ID   A0A5P9K6L9_9NIDO        Unreviewed;      2341 AA.
AC   A0A5P9K6L9;
DT   26-FEB-2020, integrated into UniProtKB/TrEMBL.
DT   26-FEB-2020, sequence version 1.
DT   12-OCT-2022, entry version 14.
DE   RecName: Full=Replicase polyprotein 1ab {ECO:0000256|ARBA:ARBA00022087};
DE   AltName: Full=ORF1ab polyprotein {ECO:0000256|ARBA:ARBA00029611};
GN   Name=ORF1B {ECO:0000313|EMBL:QFU19787.1};
OS   Serpentovirinae sp.
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Tornidovirineae; Tobaniviridae; Serpentovirinae;
OC   unclassified Serpentovirinae.
OX   NCBI_TaxID=2661817 {ECO:0000313|EMBL:QFU19787.1};
RN   [1] {ECO:0000313|EMBL:QFU19787.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=L4 {ECO:0000313|EMBL:QFU19787.1};
RX   PubMed=31632990;
RA   Hoon-Hanks L.L., Ossiboff R.J., Bartolini P., Fogelson S.B., Perry S.M.,
RA   Stohr A.C., Cross S.T., Wellehan J.F.X., Jacobson E.R., Dubovi E.J.,
RA   Stenglein M.D.;
RT   "Longitudinal and Cross-Sectional Sampling of Serpentovirus (Nidovirus)
RT   Infection in Captive Snakes Reveals High Prevalence, Persistent Infection,
RT   and Increased Mortality in Pythons and Divergent Serpentovirus Infection in
RT   Boas and Colubrids.";
RL   Front Vet Sci 6:0-338(2019).
RN   [2] {ECO:0000313|EMBL:QFU19787.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=L4 {ECO:0000313|EMBL:QFU19787.1};
RA   Hoon-Hanks L., Stenglein M.D.;
RL   Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR   EMBL; MN161569; QFU19787.1; -; Genomic_RNA.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0004483; F:mRNA (nucleoside-2'-O-)-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   CDD; cd20762; capping_2-OMTase_Nidovirales; 1.
DR   CDD; cd21403; ZBD_tv_SF1_Hel-like; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR037227; EndoU-like.
DR   InterPro; IPR043609; NendoU_nidovirus.
DR   InterPro; IPR044863; NIRAN.
DR   InterPro; IPR046438; NIV_2_O_MTASE.
DR   InterPro; IPR046436; NIV_EXON.
DR   InterPro; IPR027352; NSP13_ZBD_CoV-like.
DR   InterPro; IPR009461; NSP16_CoV-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001205; RNA-dir_pol_C.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR044336; SF1_Hel_ZBD_tv.
DR   Pfam; PF06460; CoV_Methyltr_2; 1.
DR   Pfam; PF19215; CoV_NSP15_C; 1.
DR   Pfam; PF00680; RdRP_1; 1.
DR   SUPFAM; SSF142877; SSF142877; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS51653; CV_ZBD; 1.
DR   PROSITE; PS51958; NENDOU; 1.
DR   PROSITE; PS51947; NIRAN; 1.
DR   PROSITE; PS51955; NIV_2_O_MTASE; 1.
DR   PROSITE; PS51953; NIV_EXON; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022806};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|PROSITE-
KW   ProRule:PRU01303}; Exonuclease {ECO:0000256|PROSITE-ProRule:PRU01298};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01303}; Membrane {ECO:0000256|ARBA:ARBA00022870};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PROSITE-
KW   ProRule:PRU01298}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Ribosomal frameshifting {ECO:0000256|ARBA:ARBA00022758};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          46..275
FT                   /note="NiRAN"
FT                   /evidence="ECO:0000259|PROSITE:PS51947"
FT   DOMAIN          884..972
FT                   /note="CV ZBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51653"
FT   DOMAIN          1430..1654
FT                   /note="ExoN"
FT                   /evidence="ECO:0000259|PROSITE:PS51953"
FT   DOMAIN          1919..2053
FT                   /note="NendoU"
FT                   /evidence="ECO:0000259|PROSITE:PS51958"
FT   DOMAIN          2069..2341
FT                   /note="Nidovirus-type SAM-dependent 2'-O-MTase"
