ID A0A5E8G1S1_ECOLX Unreviewed; 440 AA. AC A0A5E8G1S1; DT 13-NOV-2019, integrated into UniProtKB/TrEMBL. DT 13-NOV-2019, sequence version 1. DT 07-APR-2021, entry version 8. DE RecName: Full=Thymidine phosphorylase {ECO:0000256|HAMAP-Rule:MF_01628}; DE EC=2.4.2.4 {ECO:0000256|HAMAP-Rule:MF_01628}; DE AltName: Full=TdRPase {ECO:0000256|HAMAP-Rule:MF_01628}; GN Name=deoA {ECO:0000256|HAMAP-Rule:MF_01628, GN ECO:0000313|EMBL:CDU33021.1}; GN ORFNames=PGA_01032 {ECO:0000313|EMBL:CDU33021.1}; OS Escherichia coli D6-113.11. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=1400022 {ECO:0000313|EMBL:CDU33021.1}; RN [1] {ECO:0000313|EMBL:CDU33021.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=D6-113.11 {ECO:0000313|EMBL:CDU33021.1}; RA Kempf F., Loux V., Germon P.; RT "Genome sequence of four bovine mastitis-causing Escherichia coli RT strains."; RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The enzymes which catalyze the reversible phosphorolysis of CC pyrimidine nucleosides are involved in the degradation of these CC compounds and in their utilization as carbon and energy sources, or in CC the rescue of pyrimidine bases for nucleotide synthesis. CC {ECO:0000256|HAMAP-Rule:MF_01628}. CC -!- CATALYTIC ACTIVITY: CC Reaction=phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + CC thymine; Xref=Rhea:RHEA:16037, ChEBI:CHEBI:17748, ChEBI:CHEBI:17821, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; EC=2.4.2.4; CC Evidence={ECO:0000256|ARBA:ARBA00000749, ECO:0000256|HAMAP- CC Rule:MF_01628}; CC -!- PATHWAY: Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; CC dTMP from thymine: step 1/2. {ECO:0000256|HAMAP-Rule:MF_01628}. CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738, ECO:0000256|HAMAP- CC Rule:MF_01628}. CC -!- SIMILARITY: Belongs to the thymidine/pyrimidine-nucleoside CC phosphorylase family. {ECO:0000256|ARBA:ARBA00006915, CC ECO:0000256|HAMAP-Rule:MF_01628}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HG977177; CDU33021.1; -; Genomic_DNA. DR RefSeq; WP_000477811.1; NZ_HG977177.1. DR SMR; A0A5E8G1S1; -. DR GeneID; 58461394; -. DR UniPathway; UPA00578; UER00638. DR GO; GO:0004645; F:1,4-alpha-oligoglucan phosphorylase activity; IEA:InterPro. DR GO; GO:0016154; F:pyrimidine-nucleoside phosphorylase activity; IEA:InterPro. DR GO; GO:0009032; F:thymidine phosphorylase activity; IEA:UniProtKB-UniRule. DR GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:InterPro. DR GO; GO:0046104; P:thymidine metabolic process; IEA:UniProtKB-UniRule. DR Gene3D; 1.20.970.10; -; 1. DR Gene3D; 3.40.1030.10; -; 1. DR Gene3D; 3.90.1170.30; -; 1. DR HAMAP; MF_01628; Thymid_phosp; 1. DR InterPro; IPR000312; Glycosyl_Trfase_fam3. DR InterPro; IPR017459; Glycosyl_Trfase_fam3_N_dom. DR InterPro; IPR036320; Glycosyl_Trfase_fam3_N_dom)sf. DR InterPro; IPR035902; Nuc_phospho_transferase. DR InterPro; IPR036566; PYNP-like_C_sf. DR InterPro; IPR013102; PYNP_C. DR InterPro; IPR018090; Pyrmidine_PPas_bac/euk. DR InterPro; IPR017872; Pyrmidine_PPase_CS. DR InterPro; IPR000053; Thymidine/pyrmidine_PPase. DR InterPro; IPR013465; Thymidine_Pase. DR PANTHER; PTHR10515; PTHR10515; 1. DR Pfam; PF02885; Glycos_trans_3N; 1. DR Pfam; PF00591; Glycos_transf_3; 1. DR Pfam; PF07831; PYNP_C; 1. DR PIRSF; PIRSF000478; TP_PyNP; 1. DR SMART; SM00941; PYNP_C; 1. DR SUPFAM; SSF47648; SSF47648; 1. DR SUPFAM; SSF52418; SSF52418; 1. DR SUPFAM; SSF54680; SSF54680; 1. DR TIGRFAMs; TIGR02643; T_phosphoryl; 1. DR TIGRFAMs; TIGR02644; Y_phosphoryl; 1. DR PROSITE; PS00647; THYMID_PHOSPHORYLASE; 1. PE 3: Inferred from homology; KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676, ECO:0000256|HAMAP- KW Rule:MF_01628}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP- KW Rule:MF_01628}. SQ SEQUENCE 440 AA; 47180 MW; B3BDF83C9275D2F1 CRC64; MFLAQEIIRK KRDGHALSDE EIRFFINGIR DNTISEGQIA ALAMTIFFHD MTMPERVSLT MAMRDSGTVL DWKSLHLNGP IVDKHSTGGV GDVTSLMLGP MVAACGGYIP MISGRGLGHT GGTLDKLESI PGFDIFPDDN RFREIIKDVG VAIIGQTSSL APADKRFYAT RDITATVDSI PLITASILAK KLAEGLDALV MDVKVGSGAF MPTYELSEAL AEAIVGVANG AGVRTTALLT DMNQVLASSA GNAVEVREAV QFLTGEYRNP RLFDVTMALC VEMLISGKLA KDDAEARAKL QAVLDNGKAA EVFGRMVAAQ KGPTDFVENY AKYLPTAMLT KAVYADTEGF VSEMDTRALG MAVVAMGGGR RQASDTIDYS VGFTDMARLG DQVDGQRPLA VIHAKDENSW QEAAKAVKAA IKLADKAPES TPTVYRRISE //