ID A0A5J6WGC2_HUMAN Unreviewed; 274 AA. AC A0A5J6WGC2; DT 11-DEC-2019, integrated into UniProtKB/TrEMBL. DT 11-DEC-2019, sequence version 1. DT 08-NOV-2023, entry version 10. DE SubName: Full=Glycosyltransferase B {ECO:0000313|EMBL:QFI36308.1}; DE Flags: Fragment; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:QFI36308.1}; RN [1] {ECO:0000313|EMBL:QFI36308.1} RP NUCLEOTIDE SEQUENCE. RA Zuo Q., Xu H., Wu D., Chu X., Mao J., Wang H., Zhang W.; RT "A weak expressing B antigen caused by a novel allele of alpha 1-3- RT galactosyltransferase."; RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases. CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|PIRSR:PIRSR605076-3}; CC Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR605076-3}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single- CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}. CC -!- SIMILARITY: Belongs to the glycosyltransferase 6 family. CC {ECO:0000256|ARBA:ARBA00010413}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MK703802; QFI36308.1; -; Genomic_DNA. DR AlphaFoldDB; A0A5J6WGC2; -. DR PeptideAtlas; A0A5J6WGC2; -. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016758; F:hexosyltransferase activity; IEA:InterPro. DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro. DR CDD; cd02515; Glyco_transf_6; 1. DR InterPro; IPR005076; Glyco_trans_6. DR InterPro; IPR029044; Nucleotide-diphossugar_trans. DR PANTHER; PTHR10462; GLYCOSYLTRANSFERASE-RELATED; 1. DR PANTHER; PTHR10462:SF29; HISTO-BLOOD GROUP ABO SYSTEM TRANSFERASE; 1. DR Pfam; PF03414; Glyco_transf_6; 1. DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1. PE 3: Inferred from homology; KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676}; KW Manganese {ECO:0000256|PIRSR:PIRSR605076-3}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR605076-3}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:QFI36308.1}. FT ACT_SITE 223 FT /note="Nucleophile" FT /evidence="ECO:0000256|PIRSR:PIRSR605076-1" FT BINDING 41..43 FT /ligand="UDP-N-acetyl-alpha-D-galactosamine" FT /ligand_id="ChEBI:CHEBI:67138" FT /evidence="ECO:0000256|PIRSR:PIRSR605076-2" FT BINDING 46 FT /ligand="UDP-N-acetyl-alpha-D-galactosamine" FT /ligand_id="ChEBI:CHEBI:67138" FT /evidence="ECO:0000256|PIRSR:PIRSR605076-2" FT BINDING 131..133 FT /ligand="UDP-N-acetyl-alpha-D-galactosamine" FT /ligand_id="ChEBI:CHEBI:67138" FT /evidence="ECO:0000256|PIRSR:PIRSR605076-2" FT BINDING 131 FT /ligand="Mn(2+)" FT /ligand_id="ChEBI:CHEBI:29035" FT /evidence="ECO:0000256|PIRSR:PIRSR605076-3" FT BINDING 133 FT /ligand="Mn(2+)" FT /ligand_id="ChEBI:CHEBI:29035" FT /evidence="ECO:0000256|PIRSR:PIRSR605076-3" FT BINDING 153 FT /ligand="an alpha-L-fucosyl-(1->2)-beta-D-galactosyl FT derivative" FT /ligand_id="ChEBI:CHEBI:140327" FT /evidence="ECO:0000256|PIRSR:PIRSR605076-2" FT BINDING 165 FT /ligand="an alpha-L-fucosyl-(1->2)-beta-D-galactosyl FT derivative" FT /ligand_id="ChEBI:CHEBI:140327" FT /evidence="ECO:0000256|PIRSR:PIRSR605076-2" FT BINDING 223 FT /ligand="an alpha-L-fucosyl-(1->2)-beta-D-galactosyl FT derivative" FT /ligand_id="ChEBI:CHEBI:140327" FT /evidence="ECO:0000256|PIRSR:PIRSR605076-2" FT BINDING 246 FT /ligand="an alpha-L-fucosyl-(1->2)-beta-D-galactosyl FT derivative" FT /ligand_id="ChEBI:CHEBI:140327" FT /evidence="ECO:0000256|PIRSR:PIRSR605076-2" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:QFI36308.1" SQ SEQUENCE 274 AA; 31923 MW; 35E92CEA3E31FA7C CRC64; RKDVLVVTPW LAPIVWEGTF NIDILNEQFR LQNTTIGLTV FAIKKYVAFL KLFLETAEKH FMVGHRVHYY VFTDQPAAVP RVTLGTGRQL SVLEVGAYKR WQDVSMRRME MISDFCERRF LSEVDYLVCV DVDMEFRDHV GVEILTPLFG TLHPSFYGSS REAFTYERRP QSQAYIPKDE GDFYYMGAFF GGSVQEVQRL TRACHQAMMV DQANGIKAVW HDESHLNKYL LRHKPTKVLS PEYLWDQQLL GWPAVLRKLR FTAVPKNHQA VRNP //