ID A0A4Y6N8X3_SALET Unreviewed; 715 AA. AC A0A4Y6N8X3; DT 18-SEP-2019, integrated into UniProtKB/TrEMBL. DT 18-SEP-2019, sequence version 1. DT 12-AUG-2020, entry version 8. DE RecName: Full=Formate dehydrogenase {ECO:0000256|ARBA:ARBA00013128}; DE EC=1.17.1.9 {ECO:0000256|ARBA:ARBA00013128}; GN ORFNames=AU953_13270 {ECO:0000313|EMBL:ECY4440512.1}, AVC75_11535 GN {ECO:0000313|EMBL:ECY8106960.1}, D4X88_19235 GN {ECO:0000313|EMBL:EBS6379395.1}, D4Y88_20155 GN {ECO:0000313|EMBL:EBY4420025.1}, D5C30_19945 GN {ECO:0000313|EMBL:EBY6009245.1}, D6P78_19280 GN {ECO:0000313|EMBL:EBS1160261.1}, DQC01_11785 GN {ECO:0000313|EMBL:EBW7075619.1}, DTU12_20390 GN {ECO:0000313|EMBL:EBX8824982.1}, E0937_19745 GN {ECO:0000313|EMBL:ECD4555738.1}, E4471_19495 GN {ECO:0000313|EMBL:ECF4085293.1}, E6W89_19510 GN {ECO:0000313|EMBL:ECF4255840.1}, EFQ37_19985 GN {ECO:0000313|EMBL:EBZ7326507.1}, EGU88_20455 GN {ECO:0000313|EMBL:EBZ8334835.1}, EJG58_18700 GN {ECO:0000313|EMBL:ECA1869277.1}, EKA53_18805 GN {ECO:0000313|EMBL:ECA3616441.1}, EKP87_18330 GN {ECO:0000313|EMBL:ECA4300992.1}, EO191_19460 GN {ECO:0000313|EMBL:ECA7038335.1}, EO194_19010 GN {ECO:0000313|EMBL:ECA7156660.1}, EO209_19865 GN {ECO:0000313|EMBL:ECA7121145.1}, EO253_20400 GN {ECO:0000313|EMBL:ECA7102765.1}, EU820_21155 GN {ECO:0000313|EMBL:ECD0796247.1}, EUB91_19840 GN {ECO:0000313|EMBL:ECG2048135.1}, EUQ08_19995 GN {ECO:0000313|EMBL:ECA9801978.1}, EUV54_17385 GN {ECO:0000313|EMBL:ECE7577197.1}, EUV68_07635 GN {ECO:0000313|EMBL:ECE7708216.1}, EUV76_17970 GN {ECO:0000313|EMBL:ECB0585833.1}, EW960_18430 GN {ECO:0000313|EMBL:ECG3427947.1}, EWJ49_18785 GN {ECO:0000313|EMBL:ECE8992747.1}, EXA71_17770 GN {ECO:0000313|EMBL:ECD2605334.1}, EXP40_15795 GN {ECO:0000313|EMBL:ECG3813146.1}, EZW99_19935 GN {ECO:0000313|EMBL:ECF0318198.1}, FKX46_18800 GN {ECO:0000313|EMBL:ECD7845354.1}, FKX65_19460 GN {ECO:0000313|EMBL:ECG7439103.1}; OS Salmonella enterica subsp. enterica serovar Indiana. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Salmonella. OX NCBI_TaxID=286783 {ECO:0000313|EMBL:EBW7075619.1}; RN [1] {ECO:0000313|EMBL:EBW7075619.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=18608 {ECO:0000313|EMBL:ECY8106960.1}, 301673 RC {ECO:0000313|EMBL:EBX8824982.1}, 382836 RC {ECO:0000313|EMBL:EBW7075619.1}, 384955 RC {ECO:0000313|EMBL:ECG3813146.1}, 389622 RC {ECO:0000313|EMBL:ECD2605334.1}, 399309 RC {ECO:0000313|EMBL:ECG3427947.1}, 422505 RC {ECO:0000313|EMBL:EBS1160261.1}, 427416 RC {ECO:0000313|EMBL:ECE8992747.1}, 43915 RC {ECO:0000313|EMBL:ECY4440512.1}, 548529 RC {ECO:0000313|EMBL:ECD0796247.1}, 553265 RC {ECO:0000313|EMBL:ECB0585833.1}, 553765 RC {ECO:0000313|EMBL:ECE7708216.1}, 557258 RC {ECO:0000313|EMBL:ECE7577197.1}, 591925 RC {ECO:0000313|EMBL:ECA3616441.1}, 591927 RC {ECO:0000313|EMBL:EBY6009245.1}, 592633 RC {ECO:0000313|EMBL:ECA4300992.1}, 595623 RC {ECO:0000313|EMBL:EBY4420025.1}, 599586 RC {ECO:0000313|EMBL:EBS6379395.1, ECO:0000313|Proteomes:UP000336314}, RC 