ID A0A5H7MQK7_SALET Unreviewed; 140 AA. AC A0A5H7MQK7; DT 11-DEC-2019, integrated into UniProtKB/TrEMBL. DT 11-DEC-2019, sequence version 1. DT 07-OCT-2020, entry version 6. DE RecName: Full=L-fucose mutarotase {ECO:0000256|HAMAP-Rule:MF_01662}; DE EC=5.1.3.29 {ECO:0000256|HAMAP-Rule:MF_01662}; DE AltName: Full=Fucose 1-epimerase {ECO:0000256|HAMAP-Rule:MF_01662}; DE AltName: Full=Type-2 mutarotase {ECO:0000256|HAMAP-Rule:MF_01662}; GN Name=fucU {ECO:0000256|HAMAP-Rule:MF_01662, GN ECO:0000313|EMBL:ECF3834285.1}; GN ORFNames=A0E74_16065 {ECO:0000313|EMBL:ECT5570005.1}, BFV08_15365 GN {ECO:0000313|EMBL:ECT7928762.1}, DM677_03350 GN {ECO:0000313|EMBL:EBU9892211.1}, DPE57_04560 GN {ECO:0000313|EMBL:EBS3931185.1}, DQK10_18560 GN {ECO:0000313|EMBL:MLO06652.1}, DWU42_03005 GN {ECO:0000313|EMBL:ECT1798524.1}, E1821_15960 GN {ECO:0000313|EMBL:ECG8286419.1}, E1B31_15750 GN {ECO:0000313|EMBL:ECD4764268.1}, E4A02_12260 GN {ECO:0000313|EMBL:ECF3834285.1}, EUR83_05780 GN {ECO:0000313|EMBL:ECB0311916.1}, EWC91_05760 GN {ECO:0000313|EMBL:ECG2741998.1}, EWG08_15155 GN {ECO:0000313|EMBL:ECE8817793.1}, EWZ30_00780 GN {ECO:0000313|EMBL:ECD2223580.1}, EZX42_16590 GN {ECO:0000313|EMBL:ECD3427178.1}; OS Salmonella enterica subsp. enterica serovar Reading. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Salmonella. OX NCBI_TaxID=165302 {ECO:0000313|EMBL:ECD4764268.1}; RN [1] {ECO:0000313|EMBL:ECT7928762.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PNUSAS003387 {ECO:0000313|EMBL:ECT7928762.1}; RG PulseNet: The National Subtyping Network for Foodborne Disease Surveillance; RA Tarr C.L., Trees E., Katz L.S., Carleton-Romer H.A., Stroika S., RA Kucerova Z., Roache K.F., Sabol A.L., Besser J., Gerner-Smidt P.; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ECT1798524.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=FSIS11812185 {ECO:0000313|EMBL:ECT1798524.1}; RG GenomeTrakr network: Whole genome sequencing for foodborne pathogen traceback; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:ECT5570005.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=FSIS1605767 {ECO:0000313|EMBL:ECT5570005.1}; RG NARMS: The National Antimicrobial Resistance Monitoring System; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:ECD4764268.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=146074 {ECO:0000313|EMBL:EBS3931185.1}, 186573 RC {ECO:0000313|EMBL:ECG8286419.1}, 261481 RC {ECO:0000313|EMBL:ECD4764268.1}, 275776 {ECO:0000313|EMBL:MLO06652.1, RC ECO:0000313|Proteomes:UP000277002}, 298956 RC {ECO:0000313|EMBL:EBU9892211.1}, 413193 RC {ECO:0000313|EMBL:ECD2223580.1}, 442158 RC {ECO:0000313|EMBL:ECE8817793.1}, 458062 RC {ECO:0000313|EMBL:ECG2741998.1}, 654694 RC {ECO:0000313|EMBL:ECB0311916.1}, 690336 RC {ECO:0000313|EMBL:ECD3427178.1}, and 708215 RC {ECO:0000313|EMBL:ECF3834285.1}; RA Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.; RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the anomeric conversion of L-fucose. CC {ECO:0000256|HAMAP-Rule:MF_01662}. CC -!- CATALYTIC ACTIVITY: CC Reaction=alpha-L-fucose = beta-L-fucose; Xref=Rhea:RHEA:25580, CC ChEBI:CHEBI:42548, ChEBI:CHEBI:42589; EC=5.1.3.29; CC Evidence={ECO:0000256|HAMAP-Rule:MF_01662}; CC -!