ID A0A5R1WYM5_9BURK Unreviewed; 630 AA. AC A0A5R1WYM5; DT 26-FEB-2020, integrated into UniProtKB/TrEMBL. DT 26-FEB-2020, sequence version 1. DT 03-AUG-2022, entry version 7. DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149}; GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149, GN ECO:0000313|EMBL:TFI08863.1}; GN ORFNames=E4P32_12085 {ECO:0000313|EMBL:TFI08863.1}; OS Herbaspirillum sp. 3R11. OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Oxalobacteraceae; Herbaspirillum; unclassified Herbaspirillum. OX NCBI_TaxID=2559617 {ECO:0000313|EMBL:TFI08863.1, ECO:0000313|Proteomes:UP000297324}; RN [1] {ECO:0000313|EMBL:TFI08863.1, ECO:0000313|Proteomes:UP000297324} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=3R11 {ECO:0000313|EMBL:TFI08863.1, RC ECO:0000313|Proteomes:UP000297324}; RA Swanson E., Sevigny J.L., Pesce C., Davis I., Kleiner V., Tisa L.; RT "Genome Sequencing and Assembly of Various Microbes Isolated from Alder RT Root Nodule."; RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA. CC It is required for dam-dependent methyl-directed DNA mismatch repair. CC May act as a 'molecular matchmaker', a protein that promotes the CC formation of a stable complex between two or more DNA-binding proteins CC in an ATP-dependent manner without itself being part of a final CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}. CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family. CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:TFI08863.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; SPNJ01000002; TFI08863.1; -; Genomic_DNA. DR Proteomes; UP000297324; Unassembled WGS sequence. DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro. DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro. DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW. DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro. DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule. DR Gene3D; 3.30.1370.100; -; 1. DR Gene3D; 3.30.1540.20; -; 1. DR Gene3D; 3.30.230.10; -; 1. DR Gene3D; 3.30.565.10; -; 1. DR HAMAP; MF_00149; DNA_mis_repair; 1. DR InterPro; IPR014762; DNA_mismatch_repair_CS. DR InterPro; IPR020667; DNA_mismatch_repair_MutL. DR InterPro; IPR002099; DNA_mismatch_repair_N. DR InterPro; IPR013507; DNA_mismatch_S5_2-like. DR InterPro; IPR036890; HATPase_C_sf. DR InterPro; IPR038973; MutL/Mlh/Pms. DR InterPro; IPR014790; MutL_C. DR InterPro; IPR042120; MutL_C_dimsub. DR InterPro; IPR042121; MutL_C_regsub. DR InterPro; IPR037198; MutL_C_sf. DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold. DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr. DR PANTHER; PTHR10073; PTHR10073; 1. DR Pfam; PF01119; DNA_mis_repair; 1. DR Pfam; PF08676; MutL_C; 1. DR SMART; SM01340; DNA_mis_repair; 1. DR SMART; SM00853; MutL_C; 1. DR SUPFAM; SSF118116; SSF118116; 1. DR SUPFAM; SSF54211; SSF54211; 1. DR SUPFAM; SSF55874; SSF55874; 1. DR TIGRFAMs; TIGR00585; mutl; 1. DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1. PE 3: Inferred from homology; KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP- KW Rule:MF_00149}; KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP- KW Rule:MF_00149}; Endonuclease {ECO:0000313|EMBL:TFI08863.1}; KW Hydrolase {ECO:0000313|EMBL:TFI08863.1}; KW Nuclease {ECO:0000313|EMBL:TFI08863.1}. FT DOMAIN 216..334 FT /note="DNA_mis_repair" FT /evidence="ECO:0000259|SMART:SM01340" FT DOMAIN 443..586 FT /note="MutL_C" FT /evidence="ECO:0000259|SMART:SM00853" FT REGION 342..369 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 630 AA; 68415 MW; 997EF2E45EE1776D CRC64; MNAPDRPPRP IRPIQALPDQ LISQIAAGEV IERPSAVVKE LLENALDAGA TQITVRLEQG GVKRIAITDN GRGIPPEQMP LALARHATSK IASLTDLENV GTLGFRGEAL ASIASVAQLT LTTRTADAAH AWEIIGSQEG SVVPASGAPG TTIDVQDLYF NTPARRKFLK SEQTEYGHCA EVVRRIALAR PDVTFSLTHN GKTVDHWNTG EFAKRSAHIL GDEFANARLP LDESAGPLRL HGFVGLPTAS KARADGQYFY VNGRFVRDKL LVHAVRAAYQ DVLHGDRYPS YALSLDLDPA LVDVNVHPSK IEVRFRDSRS VHQFVFHAVS RALAATSATS FGNAPAPQAA GNGPLPWMRD QQSQPQPQYQ NEFGAQLRPN FSAGNFGVAQ NTAEYGAMFR PGEQTNLDMA STFGSEAAPG AFTIPTSPNT QTLPTDDFPL GFALAQLHGI YVLAQNSKGL VVVDMHAAHE RILYEQLKNA LDDNSMFVQP LLIPVTFYAD AVEVGTVEEH QETLSALGFD IAAMSPTTLA VRAVPALLKN ADAQTLARDV LRDVREFGGS RVLLERRNEL LGTLACHTAV RANRSLTVPE MNALLRQMEA TERADQCNHG RPTWSQLALS DMDKLFLRGQ //