ID   A0A5B8YY64_LEITR        Unreviewed;       244 AA.
AC   A0A5B8YY64;
DT   13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2019, sequence version 1.
DT   12-AUG-2020, entry version 5.
DE   RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE            EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
DE   Flags: Fragment;
OS   Leishmania tropica.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5666 {ECO:0000313|EMBL:QED45680.1};
RN   [1] {ECO:0000313|EMBL:QED45680.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MHOM/SU/74/K-27 {ECO:0000313|EMBL:QED45680.1};
RA   Lauthier J.J., Ruybal P., Barroso P.A., Hashiguchi Y., Marco J.D.,
RA   Korenaga M.;
RT   "Development of a consensus Multilocus Sequence Typing scheme (MLST) to
RT   resolve the major taxonomical levels of Leishmania species.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 1/4.
CC       {ECO:0000256|ARBA:ARBA00004888}.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|ARBA:ARBA00009225, ECO:0000256|RuleBase:RU362007}.
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DR   EMBL; MH455530; QED45680.1; -; Genomic_DNA.
DR   UniPathway; UPA00109; UER00180.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IEA:InterPro.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00378; HEXOKINASE_1; 1.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362007};
KW   Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|RuleBase:RU362007};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU362007,
KW   ECO:0000313|EMBL:QED45680.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU362007};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362007}.
FT   DOMAIN          6..118
FT                   /note="Hexokinase_1"
FT                   /evidence="ECO:0000259|Pfam:PF00349"
FT   DOMAIN          125..242
FT                   /note="Hexokinase_2"
FT                   /evidence="ECO:0000259|Pfam:PF03727"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:QED45680.1"
FT   NON_TER         244
FT                   /evidence="ECO:0000313|EMBL:QED45680.1"
SQ   SEQUENCE   244 AA;  26903 MW;  F7F35305311A8E87 CRC64;
     GKVDDRTDSK FVIPKSALVG DATDLFDFIA QSVKKMMSEN APDDLEKRVP LGFTFSFPVD
     QKAVNKGLLI KWTKGFSTKN VEGNDVVELL QASLRRVRVN VNVVALCNDT VGTLVARYFV
     DTDVQVGVII GTGSNACYFE RASAVTKDPA VSARGNAVTP INMECGNFDS KYKYALPITV
     YDDEMDAITP NRENQRQEKL VSGMYLGEIS RRLIVHLAQL GCLPRGLVDG LCRPWAFESK
     HMGM
//