ID A0A5H7MQK7_SALET Unreviewed; 140 AA. AC A0A5H7MQK7; DT 11-DEC-2019, integrated into UniProtKB/TrEMBL. DT 11-DEC-2019, sequence version 1. DT 29-SEP-2021, entry version 11. DE RecName: Full=L-fucose mutarotase {ECO:0000256|HAMAP-Rule:MF_01662}; DE EC=5.1.3.29 {ECO:0000256|HAMAP-Rule:MF_01662}; DE AltName: Full=Fucose 1-epimerase {ECO:0000256|HAMAP-Rule:MF_01662}; DE AltName: Full=Type-2 mutarotase {ECO:0000256|HAMAP-Rule:MF_01662}; GN Name=fucU {ECO:0000256|HAMAP-Rule:MF_01662, GN ECO:0000313|EMBL:HAE8736580.1}; GN ORFNames=BFV08_15365 {ECO:0000313|EMBL:ECT7928762.1}, DM677_03350 GN {ECO:0000313|EMBL:EBU9892211.1}, DPE57_04560 GN {ECO:0000313|EMBL:EBS3931185.1}, DQK10_18560 GN {ECO:0000313|EMBL:MLO06652.1}, EJO80_04575 GN {ECO:0000313|EMBL:QRA27751.1}, G4R07_001704 GN {ECO:0000313|EMBL:HAE8736580.1}; OS Salmonella enterica subsp. enterica serovar Reading. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Salmonella. OX NCBI_TaxID=165302 {ECO:0000313|EMBL:ECT7928762.1}; RN [1] {ECO:0000313|EMBL:HAE8736580.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=M210 {ECO:0000313|EMBL:HAE8736580.1}; RX PubMed=30286803; RA Souvorov A., Agarwala R., Lipman D.J.; RT "SKESA: strategic k-mer extension for scrupulous assemblies."; RL Genome Biol. 19:153-150(2018). RN [2] {ECO:0000313|EMBL:EBS3931185.1, ECO:0000313|Proteomes:UP000277002} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=146074 {ECO:0000313|EMBL:EBS3931185.1}, 275776 RC {ECO:0000313|EMBL:MLO06652.1, ECO:0000313|Proteomes:UP000277002}, and RC 298956 {ECO:0000313|EMBL:EBU9892211.1}; RA Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:ECT7928762.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PNUSAS003387 {ECO:0000313|EMBL:ECT7928762.1}; RG PulseNet: The National Subtyping Network for Foodborne Disease Surveillance; RA Tarr C.L., Trees E., Katz L.S., Carleton-Romer H.A., Stroika S., RA Kucerova Z., Roache K.F., Sabol A.L., Besser J., Gerner-Smidt P.; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:HAE8736580.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=M210 {ECO:0000313|EMBL:HAE8736580.1}; RG NCBI Pathogen Detection Project; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:QRA27751.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CFSAN080607 {ECO:0000313|EMBL:QRA27751.1}; RA Hoffmann M., Balkey M., Timme R., Pirone C.; RT "Whole genome sequencing of cultured pathogen."; RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the anomeric conversion of L-fucose. CC {ECO:0000256|HAMAP-Rule:MF_01662}. CC -!- CATALYTIC ACTIVITY: CC Reaction=alpha-L-fucose = beta-L-fucose; Xref=Rhea:RHEA:25580, CC ChEBI:CHEBI:42548, ChEBI:CHEBI:42589; EC=5.1.3.29; CC Evidence={ECO:0000256|HAMAP-Rule:MF_01662}; CC -!- CATALYTIC ACTIVITY: CC Reaction=beta-D-ribopyranose = beta-D-ribofuranose; CC Xref=Rhea:RHEA:25432, ChEBI:CHEBI:27476, ChEBI:CHEBI:47002; CC EC=5.4.99.62; Evidence={ECO:0000256|ARBA:ARBA00000223}; CC -!- PATHWAY: Carbohydrate metabolism; L-fucose metabolism. CC {ECO:0000256|HAMAP-Rule:MF_01662}. CC -!- SUBUNIT: Homodecamer. {ECO:0000256|HAMAP-Rule:MF_01662}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01662}. CC -!- SIMILARITY: Belongs to the RbsD / FucU family. FucU mutarotase CC subfamily. {ECO:0000256|HAMAP-Rule:MF_01662}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAGVGK010000003; EBS3931185.1; -; Genomic_DNA. DR EMBL; AAHDUY010000002; EBU9892211.1; -; Genomic_DNA. DR EMBL; AAKNWZ010000005; ECT7928762.1; -; Genomic_DNA. DR EMBL; DAATIJ010000003; HAE8736580.1; -; Genomic_DNA. DR EMBL; RVCL01000012; MLO06652.1; -; Genomic_DNA. DR EMBL; CP068783; QRA27751.1; -; Genomic_DNA. DR RefSeq; WP_000920848.1; NZ_MZFM01000013.1. DR UniPathway; UPA00956; -. DR Proteomes; UP000277002; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0062193; F:D-ribose pyranase activity; IEA:UniProtKB-EC. DR GO; GO:0042806; F:fucose binding; IEA:InterPro. DR GO; GO:0036373; F:L-fucose mutarotase activity; IEA:UniProtKB-EC. DR GO; GO:0042354; P:L-fucose metabolic process; IEA:UniProtKB-UniRule. DR Gene3D; 3.40.1650.10; -; 1. DR HAMAP; MF_01662; L_fucose_rotase; 1. DR InterPro; IPR023751; L-fucose_mutarotase. DR InterPro; IPR023750; RbsD-like_sf. DR InterPro; IPR007721; RbsD_FucU. DR Pfam; PF05025; RbsD_FucU; 1. DR SUPFAM; SSF102546; SSF102546; 1. PE 3: Inferred from homology; KW Carbohydrate metabolism {ECO:0000256|HAMAP-Rule:MF_01662}; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01662}; KW Fucose metabolism {ECO:0000256|ARBA:ARBA00023253, ECO:0000256|HAMAP- KW Rule:MF_01662}; KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|HAMAP-Rule:MF_01662}. FT REGION 129..131 FT /note="Substrate binding" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01662" FT ACT_SITE 22 FT /note="Proton donor" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01662" FT BINDING 30 FT /note="Substrate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01662" FT BINDING 107 FT /note="Substrate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01662" SQ SEQUENCE 140 AA; 15254 MW; F80F469B5DC2F30D CRC64; MLKTISPLIS PTLLKVLAEM GHGDEIIFSD AHFPAHSLGP QVIRADGLSV SDLLRAIIPL FELDSYAPPL VMMAAVEGDT LDPSVEARYR DALSLEAPCP DIVRIDRYAF YERAQKAFAI VITGECAKYG NILLKKGVTP //