ID A0A5H2WW55_MACHE Unreviewed; 333 AA. AC A0A5H2WW55; DT 11-DEC-2019, integrated into UniProtKB/TrEMBL. DT 11-DEC-2019, sequence version 1. DT 29-MAY-2024, entry version 17. DE RecName: Full=Taste receptor type 2 {ECO:0000256|RuleBase:RU004424}; GN Name=TAS2R38 {ECO:0000313|EMBL:BBJ32819.1}; OS Macaca hecki (Heck's macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; OC Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=90382 {ECO:0000313|EMBL:BBJ32819.1}; RN [1] {ECO:0000313|EMBL:BBJ32819.1} RP NUCLEOTIDE SEQUENCE. RA Widayati K.A., Yan X., Suzuki-Hashido N., Itoigawa A., Purba L.H.P.S., RA Fahri F., Terai Y., Suryobroto B., Imai H.; RT "Functional divergence of the bitter receptor TAS2R38 in Sulawesi RT macaques."; RL Ecol. Evol. 0:0-0(2019). CC -!- FUNCTION: Receptor that may play a role in the perception of bitterness CC and is gustducin-linked. May play a role in sensing the chemical CC composition of the gastrointestinal content. The activity of this CC receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation CC and lead to the gating of TRPM5. {ECO:0000256|ARBA:ARBA00024847}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141, CC ECO:0000256|RuleBase:RU004424}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004424}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family. CC {ECO:0000256|ARBA:ARBA00007376, ECO:0000256|RuleBase:RU004423}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LC473456; BBJ32819.1; -; Genomic_DNA. DR AlphaFoldDB; A0A5H2WW55; -. DR GO; GO:0005886; C:plasma membrane; IEA:UniProt. DR GO; GO:0033038; F:bitter taste receptor activity; IEA:InterPro. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR CDD; cd15025; 7tm_TAS2R38; 1. DR InterPro; IPR007960; TAS2R. DR InterPro; IPR030050; TAS2R38. DR PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1. DR PANTHER; PTHR11394:SF52; TASTE RECEPTOR TYPE 2 MEMBER 38; 1. DR Pfam; PF05296; TAS2R; 1. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. PE 3: Inferred from homology; KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040, KW ECO:0000256|RuleBase:RU004424}; KW Membrane {ECO:0000256|RuleBase:RU004424, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004424}; KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606, KW ECO:0000256|RuleBase:RU004424}; KW Taste {ECO:0000256|ARBA:ARBA00022480, ECO:0000256|RuleBase:RU004424}; KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU004424}; KW Transmembrane {ECO:0000256|RuleBase:RU004424, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 20..43 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 55..76 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 96..118 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 144..168 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 191..218 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 249..271 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 277..298 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" SQ SEQUENCE 333 AA; 37648 MW; A6EE4C88AD67B628 CRC64; MLTLTHICTV SSEVRSTFLF ISVLEFAVGF LTNAFISLVN FWDVVKRQPL SNSDCVLLCL SISRLFLHGL LFLSAIQLTH FQKLSEPLNH SYQAILMLWM IANQANLWLA ACLSLLYCSK LIRFSHTFLI CLANWVSRKI SQMLLGIILC SCICTVLCVW CFFGRLHFTV TTVLFMNNNT RLNWQIKDLN LFYSFLFCYL WSVPPFLLFL VSSGMLTVSL GRHMRTMKVY TRDSRDPSLE AHIKALKSLI SFFCFFAISS CAAFISVPLL ILWHDKIGVM VCVGIMAACP SGHAAVLISG NAKLRRAVTT ILLWAQSSLK VRADHMADSR TPC //