ID A0A510HVL9_THETH Unreviewed; 207 AA. AC A0A510HVL9; DT 16-OCT-2019, integrated into UniProtKB/TrEMBL. DT 16-OCT-2019, sequence version 1. DT 13-NOV-2019, entry version 2. DE RecName: Full=NADH-quinone oxidoreductase subunit C {ECO:0000256|HAMAP-Rule:MF_01357}; DE EC=7.1.1.- {ECO:0000256|HAMAP-Rule:MF_01357}; DE AltName: Full=NADH dehydrogenase I subunit C {ECO:0000256|HAMAP-Rule:MF_01357}; DE AltName: Full=NDH-1 subunit C {ECO:0000256|HAMAP-Rule:MF_01357}; GN Name=nqo5 {ECO:0000313|EMBL:BBL83841.1}; GN Synonyms=nuoC {ECO:0000256|HAMAP-Rule:MF_01357}; GN ORFNames=TthAA229_03220 {ECO:0000313|EMBL:BBL83841.1}; OS Thermus thermophilus. OC Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; OC Thermus. OX NCBI_TaxID=274 {ECO:0000313|EMBL:BBL83841.1, ECO:0000313|Proteomes:UP000320875}; RN [1] {ECO:0000313|EMBL:BBL83841.1, ECO:0000313|Proteomes:UP000320875} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AA2-29 {ECO:0000313|EMBL:BBL83841.1, RC ECO:0000313|Proteomes:UP000320875}; RA Miyazaki K., Tomariguchi N.; RT "Complete Genome Sequences of Thermus thermophilus Strains AA2-20 and RT AA2-29, Isolated from Arima Onsen in Japan."; RL Microbiol Resour Announc 8:e00820-19(2019). CC -!- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron- CC sulfur (Fe-S) centers, to quinones in the respiratory chain. The CC immediate electron acceptor for the enzyme in this species is CC believed to be a menaquinone. Couples the redox reaction to proton CC translocation (for every two electrons transferred, four hydrogen CC ions are translocated across the cytoplasmic membrane), and thus CC conserves the redox energy in a proton gradient. CC {ECO:0000256|HAMAP-Rule:MF_01357}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:57888, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:24646, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, CC ChEBI:CHEBI:132124; Evidence={ECO:0000256|HAMAP-Rule:MF_01357, CC ECO:0000256|RuleBase:RU003582}; CC -!- SUBUNIT: NDH-1 is composed of 15 different subunits. Subunits CC NuoB, C, D, E, F, and G constitute the peripheral sector of the CC complex. {ECO:0000256|HAMAP-Rule:MF_01357}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP- CC Rule:MF_01357}; Peripheral membrane protein {ECO:0000256|HAMAP- CC Rule:MF_01357}; Cytoplasmic side {ECO:0000256|HAMAP- CC Rule:MF_01357}. CC -!- SIMILARITY: Belongs to the complex I 30 kDa subunit family. CC {ECO:0000256|HAMAP-Rule:MF_01357, ECO:0000256|RuleBase:RU003456}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP019794; BBL83841.1; -; Genomic_DNA. DR Proteomes; UP000320875; Chromosome. DR Gene3D; 3.30.460.80; -; 1. DR HAMAP; MF_01357; NDH1_NuoC; 1. DR InterPro; IPR010218; NADH_DH_suC. DR InterPro; IPR037232; NADH_quin_OxRdtase_su_C/D-like. DR InterPro; IPR001268; NADH_UbQ_OxRdtase_30kDa_su. DR InterPro; IPR020396; NADH_UbQ_OxRdtase_CS. DR Pfam; PF00329; Complex1_30kDa; 1. DR SUPFAM; SSF143243; SSF143243; 1. DR TIGRFAMs; TIGR01961; NuoC_fam; 1. DR PROSITE; PS00542; COMPLEX1_30K; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01357}; KW Complete proteome {ECO:0000313|Proteomes:UP000320875}; KW Membrane {ECO:0000256|HAMAP-Rule:MF_01357}; KW NAD {ECO:0000256|HAMAP-Rule:MF_01357, ECO:0000256|RuleBase:RU003582}; KW Quinone {ECO:0000256|HAMAP-Rule:MF_01357, KW ECO:0000256|RuleBase:RU003582}; KW Translocase {ECO:0000256|HAMAP-Rule:MF_01357, KW ECO:0000256|RuleBase:RU003456}; KW Transport {ECO:0000256|HAMAP-Rule:MF_01357, KW ECO:0000256|RuleBase:RU003456}. FT DOMAIN 28 154 Complex1_30kDa. {ECO:0000259|Pfam: FT PF00329}. SQ SEQUENCE 207 AA; 23876 MW; E41990D49259437A CRC64; MRLERVLEEA RAKGYPIEDN GLGNLWVVLP KERFKEEMAH YKAMGFNFLA DIVGLDYLTY PERKPERFAV VYELVSLPGW KDGDGSRFFV RVYVPEEDPR LPTVTDLWGS ANFLEREVYD LFGIVFEGHP DLRKILTPED LEGHPLRKDY PLGETPTLFR EGRYIIPAEF RAALTGKDPG LTFYKGGSRK GYRSLWADLK KAREVKG //