ID A0A5F9CT06_RABIT Unreviewed; 342 AA. AC A0A5F9CT06; DT 11-DEC-2019, integrated into UniProtKB/TrEMBL. DT 11-DEC-2019, sequence version 1. DT 27-NOV-2024, entry version 21. DE RecName: Full=Sodium-dependent phosphate transport protein 2A {ECO:0000256|ARBA:ARBA00020021}; DE AltName: Full=Na(+)-dependent phosphate cotransporter 2A {ECO:0000256|ARBA:ARBA00031850}; DE AltName: Full=Sodium/phosphate cotransporter 2A {ECO:0000256|ARBA:ARBA00029614}; DE AltName: Full=Solute carrier family 34 member 1 {ECO:0000256|ARBA:ARBA00029764}; GN Name=SLC34A1 {ECO:0000313|Ensembl:ENSOCUP00000036892.1}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000036892.1, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Ensembl:ENSOCUP00000036892.1, ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000036892.1, RC ECO:0000313|Proteomes:UP000001811}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S., RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B., RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J., RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M., RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M., RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D., RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J., RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S., RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A., RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R., RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R., RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C., RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E., RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N., RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSOCUP00000036892.1} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000036892.1}; RG Ensembl; RL Submitted (AUG-2024) to UniProtKB. CC -!- FUNCTION: Involved in actively transporting phosphate into cells via CC Na(+) cotransport in the renal brush border membrane. The cotransport CC has a Na(+):Pi stoichiometry of 3:1 and is electrogenic. CC {ECO:0000256|ARBA:ARBA00045420}. CC -!- CATALYTIC ACTIVITY: CC Reaction=3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in); CC Xref=Rhea:RHEA:71255, ChEBI:CHEBI:29101, ChEBI:CHEBI:43474; CC Evidence={ECO:0000256|ARBA:ARBA00034042}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71256; CC Evidence={ECO:0000256|ARBA:ARBA00034042}; CC -!- SUBUNIT: Interacts via its C-terminal region with NHERF4. Interacts CC with NHERF1. Interacts with TMEM174; regulates SLC34A1 internalization CC by PTH and FGF23. {ECO:0000256|ARBA:ARBA00046944}. CC -!- SUBCELLULAR LOCATION: Apical cell membrane CC {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004424}. CC -!- SIMILARITY: Belongs to the SLC34A transporter family. CC {ECO:0000256|ARBA:ARBA00005808}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAGW02066618; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; A0A5F9CT06; -. DR Ensembl; ENSOCUT00000059699.1; ENSOCUP00000036892.1; ENSOCUG00000002783.3. DR GeneTree; ENSGT00950000183177; -. DR Proteomes; UP000001811; Chromosome 3. DR Bgee; ENSOCUG00000002783; Expressed in kidney and 12 other cell types or tissues. DR GO; GO:0016324; C:apical plasma membrane; IEA:TreeGrafter. DR GO; GO:0005903; C:brush border; IEA:TreeGrafter. DR GO; GO:0031982; C:vesicle; IEA:TreeGrafter. DR GO; GO:0005436; F:sodium:phosphate symporter activity; IEA:InterPro. DR GO; GO:0030643; P:intracellular phosphate ion homeostasis; IEA:TreeGrafter. DR GO; GO:0044341; P:sodium-dependent phosphate transport; IEA:InterPro. DR InterPro; IPR003841; Na/Pi_transpt. DR NCBIfam; TIGR01013; 2a58; 1. DR NCBIfam; NF037997; Na_Pi_symport; 1. DR PANTHER; PTHR10010:SF21; SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2A; 1. DR PANTHER; PTHR10010; SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED; 1. DR Pfam; PF02690; Na_Pi_cotrans; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}; KW Sodium {ECO:0000256|ARBA:ARBA00023053}; KW Sodium transport {ECO:0000256|ARBA:ARBA00023201}; KW Symport {ECO:0000256|ARBA:ARBA00022847}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}. FT TRANSMEM 107..132 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 144..163 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" SQ SEQUENCE 342 AA; 36932 MW; FA7E97CBA9DD3127 CRC64; MISYGEQLSS PAVSPPLVRA GLRGPMMHGA TFAYVPSPQA LHRIPGTSAY AFPSLSPVAL TEHGCPYGEA RERHEPLPAK LALEEEQKPE SGWAQELRRT AMTLLKLPLM VTFLYLFVCS LDVLSSAFQL AGGKVAGDIF KDNAILANPV AGLVVGILVT VLVQSSSTAT SIIVSMVSSG LLEVSSAIPI IMGSNIGTSV TNTIVALMQA GDRTDFRRAF AGATVHDCFN WLSVLVLLPL EAATGYLHHV TGLVVASFNI RGGRDAPDLL KTITEPFTKL IIQLDRSVIT SIATGDESLR NHSLIRIWCH RDPVEQSLGE REIARFHLHR KQAGERRGTC FL //