ID A0A556UYM0_BAGYA Unreviewed; 1041 AA. AC A0A556UYM0; DT 16-OCT-2019, integrated into UniProtKB/TrEMBL. DT 16-OCT-2019, sequence version 1. DT 13-NOV-2019, entry version 2. DE SubName: Full=Fibroblast growth factor receptor 4 {ECO:0000313|EMBL:TSP68524.1}; GN ORFNames=Baya_11009 {ECO:0000313|EMBL:TSP68524.1}; OS Bagarius yarrelli (Goonch) (Bagrus yarrelli). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes; OC Sisoridae; Sisorinae; Bagarius. OX NCBI_TaxID=175774 {ECO:0000313|EMBL:TSP68524.1}; RN [1] {ECO:0000313|EMBL:TSP68524.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=JWS20170419001 {ECO:0000313|EMBL:TSP68524.1}; RC TISSUE=Muscle {ECO:0000313|EMBL:TSP68524.1}; RX PubMed=31274158; RA Jiang W., Lv Y., Cheng L., Yang K., Chao B., Wang X., Li Y., Pan X., RA You X., Zhang Y., Yang J., Li J., Zhang X., Liu S., Sun C., Yang J., RA Shi Q.; RT "Whole genome sequencing of the giant devil catfish, Bagarius RT yarrelli."; RL Genome Biol. Evol. 0:0-0(2019). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L- CC tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, CC Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; CC EC=2.7.10.1; Evidence={ECO:0000256|SAAS:SAAS01168082}; CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein CC kinase family. {ECO:0000256|SAAS:SAAS00941529}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:TSP68524.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; VCAZ01000078; TSP68524.1; -; Genomic_DNA. DR Gene3D; 2.60.40.10; -; 4. DR InterPro; IPR041159; FGFR_TM. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom. DR InterPro; IPR008266; Tyr_kinase_AS. DR InterPro; IPR020635; Tyr_kinase_cat_dom. DR Pfam; PF18123; FGFR3_TM; 1. DR Pfam; PF07679; I-set; 2. DR Pfam; PF07714; Pkinase_Tyr; 1. DR PRINTS; PR00109; TYRKINASE. DR SMART; SM00409; IG; 4. DR SMART; SM00408; IGc2; 4. DR SMART; SM00219; TyrKc; 1. DR SUPFAM; SSF48726; SSF48726; 4. DR SUPFAM; SSF56112; SSF56112; 1. DR PROSITE; PS50835; IG_LIKE; 4. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|SAAS:SAAS00600564}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00916669}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00941986}; KW Kinase {ECO:0000256|SAAS:SAAS00601152}; KW Membrane {ECO:0000256|SAAS:SAAS00602125, ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|SAAS:SAAS00600689}; KW Receptor {ECO:0000256|SAAS:SAAS00600436, ECO:0000313|EMBL:TSP68524.1}; KW Repeat {ECO:0000256|SAAS:SAAS00295312}; KW Transferase {ECO:0000256|SAAS:SAAS00601608}; KW Transmembrane {ECO:0000256|SAAS:SAAS00600943, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00602683, KW ECO:0000256|SAM:Phobius}; KW Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00582553}. FT TRANSMEM 600 620 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 139 236 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 256 343 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 377 470 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 479 579 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 697 985 Protein kinase. {ECO:0000259|PROSITE: FT PS50011}. FT REGION 1 25 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 348 367 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 9 25 Polyampholyte. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 349 363 Acidic. {ECO:0000256|SAM:MobiDB-lite}. SQ SEQUENCE 1041 AA; 116997 MW; C13BE2CE0AF62FED CRC64; MVQFNQKHRV HTEFPKEKRE RETNPGKTVA EAISISVKTA GCWTFVACVL AAEGNLHYKV GLSITTIVNP RPVFSSTGRY PEVSNAWSQR LSGLQEKRFL GKMWSIWKFF ITLCLAEFVL SKSITTQAIR AKDSRVHRPT LQPGFPENTT VLLGGQAKLV CKVHRPATTR LQWFKRDKDR LGPDGSPLLK PLTLLQDNIS KVNILPLVNV TLEDAGEYIC MAKNSAGRTS NSAWVEVLTE ILLAKSVDQL TVAENPTEVS EELSEDTSEH LLLEPGDVLK LRCDTNRPGA VHWFKGDIRV QHSGRIQIKA GVIEITDARY EDSGVYVCMV RGSREPLRNF TITVADAVGS GDDDEDAGQE DSVTETENDQ VFISKGPYWT HIQRMEKKLY AVPAGNTVKF RCPATGSPTP SIRWLKNGRE FRGEHRIGGI KLRHQHWSLV MESVVPSDRG NYTCVVENKY GSITHSYLLD VLERSPHRPI LQAGLPTNTT AVVGGDAQFH CKVYSDAQPH IQWLKHIEIN GSRYGPDGIP YVKVVKTGSL NMSEVEVLYL TNITMEDAGE YTCLAGNSIG FSHQSAWLTV LSEEDVAKEM DLMETKYTDI IIYASGFLAL VMAIVIVVLC RMQTHPSREH FDALPVQKLS KFPLRRQYSV ESNSSGKSSA SLMRVARLSS SCSPMLAGVM EFELPYDPDW EFPRENLTLG KPLGEGCFGQ VVRAEAYGIN RDNPEQVTTV AVKMLKDDAT DKDLADLISE MELMKGMDKH KNIINLLGVC TQEGPLYVLV EYASKGSLRE YLRARRPPGM DYTFDVTKVP EEQLTFKDLL SCAYQVARGM EYLASKRCIH RDLAARNVLV TEDNVMKIAD FGLARGVHQI DYYKKTTNGR LPVKWMAPEA LFDRVYTHQS DVWSFGVLMW EIFTLGGSPY PGIPVEELFK LLKEGHRMDK PSNCTHELYM KMRECWHAVP TQRPTFKQLV EELDRVLLSI SDEYLDLSTP FEQYSPSCED TSSSCSSDND SVFTHDALST DPCLLGYHDV RSRIDVKTSL R //