ID A0A5B8HVF5_9VIRU Unreviewed; 613 AA. AC A0A5B8HVF5; DT 13-NOV-2019, integrated into UniProtKB/TrEMBL. DT 13-NOV-2019, sequence version 1. DT 19-JAN-2022, entry version 7. DE RecName: Full=MGS-like domain-containing protein {ECO:0000259|PROSITE:PS51855}; GN ORFNames=3_28 {ECO:0000313|EMBL:QDY52049.1}; OS Mimiviridae sp. ChoanoV1. OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes; OC Imitervirales; Mimiviridae; unclassified Mimiviridae. OX NCBI_TaxID=2596887 {ECO:0000313|EMBL:QDY52049.1}; RN [1] {ECO:0000313|EMBL:QDY52049.1} RP NUCLEOTIDE SEQUENCE. RA Needham D.M., Yoshizawa S., Hosaka T., Poirier C., Choi C.-J., RA Hehenberger E., Irwin N.A.T., Wilken S., Yung C.-M., Bachy C., Kurihara R., RA Nakajima Y., Kojima K., Kimura-Someya T., Leonard G., Malmstrom R.R., RA Mende D., Olson D.K., Sudo Y., Sudek S., Richards T.A., DeLong E.F., RA Keeling P.J., Santoro A.E., Shirouzu M., Iwasaki W., Worden A.Z.; RT "A distinct lineage of giant viruses engineers rhodopsin photosystems in RT predatory marine eukaryotes."; RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases. CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5- CC formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino- CC 1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): CC step 1/1. {ECO:0000256|ARBA:ARBA00004954}. CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; IMP CC from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step CC 1/1. {ECO:0000256|ARBA:ARBA00004844}. CC -!- SIMILARITY: Belongs to the PurH family. CC {ECO:0000256|ARBA:ARBA00007667}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MK250087; QDY52049.1; -; Genomic_DNA. DR UniPathway; UPA00074; UER00133. DR GO; GO:0003937; F:IMP cyclohydrolase activity; IEA:UniProtKB-EC. DR GO; GO:0004643; F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity; IEA:UniProtKB-EC. DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway. DR Gene3D; 1.10.287.440; -; 1. DR Gene3D; 3.40.140.20; -; 2. DR Gene3D; 3.40.50.1380; -; 1. DR InterPro; IPR024051; AICAR_Tfase_dup_dom_sf. DR InterPro; IPR024050; AICAR_Tfase_insert_dom_sf. DR InterPro; IPR016193; Cytidine_deaminase-like. DR InterPro; IPR011607; MGS-like_dom. DR InterPro; IPR036914; MGS-like_dom_sf. DR InterPro; IPR002695; PurH-like. DR PANTHER; PTHR11692; PTHR11692; 1. DR Pfam; PF01808; AICARFT_IMPCHas; 1. DR Pfam; PF02142; MGS; 1. DR PIRSF; PIRSF000414; AICARFT_IMPCHas; 1. DR SMART; SM00798; AICARFT_IMPCHas; 1. DR SMART; SM00851; MGS; 1. DR SUPFAM; SSF52335; SSF52335; 1. DR SUPFAM; SSF53927; SSF53927; 1. DR PROSITE; PS51855; MGS; 1. PE 3: Inferred from homology; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268}; KW Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 1..161 FT /note="MGS-like" FT /evidence="ECO:0000259|PROSITE:PS51855" SQ SEQUENCE 613 AA; 70393 MW; 50E671CD39D5D668 CRC64; MKLALVSVSD KSNLSVLVSY LLKNNFNIIS TGGTYKYIIE NIENNNIDLD TLEIHKRIIP VENFTGFPEI LGGRVKTLHP KIYGGILYDS SILEHVKDFE KFNDTMYKLE KIDLVVVNLY PFSYTVERMK EPDEIIENID IGGVSLIRAA AKNYKNVLVL TNPKDYNNFI HTYGYYSNLE IFRKELSLKA FQHTIEYDQN IVNYFDKRIR YRKYVEQQPI KYGCNPYQTN AFISSINDNT FPLKIINGNP GYINYLDALN SWLLVSEAHK NLGYITSTSF KHTAPAGVGI SRGEILDSEI ILYDLENYTK EELNKSHTAR AYVRARNCDA LSSFGDFIAI SGIVDETCAK LIKREVSDGI IAKGYTKDAY HILKQKKKGR YPILEGKCDI NYNRLEYREI MGLAMTQSCN DEIITDEYFK MVPTKNMEIL QDKKEDLTLA TITLKYTPSN SITIANNGQV IGIGSGQQNR VDCIKLAGNK ANIFNLKRHP KSINLLSKFK DGIKRQDKIN AVIKYVNGDF TDKELINWKL LFTEEIELLS ENEKKDFLDE NYQNLVLSSD AFFPFRDNID YANRFNIKYI LNPGGSIQDN NIIDACDEYE MYMAITGKRL FLH //