ID A0A5F9CT06_RABIT Unreviewed; 342 AA. AC A0A5F9CT06; DT 11-DEC-2019, integrated into UniProtKB/TrEMBL. DT 11-DEC-2019, sequence version 1. DT 25-MAY-2022, entry version 7. DE RecName: Full=Sodium-dependent phosphate transport protein 2A {ECO:0000256|ARBA:ARBA00020021}; DE AltName: Full=Na(+)-dependent phosphate cotransporter 2A {ECO:0000256|ARBA:ARBA00031850}; DE AltName: Full=Sodium/phosphate cotransporter 2A {ECO:0000256|ARBA:ARBA00029614}; DE AltName: Full=Solute carrier family 34 member 1 {ECO:0000256|ARBA:ARBA00029764}; GN Name=SLC34A1 {ECO:0000313|Ensembl:ENSOCUP00000036892}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000036892, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Ensembl:ENSOCUP00000036892, ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000036892, RC ECO:0000313|Proteomes:UP000001811}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S., RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B., RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J., RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M., RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M., RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D., RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J., RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S., RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A., RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R., RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R., RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C., RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E., RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N., RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSOCUP00000036892} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000036892}; RG Ensembl; RL Submitted (OCT-2019) to UniProtKB. CC -!- FUNCTION: Involved in actively transporting phosphate into cells via CC Na(+) cotransport in the renal brush border membrane. Probably mediates CC 70-80% of the apical influx. {ECO:0000256|ARBA:ARBA00003658}. CC -!- SUBCELLULAR LOCATION: Apical cell membrane CC {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004424}. Cell membrane CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004651}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the SLC34A transporter family. CC {ECO:0000256|ARBA:ARBA00005808}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAGW02066618; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSOCUT00000059699; ENSOCUP00000036892; ENSOCUG00000002783. DR GeneTree; ENSGT00950000183177; -. DR Proteomes; UP000001811; Chromosome 3. DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005436; F:sodium:phosphate symporter activity; IEA:InterPro. DR GO; GO:0044341; P:sodium-dependent phosphate transport; IEA:InterPro. DR InterPro; IPR003841; Na/Pi_transpt. DR InterPro; IPR029848; Na/Pi_transpt_2A. DR PANTHER; PTHR10010; PTHR10010; 1. DR PANTHER; PTHR10010:SF21; PTHR10010:SF21; 1. DR Pfam; PF02690; Na_Pi_cotrans; 1. DR TIGRFAMs; TIGR01013; 2a58; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 107..132 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 144..163 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" SQ SEQUENCE 342 AA; 36932 MW; FA7E97CBA9DD3127 CRC64; MISYGEQLSS PAVSPPLVRA GLRGPMMHGA TFAYVPSPQA LHRIPGTSAY AFPSLSPVAL TEHGCPYGEA RERHEPLPAK LALEEEQKPE SGWAQELRRT AMTLLKLPLM VTFLYLFVCS LDVLSSAFQL AGGKVAGDIF KDNAILANPV AGLVVGILVT VLVQSSSTAT SIIVSMVSSG LLEVSSAIPI IMGSNIGTSV TNTIVALMQA GDRTDFRRAF AGATVHDCFN WLSVLVLLPL EAATGYLHHV TGLVVASFNI RGGRDAPDLL KTITEPFTKL IIQLDRSVIT SIATGDESLR NHSLIRIWCH RDPVEQSLGE REIARFHLHR KQAGERRGTC FL //