ID A0A5N4AC92_PHOPY Unreviewed; 1087 AA. AC A0A5N4AC92; DT 26-FEB-2020, integrated into UniProtKB/TrEMBL. DT 26-FEB-2020, sequence version 1. DT 12-AUG-2020, entry version 4. DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551}; DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551}; GN ORFNames=PPYR_11773 {ECO:0000313|EMBL:KAB0794934.1}; OS Photinus pyralis (Common eastern firefly) (Lampyris pyralis). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Holometabola; Coleoptera; Polyphaga; Elateriformia; Elateroidea; OC Lampyridae; Lampyrinae; Photinus. OX NCBI_TaxID=7054 {ECO:0000313|EMBL:KAB0794934.1, ECO:0000313|Proteomes:UP000327044}; RN [1] {ECO:0000313|EMBL:KAB0794934.1, ECO:0000313|Proteomes:UP000327044} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=1611_PpyrPB1 {ECO:0000313|EMBL:KAB0794934.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:KAB0794934.1}; RX PubMed=30324905; RA Fallon T.R., Lower S.E., Chang C.H., Bessho-Uehara M., Martin G.J., RA Bewick A.J., Behringer M., Debat H.J., Wong I., Day J.C., Suvorov A., RA Silva C.J., Stanger-Hall K.F., Hall D.W., Schmitz R.J., Nelson D.R., RA Lewis S.M., Shigenobu S., Bybee S.M., Larracuente A.M., Oba Y., Weng J.K.; RT "Firefly genomes illuminate parallel origins of bioluminescence in RT beetles."; RL Elife 7:e36495-e36495(2018). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; CC Evidence={ECO:0000256|ARBA:ARBA00001665}; CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily. CC {ECO:0000256|ARBA:ARBA00005446}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:KAB0794934.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; VVIM01000008; KAB0794934.1; -; Genomic_DNA. DR Proteomes; UP000327044; Unassembled WGS sequence. DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro. DR GO; GO:0006310; P:DNA recombination; IEA:InterPro. DR GO; GO:0006281; P:DNA repair; IEA:InterPro. DR GO; GO:0006260; P:DNA replication; IEA:InterPro. DR Gene3D; 1.10.10.10; -; 1. DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom. DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ. DR InterPro; IPR014001; Helicase_ATP-bd. DR InterPro; IPR001650; Helicase_C. DR InterPro; IPR029491; Helicase_HTH. DR InterPro; IPR010997; HRDC-like_sf. DR InterPro; IPR002121; HRDC_dom. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR032284; RecQ_Zn-bd. DR InterPro; IPR018982; RQC_domain. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00270; DEAD; 1. DR Pfam; PF00271; Helicase_C; 1. DR Pfam; PF00570; HRDC; 1. DR Pfam; PF14493; HTH_40; 1. DR Pfam; PF16124; RecQ_Zn_bind; 1. DR Pfam; PF09382; RQC; 1. DR SMART; SM00487; DEXDc; 1. DR SMART; SM00490; HELICc; 1. DR SMART; SM00341; HRDC; 1. DR SMART; SM00956; RQC; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF47819; SSF47819; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR TIGRFAMs; TIGR00614; recQ_fam; 1. DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1. DR PROSITE; PS51194; HELICASE_CTER; 1. DR PROSITE; PS50967; HRDC; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW Helicase {ECO:0000256|ARBA:ARBA00022806}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022806}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Reference proteome {ECO:0000313|Proteomes:UP000327044}. FT DOMAIN 74..244 FT /note="Helicase ATP-binding" FT /evidence="ECO:0000259|PROSITE:PS51192" FT DOMAIN 269..419 FT /note="Helicase C-terminal" FT /evidence="ECO:0000259|PROSITE:PS51194" FT DOMAIN 661..743 FT /note="HRDC" FT /evidence="ECO:0000259|PROSITE:PS50967" FT REGION 919..975 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 941..964 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1087 AA; 122045 MW; 9EDAFE7BCDD81D88 CRC64; MSVLDYECLF NEFQENDEWD ECFNAVDKCD VEQELIAKSN AVNDEERPQK EYLEVLQRVF GHKSFRPMQW KIISSIINDR RDNCSIMATG YGKSLCFQYP SVYLGGVTII ISPLISLMED QVLSMKMSNI SACLLGSAQT KQKEVIDEIF EEKYNLVYMT PEFSCGDYGQ GLIKRIDDAV SLILIAIDEA HCVSSWGHDF RYQYRELGKL RDLLPTVPIL AVTATATHQV RGDIISTLKL RNPQILCSGF DRPNLQFIVY IKGNGLMSDL KKVMIEKNNS WSLPGSTIIY CITRKQTEDI ANQVNSIKGM KCLAYHAGMS VKQRSQAHEQ FAKDKIKIIV ATIAFGMGID KPDVRNIIHY GASKDLESYY QEVGRAGRDG LPSKCITFYN SADFDMHHAI REMHGSHTSA QNSQRRDMME KIMRQYLETR DCRRQFILNH FEGSVTLKGP SKNCCDNCTR KLSSSLSDHN KYEGLNEKGL YDFAPETRMF LEAVEVMGGK FGFGMYALFI RGSKSTRLYQ RYHGHSLHGC GKHQTEDWWK AIGKLIDREG YLEKRRPPKA GKRAFNASTY GISAKGEAFL RSPKSTQILL QPTPEIFNLL KLKHQPEFSE EDFFKSSQPV ASTSVTSTKS APSFKSKISL QLMKPAKSVD SIEESTEIVP SEECMKLYNE LMAKREEIAT ASECMPYMVA SNEALMKMAE KKPVTIKDLR KCRLVGFTEA KINRFGEEFI KTIRSACHLE SLDTTDNVKK PIEEILAKHP LPGHKIGATA QVSYSMYKSG LTVQEIATKR GVLPQVILSH LIDGIKVGYP IQMIDLNVTD DMRHTILTAI KNTLPEVGNG SLSVIKNACP PEISMDALRV VVAYQQVRTH LSKLNIPYEE FESSLEDIGQ LDMTSVSDTS MSSTPKAKLN FSSLYKKSDK RCADSDGSTD VGSGSTSEID NQRIKKQRLT ESPAAKKDDL TFLDSPPRSS HSLSDTIVKR EVADVNPCSS QADVKSCNVS SSLLDDDFFD DQLLENVDKV VALSPTVSQN GQHKVVNALS QQEKCQSQPL LDCTTTSKSN LTKKFNFKSM VPKSVTEKAQ QLCSKQP //