ID A0A5C6PGU5_9TELE Unreviewed; 586 AA. AC A0A5C6PGU5; DT 13-NOV-2019, integrated into UniProtKB/TrEMBL. DT 13-NOV-2019, sequence version 1. DT 12-AUG-2020, entry version 5. DE SubName: Full=Cytosolic purine 5'-nucleotidase {ECO:0000313|EMBL:TWW78061.1}; GN ORFNames=D4764_11G0001820 {ECO:0000313|EMBL:TWW78061.1}; OS Takifugu flavidus (sansaifugu). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu. OX NCBI_TaxID=433684 {ECO:0000313|EMBL:TWW78061.1, ECO:0000313|Proteomes:UP000324091}; RN [1] {ECO:0000313|EMBL:TWW78061.1, ECO:0000313|Proteomes:UP000324091} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=HTHZ2018 {ECO:0000313|EMBL:TWW78061.1}; RC TISSUE=Muscle {ECO:0000313|EMBL:TWW78061.1}; RA Xiao S.; RT "Chromosome genome assembly for Takifugu flavidus."; RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases. CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|PIRSR:PIRSR017434-2}; CC Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR017434-2}; CC -!- SIMILARITY: Belongs to the 5'(3')-deoxyribonucleotidase family. CC {ECO:0000256|ARBA:ARBA00009589}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:TWW78061.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; RHFK02000003; TWW78061.1; -; Genomic_DNA. DR Proteomes; UP000324091; Chromosome 11. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR Gene3D; 3.40.50.1000; -; 2. DR InterPro; IPR036412; HAD-like_sf. DR InterPro; IPR008380; HAD-SF_hydro_IG_5-nucl. DR InterPro; IPR023214; HAD_sf. DR InterPro; IPR016695; Pur_nucleotidase. DR PANTHER; PTHR12103; PTHR12103; 1. DR Pfam; PF05761; 5_nucleotid; 1. DR PIRSF; PIRSF017434; Purine_5'-nucleotidase; 1. DR SUPFAM; SSF56784; SSF56784; 1. DR TIGRFAMs; TIGR02244; HAD-IG-Ncltidse; 1. PE 3: Inferred from homology; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|PIRSR:PIRSR017434-2}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, KW ECO:0000256|PIRSR:PIRSR017434-2}; KW Reference proteome {ECO:0000313|Proteomes:UP000324091}. FT REGION 552..586 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 572..586 FT /note="Acidic" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT ACT_SITE 65 FT /note="Nucleophile" FT /evidence="ECO:0000256|PIRSR:PIRSR017434-1" FT ACT_SITE 67 FT /note="Proton donor" FT /evidence="ECO:0000256|PIRSR:PIRSR017434-1" FT METAL 65 FT /note="Magnesium" FT /evidence="ECO:0000256|PIRSR:PIRSR017434-2" FT METAL 67 FT /note="Magnesium; via carbonyl oxygen" FT /evidence="ECO:0000256|PIRSR:PIRSR017434-2" FT METAL 375 FT /note="Magnesium" FT /evidence="ECO:0000256|PIRSR:PIRSR017434-2" FT BINDING 140 FT /note="Allosteric activator 1" FT /evidence="ECO:0000256|PIRSR:PIRSR017434-3" FT BINDING 167 FT /note="Allosteric activator 2" FT /evidence="ECO:0000256|PIRSR:PIRSR017434-3" FT BINDING 378 FT /note="Allosteric activator 2" FT /evidence="ECO:0000256|PIRSR:PIRSR017434-3" FT BINDING 460 FT /note="Allosteric activator 1; via carbonyl oxygen" FT /evidence="ECO:0000256|PIRSR:PIRSR017434-3" FT BINDING 477 FT /note="Allosteric activator 2" FT /evidence="ECO:0000256|PIRSR:PIRSR017434-3" SQ SEQUENCE 586 AA; 68131 MW; 233D3656B043DD20 CRC64; MIKALLEKRL LQFKMTSWSD RLQNYADLPV NMDGLALKKY RREAHHRVFV NRSLAMEKIK CFGFDMDYTL AVYKSPEYES LGFDLTVERL VSIGYPQELL NFVYDPSFPT RGLVFDTLYG NLLKVDTYGN ILVCVHGFNF LRGPEIREKY PNKFIQRGDT ERFYILNTLF NLPETYLFAC LVDFFSNCSR YTSCETGFKD GDLFMSYKSM FQDVRDGVDW VHFKGSLKEK TVENLEKYVV KDSNISFFLP SNKPKLPLLL SRMKEVAKVF LATNSDYKYT EKIMTYLFDF AHGPKPGMPH RPWQSYFDLI LVDARKPVFF AEGTVLRQVD TTTGRLKIGT YTGPLQHGIV YSGGSSDIVC DLMGIKGKDI IYIGDHIFGD ILKSKKRQGW RTFLVIPELA QELHVWTDKS SIFEELQSLD CFLAELYKHL DSSSNERPDI SSLQRRIKKI THDMDMCYGM MGSLFRSGSR QTLFASQVMR YADLYAASFI NLLYYPFSYL FRAAHVLMPH ESTVEHAHVS FIDTESPLAT RNRHDVDLKE MECKRHQLTR SVSEIQPPHL YPQTPQEITH CHDEDDDEEE EEEEEE //