ID A0A5P8H8K5_LATMC Unreviewed; 142 AA. AC A0A5P8H8K5; DT 26-FEB-2020, integrated into UniProtKB/TrEMBL. DT 26-FEB-2020, sequence version 1. DT 27-NOV-2024, entry version 18. DE RecName: Full=Hypocretin neuropeptide precursor {ECO:0000256|ARBA:ARBA00034336}; DE AltName: Full=Hypocretin {ECO:0000256|ARBA:ARBA00034371}; DE AltName: Full=Orexin precursor {ECO:0000256|ARBA:ARBA00034351}; DE AltName: Full=Prepro-orexin {ECO:0000256|ARBA:ARBA00034367}; DE AltName: Full=Preprohypocretin {ECO:0000256|ARBA:ARBA00034354}; DE Flags: Fragment; GN Name=orx {ECO:0000313|EMBL:QFQ51512.1}; OS Lateolabrax maculatus (Spotted sea bass). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Acropomatiformes; Lateolabracidae; Lateolabrax. OX NCBI_TaxID=315492 {ECO:0000313|EMBL:QFQ51512.1}; RN [1] {ECO:0000313|EMBL:QFQ51512.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=31447787; DOI=.3389/fendo.2019.00545; RA Li Q., Wen H., Li Y., Zhang Z., Zhou Y., Qi X.; RT "Evidence for the Direct Effect of the NPFF Peptide on the Expression of RT Feeding-Related Factors in Spotted Sea Bass (Lateolabrax maculatus)."; RL Front. Endocrinol. 10:545-545(2019). CC -!- FUNCTION: Binds to orexin receptor HCRTR2/OX2R only. Stimulates food CC intake. Modulates pituitary luteinizing hormone secretion in an ovarian CC steroid-dependent manner. {ECO:0000256|ARBA:ARBA00046224}. CC -!- FUNCTION: Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a CC high affinity. Stimulates food intake. Modulates pituitary luteinizing CC hormone secretion in an ovarian steroid-dependent manner. CC {ECO:0000256|ARBA:ARBA00045659}. CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle CC {ECO:0000256|ARBA:ARBA00004541}. Rough endoplasmic reticulum CC {ECO:0000256|ARBA:ARBA00004427}. Synapse CC {ECO:0000256|ARBA:ARBA00034103}. CC -!- SIMILARITY: Belongs to the orexin family. CC {ECO:0000256|ARBA:ARBA00009198}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MK825880; QFQ51512.1; -; mRNA. DR AlphaFoldDB; A0A5P8H8K5; -. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:TreeGrafter. DR GO; GO:0005791; C:rough endoplasmic reticulum; IEA:UniProtKB-SubCell. DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:TreeGrafter. DR GO; GO:0031771; F:type 1 orexin receptor binding; IEA:TreeGrafter. DR GO; GO:0031772; F:type 2 orexin receptor binding; IEA:TreeGrafter. DR GO; GO:0042755; P:eating behavior; IEA:TreeGrafter. DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro. DR GO; GO:0051971; P:positive regulation of transmission of nerve impulse; IEA:TreeGrafter. DR GO; GO:0046928; P:regulation of neurotransmitter secretion; IEA:TreeGrafter. DR GO; GO:0042594; P:response to starvation; IEA:TreeGrafter. DR GO; GO:0030431; P:sleep; IEA:TreeGrafter. DR GO; GO:0001659; P:temperature homeostasis; IEA:TreeGrafter. DR InterPro; IPR001704; Orexin. DR PANTHER; PTHR15173; OREXIN; 1. DR PANTHER; PTHR15173:SF2; OREXIN; 1. DR Pfam; PF02072; Orexin; 1. PE 2: Evidence at transcript level; KW Amidation {ECO:0000256|ARBA:ARBA00022815}; KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329}; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824}; KW Neuropeptide {ECO:0000256|ARBA:ARBA00023320}; KW Pyrrolidone carboxylic acid {ECO:0000256|ARBA:ARBA00023283}; KW Signal {ECO:0000256|SAM:SignalP}; Synapse {ECO:0000256|ARBA:ARBA00023018}. FT SIGNAL 1..37 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 38..142 FT /note="Hypocretin neuropeptide precursor" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5024271929" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:QFQ51512.1" SQ SEQUENCE 142 AA; 15742 MW; 4A0E2F03C0F8AC2B CRC64; MTWFPTNFKK AAGMDMSNRK VLVLVLMLLL SQLACDAHRV SECCTQPSRS CRLYVLLCRS NSKYLGGPLT GDAAAGILTL GKRKEDEDRL QSRLHQLLHG SRNQAAGILT MGKRTEERAG EQYKDWMTQS GATITTLLPV LS //