ID A0A5F8HJ05_MONDO Unreviewed; 116 AA. AC A0A5F8HJ05; DT 11-DEC-2019, integrated into UniProtKB/TrEMBL. DT 11-DEC-2019, sequence version 1. DT 02-OCT-2024, entry version 23. DE RecName: Full=Succinate dehydrogenase cytochrome b560 subunit, mitochondrial {ECO:0000256|ARBA:ARBA00014631}; DE AltName: Full=Malate dehydrogenase [quinone] cytochrome b560 subunit {ECO:0000256|ARBA:ARBA00045023}; GN Name=SDHC {ECO:0000313|Ensembl:ENSMODP00000059834.1}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000059834.1, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000059834.1, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S., RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M., RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V., RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E., RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A., RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S., RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E., RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K., RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C., RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J., RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P., RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A., RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L., RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M., RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K., RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J., RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A., RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R., RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L., RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C., RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L., RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F., RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T., RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J., RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S., RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I., RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in non- RT coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000059834.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2024) to UniProtKB. CC -!- COFACTOR: CC Name=heme; Xref=ChEBI:CHEBI:30413; CC Evidence={ECO:0000256|PIRSR:PIRSR000178-1}; CC Note=The heme is bound between the two transmembrane subunits. CC {ECO:0000256|PIRSR:PIRSR000178-1}; CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle. CC {ECO:0000256|ARBA:ARBA00005163}. CC -!- SUBUNIT: Component of complex II composed of four subunits: the CC flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome CC b560 composed of SDHC and SDHD. {ECO:0000256|ARBA:ARBA00011758}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A5F8HJ05; -. DR Ensembl; ENSMODT00000053401.1; ENSMODP00000059834.1; ENSMODG00000005031.4. DR GeneTree; ENSGT00390000000566; -. DR Proteomes; UP000002280; Chromosome 2. DR Bgee; ENSMODG00000005031; Expressed in skeletal muscle tissue and 21 other cell types or tissues. DR GO; GO:0005739; C:mitochondrion; IEA:UniProt. DR GO; GO:0045281; C:succinate dehydrogenase complex; IEA:InterPro. DR GO; GO:0009055; F:electron transfer activity; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro. DR CDD; cd03499; SQR_TypeC_SdhC; 1. DR Gene3D; 1.20.1300.10; Fumarate reductase/succinate dehydrogenase, transmembrane subunit; 1. DR InterPro; IPR034804; SQR/QFR_C/D. DR InterPro; IPR018495; Succ_DH_cyt_bsu_CS. DR InterPro; IPR014314; Succ_DH_cytb556. DR InterPro; IPR000701; SuccDH_FuR_B_TM-su. DR NCBIfam; TIGR02970; succ_dehyd_cytB; 1. DR PANTHER; PTHR10978; SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT; 1. DR PANTHER; PTHR10978:SF5; SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL; 1. DR Pfam; PF01127; Sdh_cyt; 1. DR PIRSF; PIRSF000178; SDH_cyt_b560; 1. DR SUPFAM; SSF81343; Fumarate reductase respiratory complex transmembrane subunits; 1. DR PROSITE; PS01001; SDH_CYT_2; 1. PE 4: Predicted; KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|PIRSR:PIRSR000178-1}; KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR000178-1}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, KW ECO:0000256|PIRSR:PIRSR000178-1}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1..15 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 16..116 FT /note="Succinate dehydrogenase cytochrome b560 subunit, FT mitochondrial" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5023848941" FT TRANSMEM 25..43 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 96..115 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT BINDING 74 FT /ligand="heme" FT /ligand_id="ChEBI:CHEBI:30413" FT /ligand_note="ligand shared with second transmembrane FT subunit" FT /ligand_part="Fe" FT /ligand_part_id="ChEBI:CHEBI:18248" FT /note="axial binding residue" FT /evidence="ECO:0000256|PIRSR:PIRSR000178-1" SQ SEQUENCE 116 AA; 12265 MW; 44736453E7A2895F CRC64; MAALLLSWSL PMAMSICHRA SGIALSAGVS LFGLAALLLP GNFESHVELL KSLSLGPALI HTAKFALVSP LMYHTWNGIR HLTWDLGMGL KIPQLYQSGV VVLALTVLSS IGLAAM //