ID A0A5N4DYL7_CAMDR Unreviewed; 283 AA. AC A0A5N4DYL7; DT 26-FEB-2020, integrated into UniProtKB/TrEMBL. DT 26-FEB-2020, sequence version 1. DT 07-OCT-2020, entry version 5. DE RecName: Full=Insulin-induced gene protein {ECO:0000256|RuleBase:RU241113}; GN ORFNames=Cadr_000008708 {ECO:0000313|EMBL:KAB1276165.1}; OS Camelus dromedarius (Dromedary) (Arabian camel). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus. OX NCBI_TaxID=9838 {ECO:0000313|EMBL:KAB1276165.1, ECO:0000313|Proteomes:UP000299084}; RN [1] {ECO:0000313|EMBL:KAB1276165.1, ECO:0000313|Proteomes:UP000299084} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Drom800 {ECO:0000313|EMBL:KAB1276165.1}; RC TISSUE=Blood {ECO:0000313|EMBL:KAB1276165.1}; RX PubMed=30972949; DOI=.1111/1755-0998.13020; RA Elbers J.P., Rogers M.F., Perelman P.L., Proskuryakova A.A., RA Serdyukova N.A., Johnson W.E., Horin P., Corander J., Murphy D., RA Burger P.A.; RT "Improving Illumina assemblies with Hi-C and long reads: an example with RT the North African dromedary."; RL Mol. Ecol. Resour. 19:1015-1026(2019). CC -!- FUNCTION: Mediates feedback control of cholesterol synthesis. CC {ECO:0000256|RuleBase:RU241113}. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU241113}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477, CC ECO:0000256|RuleBase:RU241113}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the INSIG family. CC {ECO:0000256|ARBA:ARBA00007475, ECO:0000256|RuleBase:RU241113}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:KAB1276165.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JWIN03000007; KAB1276165.1; -; Genomic_DNA. DR Proteomes; UP000299084; Chromosome 7. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW. DR InterPro; IPR009904; INSIG-1. DR InterPro; IPR025929; INSIG_fam. DR PANTHER; PTHR15301; PTHR15301; 1. DR PANTHER; PTHR15301:SF11; PTHR15301:SF11; 1. DR Pfam; PF07281; INSIG; 1. PE 3: Inferred from homology; KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548, KW ECO:0000256|RuleBase:RU241113}; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824, KW ECO:0000256|RuleBase:RU241113}; KW Lipid metabolism {ECO:0000256|RuleBase:RU241113}; KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU241113}; KW Reference proteome {ECO:0000313|Proteomes:UP000299084}; KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221, KW ECO:0000256|RuleBase:RU241113}; KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU241113}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 81..99 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 119..139 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 175..196 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 203..222 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 258..279 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" SQ SEQUENCE 283 AA; 30594 MW; B9727404666382BF CRC64; MPRLDDHLWS CPCAKGVKHR SHLRTGAGGL EAKVGEMTTS SVSGPSLLVA HGAGGTDPAP GPQSSGLGGH SWHHHLLQRS LVLFSVGVVL ALVLNLLQVQ RNVTLFPEEV IATIFSSAWW VPPCCGTAAA VVGLLYPCID SRLGEPHKFK REWASVMRCV AVFVGINHAS AKLDFANNVQ LSLTLAALSL GLWWTFDRSR SGLGLGITIA FLATLITQLL VYNGVYQYTS PDFLYIRSWL PCIFFSGGVT VGNIGRQLAM VCEVVAFALT LVFSLRRLLY IAH //