ID A0A5F8MPT8_MOUSE Unreviewed; 695 AA. AC A0A5F8MPT8; DT 11-DEC-2019, integrated into UniProtKB/TrEMBL. DT 11-DEC-2019, sequence version 1. DT 25-MAY-2022, entry version 12. DE SubName: Full=Neuregulin 1 {ECO:0000313|Ensembl:ENSMUSP00000159112}; GN Name=Nrg1 {ECO:0000313|Ensembl:ENSMUSP00000159112, GN ECO:0000313|MGI:MGI:96083}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000159112, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000159112, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000159112, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000159112} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000159112}; RG Ensembl; RL Submitted (OCT-2019) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single- CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. CC -!- SIMILARITY: Belongs to the neuregulin family. CC {ECO:0000256|ARBA:ARBA00008216}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_006509135.1; XM_006509072.3. DR SMR; A0A5F8MPT8; -. DR Antibodypedia; 3706; 978 antibodies from 45 providers. DR DNASU; 211323; -. DR Ensembl; ENSMUST00000238842.2; ENSMUSP00000159112.2; ENSMUSG00000062991.10. DR GeneID; 211323; -. DR CTD; 3084; -. DR MGI; MGI:96083; Nrg1. DR VEuPathDB; HostDB:ENSMUSG00000062991; -. DR GeneTree; ENSGT00940000157326; -. DR Proteomes; UP000000589; Chromosome 8. DR GO; GO:0016324; C:apical plasma membrane; ISO:MGI. DR GO; GO:0030424; C:axon; IDA:MGI. DR GO; GO:0005737; C:cytoplasm; IDA:MGI. DR GO; GO:0005615; C:extracellular space; ISO:MGI. DR GO; GO:0098982; C:GABA-ergic synapse; IDA:SynGO. DR GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO. DR GO; GO:0005887; C:integral component of plasma membrane; IDA:MGI. DR GO; GO:0099061; C:integral component of postsynaptic density membrane; ISO:MGI. DR GO; GO:0099059; C:integral component of presynaptic active zone membrane; ISO:MGI. DR GO; GO:0031594; C:neuromuscular junction; IDA:MGI. DR GO; GO:0005654; C:nucleoplasm; ISO:MGI. DR GO; GO:0005886; C:plasma membrane; IDA:MGI. DR GO; GO:0045202; C:synapse; IDA:MGI. DR GO; GO:0045499; F:chemorepellent activity; IDA:MGI. DR GO; GO:0005176; F:ErbB-2 class receptor binding; IDA:MGI. DR GO; GO:0043125; F:ErbB-3 class receptor binding; ISO:MGI. DR GO; GO:0008083; F:growth factor activity; ISO:MGI. DR GO; GO:0005178; F:integrin binding; ISO:MGI. DR GO; GO:0030296; F:protein tyrosine kinase activator activity; ISO:MGI. DR GO; GO:0048018; F:receptor ligand activity; IDA:MGI. DR GO; GO:0030971; F:receptor tyrosine kinase binding; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:0003712; F:transcription coregulator activity; ISO:MGI. DR GO; GO:0032148; P:activation of protein kinase B activity; ISO:MGI. DR GO; GO:0007171; P:activation of transmembrane receptor protein tyrosine kinase activity; ISO:MGI. DR GO; GO:0048513; P:animal organ development; IBA:GO_Central. DR GO; GO:0003161; P:cardiac conduction system development; IDA:MGI. DR GO; GO:0060379; P:cardiac muscle cell myoblast differentiation; ISO:MGI. DR GO; GO:0048738; P:cardiac muscle tissue development; IDA:MGI. DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central. DR GO; GO:0016477; P:cell migration; IGI:MGI. DR GO; GO:0000902; P:cell morphogenesis; IDA:MGI. DR GO; GO:0008283; P:cell population proliferation; ISO:MGI. DR GO; GO:0021842; P:chemorepulsion involved in interneuron migration from the subpallium to the cortex; IMP:MGI. DR GO; GO:0060956; P:endocardial cell differentiation; ISO:MGI. DR GO; GO:0038127; P:ERBB signaling pathway; ISO:MGI. DR GO; GO:0038129; P:ERBB3 signaling pathway; ISO:MGI. DR GO; GO:0038130; P:ERBB4 signaling pathway; IDA:MGI. DR GO; GO:0038138; P:ERBB4-ERBB4 signaling pathway; ISO:MGI. DR GO; GO:0010001; P:glial cell differentiation; IMP:MGI. DR GO; GO:0021781; P:glial cell fate commitment; IDA:MGI. DR GO; GO:0007507; P:heart development; IMP:MGI. DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central. DR GO; GO:0007626; P:locomotory behavior; IMP:MGI. DR GO; GO:0000165; P:MAPK cascade; IDA:MGI. DR GO; GO:0007613; P:memory; ISO:MGI. DR GO; GO:0007517; P:muscle organ development; IMP:MGI. DR GO; GO:0022011; P:myelination in peripheral nervous system; IMP:MGI. DR GO; GO:0010667; P:negative regulation of cardiac muscle cell apoptotic process; ISO:MGI. DR GO; GO:2000853; P:negative regulation of corticosterone secretion; ISO:MGI. DR GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; ISO:MGI. DR GO; GO:2001223; P:negative regulation of neuron migration; IDA:MGI. DR GO; GO:0042177; P:negative regulation of protein catabolic