ID A0A5P2UBZ6_KLULC Unreviewed; 523 AA. AC A0A5P2UBZ6; DT 22-APR-2020, integrated into UniProtKB/TrEMBL. DT 22-APR-2020, sequence version 1. DT 25-MAY-2022, entry version 6. DE RecName: Full=Acetyl-CoA hydrolase {ECO:0000256|ARBA:ARBA00017958}; DE EC=3.1.2.1 {ECO:0000256|ARBA:ARBA00011920}; DE AltName: Full=Acetyl-CoA deacylase {ECO:0000256|ARBA:ARBA00029672}; GN ORFNames=KDRO_F05850 {ECO:0000313|EMBL:QEU62654.1}; OS Kluyveromyces lactis (Yeast) (Candida sphaerica). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces. OX NCBI_TaxID=28985 {ECO:0000313|EMBL:QEU62654.1, ECO:0000313|Proteomes:UP000323107}; RN [1] {ECO:0000313|Proteomes:UP000323107} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CBS 2105 {ECO:0000313|Proteomes:UP000323107}; RA Ortiz-Merino R.A., Braun-Galleani S., Wolfe K.H., Morrissey J.P.; RT "Kluyveromyces lactis var. drosophilarum CBS 2105 Genome assembly."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=acetyl-CoA + H2O = acetate + CoA + H(+); Xref=Rhea:RHEA:20289, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=3.1.2.1; CC Evidence={ECO:0000256|ARBA:ARBA00001831}; CC -!- SIMILARITY: Belongs to the acetyl-CoA hydrolase/transferase family. CC {ECO:0000256|ARBA:ARBA00009632}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP042460; QEU62654.1; -; Genomic_DNA. DR VEuPathDB; FungiDB:KLLA0_E10561g; -. DR Proteomes; UP000323107; Chromosome 6. DR GO; GO:0008775; F:acetate CoA-transferase activity; IEA:InterPro. DR GO; GO:0003986; F:acetyl-CoA hydrolase activity; IEA:UniProtKB-EC. DR GO; GO:0006083; P:acetate metabolic process; IEA:InterPro. DR GO; GO:0019679; P:propionate metabolic process, methylcitrate cycle; IEA:InterPro. DR Gene3D; 3.40.1080.20; -; 1. DR InterPro; IPR026888; AcetylCoA_hyd_C. DR InterPro; IPR038460; AcetylCoA_hyd_C_sf. DR InterPro; IPR003702; ActCoA_hydro. DR InterPro; IPR037171; NagB/RpiA_transferase-like. DR Pfam; PF13336; AcetylCoA_hyd_C; 1. DR Pfam; PF02550; AcetylCoA_hydro; 1. DR SUPFAM; SSF100950; SSF100950; 2. PE 3: Inferred from homology; FT DOMAIN 331..481 FT /note="AcetylCoA_hyd_C" FT /evidence="ECO:0000259|Pfam:PF13336" SQ SEQUENCE 523 AA; 58295 MW; E83305E56C39331E CRC64; MTVSRLLKDR VRYAPYLKKV KPVEELIPLF KDGQYIGWSG FTGVGAPKAV PEALIKHVEE NNLQGKLRFN LFVGASAGPE ECKWAEHDMI LRRAPHQVGK PIAKAINDGR IQFFDKHLSM FPQDLTYGYY SRNRTDGKIL DYTIIEATAI KEDGSIVPGP SVGGSPEFIS VSDKIIIEVN TATPSFEGLH DIDMPVNPPF RQPYPYTTVD QKNGLDSIPV DPERVVAVVE STQRDVVGPN TPSDATSQSI ARHLVEFFEN EVRHGRLPEN LHPLQSGIGN IANAVIEGLT DSSFKNLTVW TEVLQDSFLD LFENGALDYA TATSIRLTEA GFQKFFDNWD DFSKKLCLRS QVVSNNPELI RRLGVIAMNT PVEVDIYAHA NSTNVSGSRM LNGLGGSADF LRNAKLSIMH APAARPTKTD PTGISTIVPM ASHVDQTEHD LDVLVTDQGL ADLRGLSPRE RAREIIKNCA HPDYQPILTD YLDRSEHYAK LHKCMHEPHM LKNAFKFHLN LSEKGTMKVD NWD //