ID A0A5P9K6L9_9NIDO Unreviewed; 2341 AA. AC A0A5P9K6L9; DT 26-FEB-2020, integrated into UniProtKB/TrEMBL. DT 26-FEB-2020, sequence version 1. DT 27-NOV-2024, entry version 23. DE RecName: Full=Replicase polyprotein 1ab {ECO:0000256|ARBA:ARBA00022087}; DE AltName: Full=ORF1ab polyprotein {ECO:0000256|ARBA:ARBA00029611}; GN Name=ORF1B {ECO:0000313|EMBL:QFU19787.1}; OS Serpentovirinae sp. OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; OC Nidovirales; Tornidovirineae; Tobaniviridae; Serpentovirinae. OX NCBI_TaxID=2661817 {ECO:0000313|EMBL:QFU19787.1}; RN [1] {ECO:0000313|EMBL:QFU19787.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=L4 {ECO:0000313|EMBL:QFU19787.1}; RX PubMed=31632990; RA Hoon-Hanks L.L., Ossiboff R.J., Bartolini P., Fogelson S.B., Perry S.M., RA Stohr A.C., Cross S.T., Wellehan J.F.X., Jacobson E.R., Dubovi E.J., RA Stenglein M.D.; RT "Longitudinal and Cross-Sectional Sampling of Serpentovirus (Nidovirus) RT Infection in Captive Snakes Reveals High Prevalence, Persistent Infection, RT and Increased Mortality in Pythons and Divergent Serpentovirus Infection in RT Boas and Colubrids."; RL Front Vet Sci 6:338-338(2019). RN [2] {ECO:0000313|EMBL:QFU19787.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=L4 {ECO:0000313|EMBL:QFU19787.1}; RA Hoon-Hanks L., Stenglein M.D.; RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; CC Evidence={ECO:0000256|ARBA:ARBA00001665}; CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; CC Evidence={ECO:0000256|ARBA:ARBA00001556}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MN161569; QFU19787.1; -; Genomic_RNA. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro. DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:TreeGrafter. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule. DR GO; GO:0004483; F:mRNA (nucleoside-2'-O-)-methyltransferase activity; IEA:InterPro. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro. DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW. DR GO; GO:0075523; P:viral translational frameshifting; IEA:UniProtKB-KW. DR CDD; cd20762; capping_2-OMTase_Nidovirales; 1. DR CDD; cd23186; Tobaniviridae_RdRp; 1. DR CDD; cd21403; ZBD_tv_SF1_Hel-like; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2. DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1. DR InterPro; IPR050534; Coronavir_polyprotein_1ab. DR InterPro; IPR043502; DNA/RNA_pol_sf. DR InterPro; IPR037227; EndoU-like. DR InterPro; IPR043609; NendoU_nidovirus. DR InterPro; IPR044863; NIRAN. DR InterPro; IPR046438; NIV_2_O_MTASE. DR InterPro; IPR046436; NIV_EXON. DR InterPro; IPR027352; NSP13_ZBD_CoV-like. DR InterPro; IPR009461; NSP16_CoV-like. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR001205; RNA-dir_pol_C. DR InterPro; IPR029063; SAM-dependent_MTases_sf. DR InterPro; IPR044336; SF1_Hel_ZBD_tv. DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1. DR PANTHER; PTHR43788:SF8; HELICASE WITH ZINC FINGER 2; 1. DR Pfam; PF13245; AAA_19; 1. DR Pfam; PF06460; CoV_Methyltr_2; 1. DR Pfam; PF19215; CoV_NSP15_C; 1. DR Pfam; PF00680; RdRP_1; 1. DR SUPFAM; SSF56672; DNA/RNA polymerases; 1. DR SUPFAM; SSF142877; EndoU-like; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2. DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1. DR PROSITE; PS51653; CV_ZBD; 1. DR PROSITE; PS51958; NENDOU; 1. DR PROSITE; PS51947; NIRAN; 1. DR PROSITE; PS51955; NIV_2_O_MTASE; 1. DR PROSITE; PS51953; NIV_EXON; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|PROSITE- KW ProRule:PRU01303}; KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PROSITE- KW ProRule:PRU01298}; Helicase {ECO:0000256|ARBA:ARBA00022806}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE- KW ProRule:PRU01303}; Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603}; KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PROSITE- KW ProRule:PRU01298}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695}; KW Protease {ECO:0000256|ARBA:ARBA00022807}; KW Ribosomal frameshifting {ECO:0000256|ARBA:ARBA00022758}; KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484}; KW Thiol protease {ECO:0000256|ARBA:ARBA00022807}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}; KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}. FT DOMAIN 46..275 FT /note="NiRAN" FT /evidence="ECO:0000259|PROSITE:PS51947" FT DOMAIN 884..972 FT /note="CV ZBD" FT /evidence="ECO:0000259|PROSITE:PS51653" FT DOMAIN 1430..1654 FT /note="ExoN" FT /evidence="ECO:0000259|PROSITE:PS51953" FT DOMAIN 1919..2053 FT /note="NendoU" FT /evidence="ECO:0000259|PROSITE:PS51958" FT DOMAIN 2069..2341 FT /note="Nidovirus-type SAM-dependent 2'-O-MTase" FT /evidence="ECO:0000259|PROSITE:PS51955" FT REGION 1..32 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..18 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT ACT_SITE 1457 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01298" FT ACT_SITE 1459 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01298" FT ACT_SITE 1560 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01298" FT ACT_SITE 1633 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01298" FT ACT_SITE 1638 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01298" FT ACT_SITE 1947 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01303" FT ACT_SITE 1964 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01303" FT ACT_SITE 1998 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01303" SQ SEQUENCE 2341 AA; 266091 MW; 41A2A02E00CF187F CRC64; MQLKPNKPST QGKNNDACRQ APRNAPAGKK LVSSAVKQVT GDFELVSRQV SDILQKPDIY FGLRGDEQPD SKGRWVNVCQ QDSGIKRLQK CRTISIEINH RNHMLKTGSE KSLRHEYNQY LVLKDSIAIP EHQLVKLDNG SYVLIRGPVS NDSLGDLVYS HFHNSNEEAP EIPDKGKPSA QAICDALAER LEPAFENLDR LRAWCLKYNV QLPITLDNID MNGQLYDFED INTSPHNIDI ALSDFMRLWS LTNRPPPEVA KKWFPVKYNL HECSWLEKVL QVNNNLLHAK NTNTEIFIDA SSNTTSMYHN DVTGTHTIDS EQLNSCSDFL QNLYYLQDPG LHWRKPVITV GNRVNFAATT DNHETPANRP VYYNEEAFNF FESRLGNIDS VLDYTYFQGD NANCVNDFLY YDYQGRLFLQ PHLVKFLYER TRKDFSSCAT DVRFSKLECT PRKSSLGPSH TLLRSYKQDQ IYTAAPDNFI EELVNLSEQS ALIFSTKCVQ KFALTAKPRA RTIAACSMTA STLFRALHKP VTANFVTQTQ KQGTEIHHLI GVSKFRGGFH NWFTSRHGDI SNWKVFGSDY TKCDRSFPLV FRSMAAALLF DLGGWDPHSH HFTNEMHAFM FDIVHLDGKL VYKPGGTSSG DATTAFANTL YNHGVHLLVQ LQTLVTQQVH QNHLALKVAA VKGFQTGDFD DYNAMLDHYN KTQYKFNFLS DDSFILTNIH DKTLPDIYNK HNFSKHLETI IHTTVDQNKA WESEGDLHEF CSSTVKPCNG ILQYIPDKHR LLAALCIEGK ASTAELRVVR IAAILAEGVI YSQVDLNFWR VLWEYFENQL AEFIEQYGVL PIPDKMTEAE FYYGLIDPDK SPSDMELFQS VLADWGIKDV EMQAKNQVQQ QCYTCHNPTV STCIDCPVAY PLCCYCACTH YNETGHKVTH LPVCSHPGCG MSDPECMNFS LDNGQFTIRC DEHNTTFSIK VYDNKTQSFR LPLNQYCVKQ ESTVSNISKT IDNFTEGDFF SWNVEESKTS NMTRLLHESY LNDQYSAEQD IIFDYTVLDI KNNEVMIKDA SYGLTTYCNI LDSNGKIKLN CTVDPLRKDV YRLTFLDDTK RFINFDKIQR SNRVASKTDL SLLDVFKRTK FILGPPGTGK TTYFIENYFS KQRHNKVVYA APTHKLVQDM DEALKGNSNV TVYKGKYNNR EYHAPIDDES KPLVLCTVNI VRPIAGCVLL IDECSLLSPK QLFDAIIRSR AGEVICVGDP FQLSPVTPVT DFCWDYETFY LRQLVPQYNQ TVLSTCYRCP RNIFNIFAGA YHNHNIEFNA AKEGGIVNWH RLKNDGIVIS QKVLQEADNA GLDIVLVNYK QAAIDALNLK TRFVTIDSAQ GLTVGKVGVI IFGSTKFSKV LNRLIVATSR ATQQLDIWCC ASVEDHIREH LCTKTVTPQA LLTRPNCLTE IDIQTLASNI EATAVCDIEF YHAKHPTRST PNFLGLGEIN CLTSRSTTTF LRPHYNRDGD YLEVEDSYIR VSKEWKYMLR HLPNYVDSDM RRNHFLHFLN DTTNLSNSPL IFVLFNGTND LDALAEITTP AGTCHCGKPA RFTTNTDEDV CQEHCNGKFL VAVAGGMYFN IRSTSNLTTI HGVICGKYHG AAHNANNDVV MTACLLDDML KQHTPSTEGP TKHDEFGTWR KVKPCLDNPN DRVYGSTYYH KSSRVNTSNA GAISNQMPVN KEHTDSYVII PPAMRIKACH AVSRIHCCTA CLNHGKNWLK TNLANIQQGW QLEDSNFELQ LTQYEKQLKL SAEVIETPMG LRVRLGGHTG VTVNWQGSLD QTICKYNHEV NQPLPIKEVL NGLAINCTVN CSHHAVPITT EDRLNDWDTP LVVKPIQHKG TQYVCKPAGK GADNTKAFVL GMDDWVRVNY DELPRYQLTR LDNNVEVELE NTLYSTGRLA TQDYWTFPSE ESTDCAHIEL GDYNDSSLKI GGMHMFPKAF ENASLNKVEQ EASTPLWHAN IVAKQGTKLH NSLVDVEVTR FISTIKDKLT TNTISTRTTI RIDHQNIPIM IWATAGKIDT AYLQNGGPDV VLPATQKCSQ SYIQYKPVIR PYKTEVLMNS NIAHFEVLRN RLNQAANITK YVQLCNYLND NVKVPPKTRV LHLGAATGPE HDQIPVGGVV LNHFFTNCDV YHHDIRPINN CNGRFKVGLP EGKVDLIISD IWNYNEDTDG EWISNHEMLI NYVNQHLHLG GSIIWKTTRR SNLSYINYIA SHFGQVDYMT TRGNASSSEM FVVFKYFKQE IKQPQEKDRD CWQILHHLFA YRHQHRTYVR QDSLNCDTIS KHKSVYRVPK FLEGRIEKSS WASGNFIQQN S //