632961 {ECO:0000313|EMBL:EBZ7326507.1}, 636274 RC {ECO:0000313|EMBL:EBZ8334835.1}, 648993 RC {ECO:0000313|EMBL:ECA1869277.1}, 659352 RC {ECO:0000313|EMBL:ECA7038335.1}, 659381 RC {ECO:0000313|EMBL:ECA7156660.1}, 661039 RC {ECO:0000313|EMBL:ECA7102765.1}, 661045 RC {ECO:0000313|EMBL:ECA7121145.1}, 672565 RC {ECO:0000313|EMBL:ECG2048135.1}, 674070 RC {ECO:0000313|EMBL:ECA9801978.1}, 689094 RC {ECO:0000313|EMBL:ECF0318198.1}, 692652 RC {ECO:0000313|EMBL:ECD4555738.1}, 712512 RC {ECO:0000313|EMBL:ECF4085293.1}, 720657 RC {ECO:0000313|EMBL:ECF4255840.1}, 763020 RC {ECO:0000313|EMBL:ECG7439103.1}, and 763021 RC {ECO:0000313|EMBL:ECD7845354.1}; RA Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=formate + NAD(+) = CO2 + NADH; Xref=Rhea:RHEA:15985, CC ChEBI:CHEBI:15740, ChEBI:CHEBI:16526, ChEBI:CHEBI:57540, CC ChEBI:CHEBI:57945; EC=1.17.1.9; CC Evidence={ECO:0000256|ARBA:ARBA00000455}; CC -!- COFACTOR: CC Name=Mo-bis(molybdopterin guanine dinucleotide); CC Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942}; CC -!- COFACTOR: CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; CC Evidence={ECO:0000256|ARBA:ARBA00001966}; CC -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing CC oxidoreductase family. {ECO:0000256|ARBA:ARBA00010312}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:EBW7075619.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAGULP010000023; EBS1160261.1; -; Genomic_DNA. DR EMBL; AAGWDL010000022; EBS6379395.1; -; Genomic_DNA. DR EMBL; AAHJAA010000044; EBW7075619.1; -; Genomic_DNA. DR EMBL; AAHMMU010000027; EBX8824982.1; -; Genomic_DNA. DR EMBL; AAHOCL010000027; EBY4420025.1; -; Genomic_DNA. DR EMBL; AAHOMV010000023; EBY6009245.1; -; Genomic_DNA. DR EMBL; AAHSBS010000024; EBZ7326507.1; -; Genomic_DNA. DR EMBL; AAHSKH010000021; EBZ8334835.1; -; Genomic_DNA. DR EMBL; AAHTNR010000023; ECA1869277.1; -; Genomic_DNA. DR EMBL; AAHUCJ010000025; ECA3616441.1; -; Genomic_DNA. DR EMBL; AAHUIG010000022; ECA4300992.1; -; Genomic_DNA. DR EMBL; AAHVEP010000028; ECA7038335.1; -; Genomic_DNA. DR EMBL; AAHVGF010000025; ECA7102765.1; -; Genomic_DNA. DR EMBL; AAHVGA010000024; ECA7121145.1; -; Genomic_DNA. DR EMBL; AAHVFQ010000026; ECA7156660.1; -; Genomic_DNA. DR EMBL; AAHWCC010000025; ECA9801978.1; -; Genomic_DNA. DR EMBL; AAHWIV010000022; ECB0585833.1; -; Genomic_DNA. DR EMBL; AAIDOF010000032; ECD0796247.1; -; Genomic_DNA. DR EMBL; AAIEDH010000026; ECD2605334.1; -; Genomic_DNA. DR EMBL; AAIETN010000022; ECD4555738.1; -; Genomic_DNA. DR EMBL; AAIFVH010000027; ECD7845354.1; -; Genomic_DNA. DR EMBL; AAIIZG010000025; ECE7577197.1; -; Genomic_DNA. DR EMBL; AAIIZU010000014; ECE7708216.1; -; Genomic_DNA. DR EMBL; AAIJLD010000025; ECE8992747.1; -; Genomic_DNA. DR EMBL; AAIJWE010000026; ECF0318198.1; -; Genomic_DNA. DR EMBL; AAILBF010000028; ECF4085293.1; -; Genomic_DNA. DR EMBL; AAILDE010000026; ECF4255840.1; -; Genomic_DNA. DR