- CATALYTIC ACTIVITY: CC Reaction=beta-D-ribopyranose = beta-D-ribofuranose; CC Xref=Rhea:RHEA:25432, ChEBI:CHEBI:27476, ChEBI:CHEBI:47002; CC EC=5.4.99.62; Evidence={ECO:0000256|ARBA:ARBA00000223}; CC -!- PATHWAY: Carbohydrate metabolism; L-fucose metabolism. CC {ECO:0000256|HAMAP-Rule:MF_01662}. CC -!- SUBUNIT: Homodecamer. {ECO:0000256|HAMAP-Rule:MF_01662}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01662}. CC -!- SIMILARITY: Belongs to the RbsD / FucU family. FucU mutarotase CC subfamily. {ECO:0000256|HAMAP-Rule:MF_01662}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:ECD4764268.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAGVGK010000003; EBS3931185.1; -; Genomic_DNA. DR EMBL; AAHDUY010000002; EBU9892211.1; -; Genomic_DNA. DR EMBL; AAHWGP010000003; ECB0311916.1; -; Genomic_DNA. DR EMBL; AAIEAE010000001; ECD2223580.1; -; Genomic_DNA. DR EMBL; AAIEKD010000012; ECD3427178.1; -; Genomic_DNA. DR EMBL; AAIEVF010000013; ECD4764268.1; -; Genomic_DNA. DR EMBL; AAIJJT010000021; ECE8817793.1; -; Genomic_DNA. DR EMBL; AAIKZN010000008; ECF3834285.1; -; Genomic_DNA. DR EMBL; AAINVR010000004; ECG2741998.1; -; Genomic_DNA. DR EMBL; AAIOXY010000011; ECG8286419.1; -; Genomic_DNA. DR EMBL; AAKLYL010000006; ECT1798524.1; -; Genomic_DNA. DR EMBL; AAKNDM010000016; ECT5570005.1; -; Genomic_DNA. DR EMBL; AAKNWZ010000005; ECT7928762.1; -; Genomic_DNA. DR EMBL; RVCL01000012; MLO06652.1; -; Genomic_DNA. DR RefSeq; WP_000920848.1; NZ_MZFM01000013.1. DR SMR; A0A5H7MQK7; -. DR UniPathway; UPA00956; -. DR Proteomes; UP000277002; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0062193; F:D-ribose pyranase activity; IEA:UniProtKB-EC. DR GO; GO:0042806; F:fucose binding; IEA:InterPro. DR GO; GO:0036373; F:L-fucose mutarotase activity; IEA:UniProtKB-EC. DR GO; GO:0042354; P:L-fucose metabolic process; IEA:UniProtKB-UniRule. DR Gene3D; 3.40.1650.10; -; 1. DR HAMAP; MF_01662; L_fucose_rotase; 1. DR InterPro; IPR023751; L-fucose_mutarotase. DR InterPro; IPR023750; RbsD-like_sf. DR InterPro; IPR007721; RbsD_FucU. DR Pfam; PF05025; RbsD_FucU; 1. DR SUPFAM; SSF102546; SSF102546; 1. PE 3: Inferred from homology; KW Carbohydrate metabolism {ECO:0000256|HAMAP-Rule:MF_01662}; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01662}; KW Fucose metabolism {ECO:0000256|ARBA:ARBA00023253, ECO:0000256|HAMAP- KW Rule:MF_01662}; KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|HAMAP-Rule:MF_01662, KW ECO:0000313|EMBL:ECD4764268.1}. FT REGION 129..131 FT /note="Substrate binding" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01662" FT ACT_SITE 22 FT /note="Proton donor" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01662" FT BINDING 30 FT /note="Substrate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01662" FT BINDING 107 FT /note="Substrate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01662" SQ SEQUENCE 140 AA; 15254 MW; F80F469B5DC2F30D CRC64; MLKTISPLIS PTLLKVLAEM GHGDEIIFSD AHFPAHSLGP QVIRADGLSV SDLLRAIIPL FELDSYAPPL VMMAAVEGDT LDPSVEARYR DALSLEAPCP DIVRIDRYAF YERAQKAFAI VITGECAKYG NILLKKGVTP //