ID A0A556U1S0_BAGYA Unreviewed; 2466 AA. AC A0A556U1S0; DT 16-OCT-2019, integrated into UniProtKB/TrEMBL. DT 16-OCT-2019, sequence version 1. DT 12-AUG-2020, entry version 6. DE RecName: Full=ATP-dependent helicase ATRX {ECO:0000256|ARBA:ARBA00017302}; DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551}; DE AltName: Full=Transcriptional regulator ATRX {ECO:0000256|ARBA:ARBA00016932}; GN ORFNames=Baya_7339 {ECO:0000313|EMBL:TSL89850.1}; OS Bagarius yarrelli (Goonch) (Bagrus yarrelli). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes; OC Sisoridae; Sisorinae; Bagarius. OX NCBI_TaxID=175774 {ECO:0000313|EMBL:TSL89850.1, ECO:0000313|Proteomes:UP000319801}; RN [1] {ECO:0000313|EMBL:TSL89850.1, ECO:0000313|Proteomes:UP000319801} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JWS20170419001 {ECO:0000313|EMBL:TSL89850.1}; RC TISSUE=Muscle {ECO:0000313|EMBL:TSL89850.1}; RX PubMed=31274158; RA Jiang W., Lv Y., Cheng L., Yang K., Chao B., Wang X., Li Y., Pan X., RA You X., Zhang Y., Yang J., Li J., Zhang X., Liu S., Sun C., Yang J., RA Shi Q.; RT "Whole-Genome Sequencing of the Giant Devil Catfish, Bagarius yarrelli."; RL Genome Biol. Evol. 11:2071-2077(2019). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; CC Evidence={ECO:0000256|ARBA:ARBA00001665}; CC -!- SUBCELLULAR LOCATION: Chromosome, telomere CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus CC {ECO:0000256|ARBA:ARBA00004123}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:TSL89850.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; VCAZ01000038; TSL89850.1; -; Genomic_DNA. DR Proteomes; UP000319801; Unassembled WGS sequence. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR Gene3D; 3.30.40.10; -; 1. DR Gene3D; 3.40.50.10810; -; 1. DR InterPro; IPR025766; ADD. DR InterPro; IPR041430; ADD_ATRX. DR InterPro; IPR014001; Helicase_ATP-bd. DR InterPro; IPR001650; Helicase_C. DR InterPro; IPR007758; Nucleoporin_NSP1_C. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR038718; SNF2-like_sf. DR InterPro; IPR000330; SNF2_N. DR InterPro; IPR011011; Znf_FYVE_PHD. DR InterPro; IPR013083; Znf_RING/FYVE/PHD. DR Pfam; PF17981; ADD_ATRX; 1. DR Pfam; PF00271; Helicase_C; 1. DR Pfam; PF05064; Nsp1_C; 1. DR Pfam; PF00176; SNF2_N; 1. DR SMART; SM00487; DEXDc; 1. DR SMART; SM00490; HELICc; 1. DR SUPFAM; SSF52540; SSF52540; 2. DR SUPFAM; SSF57903; SSF57903; 1. DR PROSITE; PS51533; ADD; 1. DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1. DR PROSITE; PS51194; HELICASE_CTER; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW Chromosome {ECO:0000256|ARBA:ARBA00022895}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW DNA damage {ECO:0000256|ARBA:ARBA00022763}; KW DNA repair {ECO:0000256|ARBA:ARBA00023204}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Reference proteome {ECO:0000313|Proteomes:UP000319801}; KW Telomere {ECO:0000256|ARBA:ARBA00022895}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}. FT DOMAIN 540..678 FT /note="PHD-type" FT /evidence="ECO:0000259|PROSITE:PS51533" FT DOMAIN 1589..1776 FT /note="Helicase ATP-binding" FT /evidence="ECO:0000259|PROSITE:PS51192" FT DOMAIN 2025..2203 FT /note="Helicase C-terminal" FT /evidence="ECO:0000259|PROSITE:PS51194" FT REGION 144..192 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 445..489 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 507..537 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 677..704 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 798..851 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 868..1487 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1923..2000 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 252..272 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 331..351 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 764..791 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 1498..1528 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 2313..2333 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 163..187 