EMBL; AAINPW010000040; ECG2048135.1; -; Genomic_DNA. DR EMBL; AAIOBK010000025; ECG3427947.1; -; Genomic_DNA. DR EMBL; AAIOEJ010000027; ECG3813146.1; -; Genomic_DNA. DR EMBL; AAIPJV010000024; ECG7439103.1; -; Genomic_DNA. DR EMBL; AALDGA010000023; ECY4440512.1; -; Genomic_DNA. DR EMBL; AALDPI010000023; ECY8106960.1; -; Genomic_DNA. DR Proteomes; UP000336314; Unassembled WGS sequence. DR GO; GO:0009326; C:formate dehydrogenase complex; IEA:UniProtKB-EC. DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. DR GO; GO:0008863; F:formate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro. DR GO; GO:0015942; P:formate metabolic process; IEA:InterPro. DR CDD; cd02790; MopB_CT_Formate-Dh_H; 1. DR CDD; cd02753; MopB_Formate-Dh-H; 1. DR InterPro; IPR009010; Asp_de-COase-like_dom_sf. DR InterPro; IPR041925; CT_Formate-Dh_H. DR InterPro; IPR041924; Formate_Dh-H_N. DR InterPro; IPR006478; Formate_DH_asu. DR InterPro; IPR006657; MoPterin_dinucl-bd_dom. DR InterPro; IPR006656; Mopterin_OxRdtase. DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom. DR InterPro; IPR006655; Mopterin_OxRdtase_prok_CS. DR InterPro; IPR027467; MopterinOxRdtase_cofactor_BS. DR Pfam; PF04879; Molybdop_Fe4S4; 1. DR Pfam; PF00384; Molybdopterin; 1. DR Pfam; PF01568; Molydop_binding; 1. DR SMART; SM00926; Molybdop_Fe4S4; 1. DR SUPFAM; SSF50692; SSF50692; 1. DR TIGRFAMs; TIGR01591; Fdh-alpha; 1. DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1. DR PROSITE; PS00551; MOLYBDOPTERIN_PROK_1; 1. DR PROSITE; PS00490; MOLYBDOPTERIN_PROK_2; 1. DR PROSITE; PS00932; MOLYBDOPTERIN_PROK_3; 1. PE 3: Inferred from homology; KW Iron {ECO:0000256|ARBA:ARBA00023004}; KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Molybdenum {ECO:0000256|ARBA:ARBA00022505}; KW NAD {ECO:0000256|ARBA:ARBA00023027}; KW Oxidoreductase {ECO:0000313|EMBL:EBW7075619.1}; KW Selenium {ECO:0000313|EMBL:EBW7075619.1}; KW Selenocysteine {ECO:0000313|EMBL:EBW7075619.1}. FT DOMAIN 1..56 FT /note="4Fe-4S Mo/W bis-MGD-type" FT /evidence="ECO:0000259|PROSITE:PS51669" FT NON_STD 140 FT /note="Selenocysteine" FT /evidence="ECO:0000313|EMBL:EBW7075619.1" SQ SEQUENCE 715 AA; 79212 MW; 159AF3532CF6B49F CRC64; MKKVVTVCPY CASGCKINLV VDNGKIVRAE AAQGKTNQGT LCLKGYYGWD FINDTQILTP RLKTPMIRRQ RGGKLESVSW DEALNYVAER LSAIKAKYGP DAIQTTGSSR GTGNETNYVM QKFARAVIGT NNVDCCARVU HGPSVAGLHQ SVGNGAMSNA INEIDNTDLV FVFGYNPADS HPIVANHVIN AKRNGAKIIV CDPRKIETAR IADMHIALKN GSNIALLNAM GHVIIEENLY DKAFVASRTE GFEEYSKIVE GYTPESVEEI TGVSAQEIRQ AARMYASAKS AAILWGMGVT QFYQGVETVR SLTSLAMLTG NLGKPSAGVN PVRGQNNVQG ACDMGALPDT YPGYQYVKFP ENREKFAKAW GVESLPAHTG YRISELPHRA AHGEVRAAYI MGEDPLQTDA ELSAVRKAFE DLELVIVQDI FMTKTASAAD VILPSTSWGE HEGVFSAADR GFQRFFKAVE PKWDLKTDWQ IISEIATRMG YPMHYNNTQE IWDELRHLCP DFYGATYEKM GELGYIQWPC RDTSDADQGT SYLFKEKFDT PNGLAQFFTC DWVAPIDKLT EEYPMVLSTV REVGHYSCRS MTGNCAALAA LADEPGYAQI NTADAARLGI EDEALVWVHS RKGKIITRAQ VSDRPNKGAI YMTYQWWIGA CNELVTENLS PITKTPEYKY CAVRVEPIAD QRAAEQYVID EYNKLKTRLR ESAMG //