process; IDA:MGI. DR GO; GO:0051048; P:negative regulation of secretion; ISO:MGI. DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI. DR GO; GO:0007399; P:nervous system development; IMP:MGI. DR GO; GO:0048663; P:neuron fate commitment; IMP:MGI. DR GO; GO:0045213; P:neurotransmitter receptor metabolic process; IMP:MGI. DR GO; GO:0048709; P:oligodendrocyte differentiation; IMP:MGI. DR GO; GO:0007422; P:peripheral nervous system development; IMP:MGI. DR GO; GO:0048680; P:positive regulation of axon regeneration; ISO:MGI. DR GO; GO:0070886; P:positive regulation of calcineurin-NFAT signaling cascade; IGI:MGI. DR GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; ISO:MGI. DR GO; GO:0045785; P:positive regulation of cell adhesion; ISO:MGI. DR GO; GO:0030307; P:positive regulation of cell growth; ISO:MGI. DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:MGI. DR GO; GO:0010628; P:positive regulation of gene expression; IDA:MGI. DR GO; GO:0010976; P:positive regulation of neuron projection development; ISO:MGI. DR GO; GO:1900086; P:positive regulation of peptidyl-tyrosine autophosphorylation; ISO:MGI. DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:MGI. DR GO; GO:0045860; P:positive regulation of protein kinase activity; IDA:MGI. DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; IDA:MGI. DR GO; GO:0031334; P:positive regulation of protein-containing complex assembly; ISO:MGI. DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IDA:MGI. DR GO; GO:0010625; P:positive regulation of Schwann cell proliferation; ISO:MGI. DR GO; GO:0099527; P:postsynapse to nucleus signaling pathway; IDA:SynGO. DR GO; GO:0032984; P:protein-containing complex disassembly; ISO:MGI. DR GO; GO:0045595; P:regulation of cell differentiation; IMP:MGI. DR GO; GO:0099149; P:regulation of postsynaptic neurotransmitter receptor internalization; ISO:MGI. DR GO; GO:0007416; P:synapse assembly; IDA:SynGO. DR GO; GO:0099560; P:synaptic membrane adhesion; ISO:MGI. DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; ISO:MGI. DR GO; GO:0055012; P:ventricular cardiac muscle cell differentiation; ISO:MGI. DR GO; GO:0003222; P:ventricular trabecula myocardium morphogenesis; ISO:MGI. DR GO; GO:0042060; P:wound healing; ISO:MGI. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR040180; Neuregulin. DR InterPro; IPR002154; Neuregulin_C. DR InterPro; IPR018250; NRG1. DR PANTHER; PTHR11100; PTHR11100; 1. DR Pfam; PF00008; EGF; 1. DR Pfam; PF02158; Neuregulin; 1. DR PRINTS; PR01089; NEUREGULIN. DR SMART; SM00181; EGF; 1. DR PROSITE; PS00022; EGF_1; 1. DR PROSITE; PS01186; EGF_2; 1. DR PROSITE; PS50026; EGF_3; 1. PE 1: Evidence at protein level; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE- KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0007829|MaxQB:A0A5F8MPT8, KW ECO:0007829|ProteomicsDB:A0A5F8MPT8}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 76..99 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 298..320 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 233..277 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT REGION 1..46 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 165..227 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 390..414 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 430..456 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 483..513 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 581..643 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 13..27 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 183..197 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 200..227 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT DISULFID 267..276 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" SQ SEQUENCE 695 AA; 75727 MW; 1CF1810BFFDF1C06 CRC64; MEIYPPDMSE GAGGRSSSPS TQLSADPSLD GLPAAEHMPD THTEDGRSPG LLGLAVPCCV CLEAERLRGC LNSEKICIVP ILACLVSLCL CIAGLKWVFV DKIFEYDSPT HLDPGGLGQD PVISLDPTAA SAVLVSSEAY TSPVSKAQSE AEAHVTGQGD HVAVASEPSA VPTRKNRLSA FPPLHSTPPP FPSPARTPEV RTPKSGTQPQ TTETNLQTAP KLSTSTSTTG TSHLIKCAEK EKTFCVNGGE CFMVKDLSNP SRYLCKCQPG FTGARCTENV PMKVQTQEKA EELYQKRVLT ITGICIALLV VGIMCVVAYC KTKKQRQKLH DRLRQSLRSE RNNMVNIANG PHHPNPPPEN VQLVNQYVSK NVISSEHIVE REVETSFSTS HYTSTAHHST TVTQTPSHSW SNGHTESIIS ESHSVIMMSS VENSRHSSPA GGPRGRLHGL GGPRECNSFL RHARETPDSY RDSPHSERYV SAMTTPARMS PVDFHTPSSP KSPPSEMSPP VSSMTVSMPS VAVSPFVEEE RPLLLVTPPR LREKKYDHHP QQLNSFHHNP AHQSTSLPPS PLRIVEDEEY ETTQEYEPIQ EPIKKVTNSR RAKRTKPNGH IANRLEMDSN PSSVSSNSES ETEDERVGED TPFLGIQNPL AASLEVAPAF RLAESRTNPA GRFSTQEELQ ARLSSVIANQ DPIAV //