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 473..489 FT /note="Acidic" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 508..537 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 824..841 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 887..901 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 928..958 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 978..1036 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1037..1051 FT /note="Acidic" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1122..1146 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1154..1189 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1214..1229 FT /note="Acidic" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1248..1262 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1265..1279 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1300..1324 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1355..1372 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1380..1398 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1408..1441 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1449..1464 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1948..1965 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 2466 AA; 273511 MW; 92CEDA0CE36997A7 CRC64; MSFSFGQAST GGGFSFGAPK TTASSTAAPG FSLQTSTPAS GGFTFAAPAQ QMPQNQAGTS QLAGLLAQTT TSAGAPQGGF SFGAAAAQNS TTGGGFSFGS ASKLTPASQP ATTAVTLGGL VTSAPSAAGT GFSFGGLVTQ PAASTQPSTG GFSFPGAKIQ PPAAPTVQST PSFSLGGQST ATPTPAGTAA PGQMAPLSSL FASPIPSAAS TGFSSTTSFS LGLKPAVSAA LSTVTSVPAA AAAASAAPVM TYAQLESLIN KWSSELEDQE RHFLQQATQV NAWDRMLVDN GEKQKELEDL LAPLEESVKE QSGTIYMQNA DEERERTYKL AENVDAQLKR MSQDLKEIIE HLNTSNRLAD TSDPNKLNLL HSGDAEISSA PYCKEMSTEN DRSSKLTALV TKLHEFLDHS EEETSAAQVD EISSGKMASN DSNINEELME KPGCSTEIPK ATSRSKRKPA VVTKHTAVNE PESADECEQD CTADDPNDTT IEMEEIPEDV VIVKPEPVSN EGKDEFKGPE FRNKGGSKVK EEGQRRRPDE HLQEIRCSRV NCTACGQQVN HFQRDSVYQH PILKVLLCKS CFKYYMSDDI SKDEDGMDEQ CRWCAEGGNL LCCDYCSNAF CKTCILRNLG RKELSGIMNN EDEKWHCYVC HPEPLEDHVA ACEKVLKNLE CMKKPKAEQD KPKRDGIKHK QSKVKNSALN GKDVNSDGSG TLTFSYKTLN VPKELLKKTK KLIETTNGLN STFVQFIQQE PVYLDENIVR HRHLKAFRSV LADLKKAHAT LEQALEEEFK ALEVVNGDGN GLADNPPVAV TVPDSEPAEQ SKDDQVVDQT VQDSTTDQVS AASEDEVDED EVNAVQADVE MAEDVVPAAE NPEEKLTENE ANAEVVQSKP DCEDDASAAG EASLDKDIVS IPPSVPDELF EMVESLSDCV KQESEKDSVD TDSMSSKNSE SDRKPKSGKR SAKVSKKLVV KLTPIPLKIT IKKDESKSKS QEKEGALSPD ESRRSPRMKT TPLRKSSERR SKSQSEDTRA NDDECDASET PVETGEPDSD SDEVPEVLRQ VEDEEATSDE PDAEPNGKEA GNTSPKKSAE QSSKKTAKRK LLASSSDSDN TKSRKAKNAA KKKRRESDSS NHDSDLEKEL KSLSRLRTTK KSKPGKKQTT EDEEEEEKEG KKTTKKKKEE ETKKEGKKGP KRSFERKRRS QKGKEKATKD SSSSSDDDDD EEEQEADSGE ESGDQQKIKP ILESALSHMD AFQQSSGDEA QVKAEPSQML DDDDDPENRC GYQMLLAQIK ANYSSGDDSS SEDDDSKTNK EERSPTKAKN DASSEGEEEE DSDSDSGSEV DVKKAGRRHK LLRKKLTLSE GESDTEKPAK SKKEVKRRGR RKAVNSDDSA DSDFKRSGSG SRSESAMSDF VSEDDEDNKS NKRKTRSSKK ADKDGERSYQ KEKKKKRRRI KVQDDSSSNK SAEEGDEDKE EEDEEGDDKG TPKGRKKIRK ILKDDKLRSE TQNALKEEEE RRRRIAEKER LREKLRETIV VEESSQITCP ITTKLVLDED EETKEPLVQV HRNMVTKLKP HQVDGVQFIW DCCCESVKKT KNSSGSGCIL AHCMGLGKTL QVVTFLHTVL LCEKLNFSTA LVVCPLNTVL NWLNEFEKWQ EGLKDEESLE VTELATVKRP QERAYALQRW QEDGGIMIIG YEMYRNLTQG RNIKSKKLKE TFQKTLVNPG PDFVICDEGH VLKNEASAVS KAMNSIKTRR RVILTGTPLQ NNLIEYHCMV NFIKENLLGS VKEFRNRFIN PIQNGQCADS TMVDVRVMKK RAHILYEMLA GCVQRRDYTA LTKFLPPKHE YVLAVRITPV QCKLYRYYLE HFTAGVGAAL EGGRGRAGTK LFQDFQMLSR IWTHPWCLQL DYISKENKGY FDEDSMDDFI ASETEESSMS LTSEDEKAKR KKKRGKGKGD SSDKSDSDDV EVIKEWNTSS RGGNPEGRNR AEPVEEVRAS SSGPGSPSPD WYKEFVTEAD AEILEHSGKI VLLFEILRMA EDVEDKVLVF SQSLISLDLI EDFLELAGRA KEEGKPSPYK GEGKWFKNID YYRLDGSTNA MTRKKWAEDF NDTSNVRGRL FLISTRAGSL GINLVAANRV IIFDASWNPS YDIQSIFRVY RFGQLKTVYV YRFLAQGTME EKIYDRQVTK QSLSFRVVDQ QQIERHFTMN ELTELYTFEP DQLDDPSEKK SKRSTPMLPK DPVLAELLHN FKDHIVGYHE HDSLLDHKEE EALSEEDRKA AWAEYEAEKK GLSMRINQPA YASVGIGSNY LPFNVAALAS MSNQQLEDLI NQGRQKVMEA TNALRTFPRE PLEDIISQVW KENPNLSESQ VQGMALARQA AIDMELKHRE ATYRDALNKQ QTLMMYVQKV INNRKVQEQQ LALARHGMLM NQMAMQNGIA GGMSQIDLLG LYQQLGALQG LPTSQIGKNP GPSKGL //