FT                   /evidence="ECO:0000259|PROSITE:PS51955"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        1457
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01298"
FT   ACT_SITE        1459
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01298"
FT   ACT_SITE        1560
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01298"
FT   ACT_SITE        1633
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01298"
FT   ACT_SITE        1638
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01298"
FT   ACT_SITE        1947
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01303"
FT   ACT_SITE        1964
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01303"
FT   ACT_SITE        1998
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01303"
SQ   SEQUENCE   2341 AA;  266091 MW;  41A2A02E00CF187F CRC64;
     MQLKPNKPST QGKNNDACRQ APRNAPAGKK LVSSAVKQVT GDFELVSRQV SDILQKPDIY
     FGLRGDEQPD SKGRWVNVCQ QDSGIKRLQK CRTISIEINH RNHMLKTGSE KSLRHEYNQY
     LVLKDSIAIP EHQLVKLDNG SYVLIRGPVS NDSLGDLVYS HFHNSNEEAP EIPDKGKPSA
     QAICDALAER LEPAFENLDR LRAWCLKYNV QLPITLDNID MNGQLYDFED INTSPHNIDI
     ALSDFMRLWS LTNRPPPEVA KKWFPVKYNL HECSWLEKVL QVNNNLLHAK NTNTEIFIDA
     SSNTTSMYHN DVTGTHTIDS EQLNSCSDFL QNLYYLQDPG LHWRKPVITV GNRVNFAATT
     DNHETPANRP VYYNEEAFNF FESRLGNIDS VLDYTYFQGD NANCVNDFLY YDYQGRLFLQ
     PHLVKFLYER TRKDFSSCAT DVRFSKLECT PRKSSLGPSH TLLRSYKQDQ IYTAAPDNFI
     EELVNLSEQS ALIFSTKCVQ KFALTAKPRA RTIAACSMTA STLFRALHKP VTANFVTQTQ
     KQGTEIHHLI GVSKFRGGFH NWFTSRHGDI SNWKVFGSDY TKCDRSFPLV FRSMAAALLF
     DLGGWDPHSH HFTNEMHAFM FDIVHLDGKL VYKPGGTSSG DATTAFANTL YNHGVHLLVQ
     LQTLVTQQVH QNHLALKVAA VKGFQTGDFD DYNAMLDHYN KTQYKFNFLS DDSFILTNIH
     DKTLPDIYNK HNFSKHLETI IHTTVDQNKA WESEGDLHEF CSSTVKPCNG ILQYIPDKHR
     LLAALCIEGK ASTAELRVVR IAAILAEGVI YSQVDLNFWR VLWEYFENQL AEFIEQYGVL
     PIPDKMTEAE FYYGLIDPDK SPSDMELFQS VLADWGIKDV EMQAKNQVQQ QCYTCHNPTV
     STCIDCPVAY PLCCYCACTH YNETGHKVTH LPVCSHPGCG MSDPECMNFS LDNGQFTIRC
     DEHNTTFSIK VYDNKTQSFR LPLNQYCVKQ ESTVSNISKT IDNFTEGDFF SWNVEESKTS
     NMTRLLHESY LNDQYSAEQD IIFDYTVLDI KNNEVMIKDA SYGLTTYCNI LDSNGKIKLN
     CTVDPLRKDV YRLTFLDDTK RFINFDKIQR SNRVASKTDL SLLDVFKRTK FILGPPGTGK
     TTYFIENYFS KQRHNKVVYA APTHKLVQDM DEALKGNSNV TVYKGKYNNR EYHAPIDDES
     KPLVLCTVNI VRPIAGCVLL IDECSLLSPK QLFDAIIRSR AGEVICVGDP FQLSPVTPVT
     DFCWDYETFY LRQLVPQYNQ TVLSTCYRCP RNIFNIFAGA YHNHNIEFNA AKEGGIVNWH
     RLKNDGIVIS QKVLQEADNA GLDIVLVNYK QAAIDALNLK TRFVTIDSAQ GLTVGKVGVI
     IFGSTKFSKV LNRLIVATSR ATQQLDIWCC ASVEDHIREH LCTKTVTPQA LLTRPNCLTE
     IDIQTLASNI EATAVCDIEF YHAKHPTRST PNFLGLGEIN CLTSRSTTTF LRPHYNRDGD
     YLEVEDSYIR VSKEWKYMLR HLPNYVDSDM RRNHFLHFLN DTTNLSNSPL IFVLFNGTND
     LDALAEITTP AGTCHCGKPA RFTTNTDEDV CQEHCNGKFL VAVAGGMYFN IRSTSNLTTI
     HGVICGKYHG AAHNANNDVV MTACLLDDML KQHTPSTEGP TKHDEFGTWR KVKPCLDNPN
     DRVYGSTYYH KSSRVNTSNA GAISNQMPVN KEHTDSYVII PPAMRIKACH AVSRIHCCTA
     CLNHGKNWLK TNLANIQQGW QLEDSNFELQ LTQYEKQLKL SAEVIETPMG LRVRLGGHTG
     VTVNWQGSLD QTICKYNHEV NQPLPIKEVL NGLAINCTVN CSHHAVPITT EDRLNDWDTP
     LVVKPIQHKG TQYVCKPAGK GADNTKAFVL GMDDWVRVNY DELPRYQLTR LDNNVEVELE
     NTLYSTGRLA TQDYWTFPSE ESTDCAHIEL GDYNDSSLKI GGMHMFPKAF ENASLNKVEQ
     EASTPLWHAN IVAKQGTKLH NSLVDVEVTR FISTIKDKLT TNTISTRTTI RIDHQNIPIM
     IWATAGKIDT AYLQNGGPDV VLPATQKCSQ SYIQYKPVIR PYKTEVLMNS NIAHFEVLRN
     RLNQAANITK YVQLCNYLND NVKVPPKTRV LHLGAATGPE HDQIPVGGVV LNHFFTNCDV
     YHHDIRPINN CNGRFKVGLP EGKVDLIISD IWNYNEDTDG EWISNHEMLI NYVNQHLHLG
     GSIIWKTTRR SNLSYINYIA SHFGQVDYMT TRGNASSSEM FVVFKYFKQE IKQPQEKDRD
     CWQILHHLFA YRHQHRTYVR QDSLNCDTIS KHKSVYRVPK FLEGRIEKSS WASGNFIQQN
     S
//