ID A0A5F9ZHE0_HUMAN Unreviewed; 486 AA. AC A0A5F9ZHE0; DT 11-DEC-2019, integrated into UniProtKB/TrEMBL. DT 11-DEC-2019, sequence version 1. DT 22-APR-2020, entry version 3. DE RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007}; DE EC=2.7.1.- {ECO:0000256|RuleBase:RU362007}; GN Name=GCK {ECO:0000313|Ensembl:ENSP00000500264}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000500264, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000500264, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., RA Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000500264} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2019) to UniProtKB. CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- CC phosphate and glycerone phosphate from D-glucose: step 1/4. CC {ECO:0000256|SAAS:SAAS01216704}. CC -!- SIMILARITY: Belongs to the hexokinase family. CC {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00672880}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC006454; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458452; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000671824; ENSP00000500264; ENSG00000106633. DR HGNC; HGNC:4195; GCK. DR OpenTargets; ENSG00000106633; -. DR GeneTree; ENSGT00950000182787; -. DR UniPathway; UPA00109; UER00180. DR Proteomes; UP000005640; Chromosome 7. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-UniRule. DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway. DR InterPro; IPR039073; GCK_chordate. DR InterPro; IPR001312; Hexokinase. DR InterPro; IPR019807; Hexokinase_BS. DR InterPro; IPR022673; Hexokinase_C. DR InterPro; IPR022672; Hexokinase_N. DR PANTHER; PTHR19443; PTHR19443; 2. DR PANTHER; PTHR19443:SF3; PTHR19443:SF3; 2. DR Pfam; PF00349; Hexokinase_1; 1. DR Pfam; PF03727; Hexokinase_2; 1. DR PROSITE; PS00378; HEXOKINASE_1; 1. DR PROSITE; PS51748; HEXOKINASE_2; 1. PE 1: Evidence at protein level; KW ATP-binding {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00216502}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Glycolysis {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00216492}; KW Kinase {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00216507}; KW Nucleotide-binding {ECO:0000256|RuleBase:RU362007, KW ECO:0000256|SAAS:SAAS00672883}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A5F9ZHE0, KW ECO:0000213|ProteomicsDB:A0A5F9ZHE0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transferase {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00672884}. FT DOMAIN 16..215 FT /note="Hexokinase_1" FT /evidence="ECO:0000259|Pfam:PF00349" FT DOMAIN 221..476 FT /note="Hexokinase_2" FT /evidence="ECO:0000259|Pfam:PF03727" FT COILED 13..40 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 486 AA; 54386 MW; CCC0D74620A62C27 CRC64; MLDDRARMEA AKKEKVEQIL AEFQLQEEDL KKVMRRMQKE MDRGLRLETH EEASVKMLPT YVRSTPEGSE VGDFLSLDLG GTNFRVMLVK VGEGEEGQWS VKTKHQMYSI PEDAMTGTAE MLFDYISECI SDFLDKHQMK HKKLPLGFTF SFPVRHEDID KGILLNWTKG FKASGAEGNN VVGLLRDAIK RRGDFEMDVV AMVNDTVATM ISCYYEDHQC EVGMIVGTGC NACYMEEMQN VELVEGDEGR MCVNTEWGAF GDSGELDEFL LEYDRLVDES SANPGDRACR GGSETPPARF LGLTQHSPKY EKLIGGKYMG ELVRLVLLRL VDENLLFHGE ASEQLRTRGA FETRFVSQVE SDTGDRKQIY NILSTLGLRP STTDCDIVRR ACESVSTRAA HMCSAGLAGV INRMRESRSE DVMRITVGVD GSVYKLHPSF KERFHASVRR LTPSCEITFI ESEEGSGRGA ALVSAVACKK ACMLGQ //