.H., Ding Y., Givskov M., Liang Y.;
RT   "Comparative genomic analysis of various Salmonella enterica serotypes in
RT   Singapore.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EBS3628613.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=238461 {ECO:0000313|EMBL:EBS3628613.1}, and 500293
RC   {ECO:0000313|EMBL:EBX5368181.1};
RA   Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ECT1630628.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ADRDL-953 {ECO:0000313|EMBL:EBW9140889.1}, CVM-N26076
RC   {ECO:0000313|EMBL:EBV9836563.1}, FSIS11917612
RC   {ECO:0000313|EMBL:ECB5300441.1, ECO:0000313|Proteomes:UP000337743},
RC   FSIS21822039 {ECO:0000313|EMBL:ECV0369698.1}, FSIS31800757
RC   {ECO:0000313|EMBL:ECT1630628.1}, and NY-N20024
RC   {ECO:0000313|EMBL:EBV9363841.1};
RG   GenomeTrakr network: Whole genome sequencing for foodborne pathogen traceback;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the aerobic and anaerobic degradation of long-
CC       chain fatty acids via beta-oxidation cycle. Catalyzes the formation of
CC       3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use
CC       D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
CC       {ECO:0000256|SAAS:SAAS00051718}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(3S)-hydroxybutanoyl-CoA = (3R)-hydroxybutanoyl-CoA;
CC         Xref=Rhea:RHEA:21760, ChEBI:CHEBI:57315, ChEBI:CHEBI:57316;
CC         EC=5.1.2.3; Evidence={ECO:0000256|SAAS:SAAS01121794};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA;
CC         Xref=Rhea:RHEA:45228, ChEBI:CHEBI:58521, ChEBI:CHEBI:85097;
CC         EC=5.3.3.8; Evidence={ECO:0000256|SAAS:SAAS01132199};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O;
CC         Xref=Rhea:RHEA:16105, ChEBI:CHEBI:15377, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:58856; EC=4.2.1.17;
CC         Evidence={ECO:0000256|SAAS:SAAS01133165};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA;
CC         Xref=Rhea:RHEA:45900, ChEBI:CHEBI:85097, ChEBI:CHEBI:85489;
CC         EC=5.3.3.8; Evidence={ECO:0000256|SAAS:SAAS01132197};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 4-saturated-(3S)-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O;
CC         Xref=Rhea:RHEA:20724, ChEBI:CHEBI:15377, ChEBI:CHEBI:58521,
CC         ChEBI:CHEBI:137480; EC=4.2.1.17;
CC         Evidence={ECO:0000256|SAAS:SAAS01123900};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains (FadB) and two beta chains
CC       (FadA). {ECO:0000256|SAAS:SAAS00051733}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the 3-hydroxyacyl-CoA
CC       dehydrogenase family. {ECO:0000256|SAAS:SAAS00556605}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the enoyl-CoA
CC       hydratase/isomerase family. {ECO:0000256|SAAS:SAAS00556608}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ECT1630628.1}.
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DR   EMBL; AAGVHF010000021; EBS3628613.1; -; Genomic_DNA.
DR   EMBL; AAHGVA010000040; EBV9363841.1; -; Genomic_DNA.
DR   EMBL; AAHGYV010000131; EBV9836563.1; -; Genomic_DNA.
DR   EMBL; AAHJQZ010000016; EBW9140889.1; -; Genomic_DNA.
DR   EMBL; AAHLNX010000142; EBX5368181.1; -; Genomic_DNA.
DR   EMBL; AAHXWF010000013; ECB5300441.1; -; Genomic_DNA.
DR   EMBL; AAKLWV010000097; ECT1630628.1; -; Genomic_DNA.
DR   EMBL; AAKSWE010000038; ECV0369698.1; -; Genomic_DNA.
DR   EMBL; QAUU01000104; TAD54701.1; -; Genomic_DNA.
DR   RefSeq; WP_023241747.1; NZ_RQSE01000017.1.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000293700; Unassembled WGS sequence.
DR   Proteomes; UP000337743; Unassembled WGS sequence.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR012799; FadB.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   TIGRFAMs; TIGR02437; FadB; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Isomerase {ECO:0000256|SAAS:SAAS00442736};
KW   Lipid degradation {ECO:0000256|SAAS:SAAS00256736};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   Lyase {ECO:0000256|SAAS:SAAS00999128};
KW   Multifunctional enzyme {ECO:0000256|SAAS:SAAS00999134};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296}.
FT   DOMAIN          316..494
FT                   /note="3HCDH_N"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          496..592
FT                   /note="3HCDH"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          627..689
FT                   /note="3HCDH"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   REGION          708..729
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   729 AA;  79598 MW;  92F9FE07364E13BE CRC64;
     MLYKGDTLYL DWLEDGIAEL VFDASGSVNK LDTATVASLG QALEVLEKQH DLKGLLLRSN
     KAAFIVGADI TEFLSLFLVP EEQLSQWLHF ANSVFNRLED LPVPTLAAVN GYALGGGCEC
     VLATDYRLAT PDLRIGLPET KLGIMPGFGG SVRLPRMLGA DSALEIIAAG KDVGAEHALK
     IGLVDGVVKQ EKLIEGAIAV LRQAITGDLD WRAKRQPKLE PLKLSKIEAA MSFTIAKGMV
     AQTAGKHYPA PMTAVKTIEA AARFGREEAL NLENKSFVPL AHTNEARALV GIFLNDQYVK
     GKAKKLTKDI ETPKQAAVLG AGIMGGGIAY QSAWKGVPVI MKDINDKSLN LGMTEAAKLL
     NKQLERGKID GLKLAGVIST IHPTLDYAGF DRVDVVVEAV VENPKVKKAV LAETEQKVRP
     ETVLASNTST IPIGELASAL ERPENFCGMH FFNPVHRMPL VEIIRGEKSS DETIAKVVAW
     ASKMGKTPIV VNDCPGFFVN RVLFPYFAGF SQLLRDGADF RKVDKVMEKQ FGWPMGPAYL
     LDVVGIDTAH HAQAVMAAGF PQRMQKEYRD AIDALFDASR FGQKNGLGFW RYKEDSKGKP
     KKEEDAAVDD LLASVSQPKR DFSDDEIIAR MMIPMINEVV RCLEEGIIAS PAEADMALVY
     GLGFPPFHGG AFRWLDTQGS AKYLDMAQQY QHLGPLYEVP EGLRNKARHN EPYYPPVEPA
     RPVGSLKTA
//