ID   A0A4Y6N8X3_SALET        Unreviewed;       715 AA.
AC   A0A4Y6N8X3;
DT   18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 1.
DT   26-FEB-2020, entry version 5.
DE   SubName: Full=Formate dehydrogenase H subunit alpha, selenocysteine-containing {ECO:0000313|EMBL:QEO55783.1};
GN   ORFNames=AVC75_11535 {ECO:0000313|EMBL:ECY8106960.1}, AVE11_16230
GN   {ECO:0000313|EMBL:ECY5998326.1}, AVG34_16990
GN   {ECO:0000313|EMBL:ECY5714435.1}, E0937_19745
GN   {ECO:0000313|EMBL:ECD4555738.1}, E2L37_17335
GN   {ECO:0000313|EMBL:ECD6283712.1}, E2M10_21400
GN   {ECO:0000313|EMBL:ECD6229285.1}, E4471_19495
GN   {ECO:0000313|EMBL:ECF4085293.1}, E6W89_19510
GN   {ECO:0000313|EMBL:ECF4255840.1}, E6W90_19210
GN   {ECO:0000313|EMBL:ECF4287543.1}, EU820_21155
GN   {ECO:0000313|EMBL:ECD0796247.1}, EUB91_19840
GN   {ECO:0000313|EMBL:ECG2048135.1}, EUQ84_19550
GN   {ECO:0000313|EMBL:ECG2011630.1}, EUQ91_19350
GN   {ECO:0000313|EMBL:ECD0319191.1}, EUV54_17385
GN   {ECO:0000313|EMBL:ECE7577197.1}, EUV68_07635
GN   {ECO:0000313|EMBL:ECE7708216.1}, EW960_18430
GN   {ECO:0000313|EMBL:ECG3427947.1}, EWJ49_18785
GN   {ECO:0000313|EMBL:ECE8992747.1}, EX910_16955
GN   {ECO:0000313|EMBL:ECD3034855.1}, EXA71_17770
GN   {ECO:0000313|EMBL:ECD2605334.1}, EXP40_15795
GN   {ECO:0000313|EMBL:ECG3813146.1}, EZW99_19935
GN   {ECO:0000313|EMBL:ECF0318198.1}, FKX46_18800
GN   {ECO:0000313|EMBL:ECD7845354.1}, FKX65_19460
GN   {ECO:0000313|EMBL:ECG7439103.1}, FOL37_22335
GN   {ECO:0000313|EMBL:QEM66174.1}, FV315_20980
GN   {ECO:0000313|EMBL:QEO55783.1};
OS   Salmonella enterica subsp. enterica serovar Indiana.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=286783 {ECO:0000313|EMBL:QEO55783.1};
RN   [1] {ECO:0000313|EMBL:ECD7845354.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=129491 {ECO:0000313|EMBL:ECD6229285.1}, 131501
RC   {ECO:0000313|EMBL:ECD6283712.1}, 18608
RC   {ECO:0000313|EMBL:ECY8106960.1}, 384955
RC   {ECO:0000313|EMBL:ECG3813146.1}, 388735
RC   {ECO:0000313|EMBL:ECD3034855.1}, 389622
RC   {ECO:0000313|EMBL:ECD2605334.1}, 399309
RC   {ECO:0000313|EMBL:ECG3427947.1}, 427416
RC   {ECO:0000313|EMBL:ECE8992747.1}, 43955
RC   {ECO:0000313|EMBL:ECY5998326.1}, 548529
RC   {ECO:0000313|EMBL:ECD0796247.1}, 553765
RC   {ECO:0000313|EMBL:ECE7708216.1}, 557258
RC   {ECO:0000313|EMBL:ECE7577197.1}, 56955
RC   {ECO:0000313|EMBL:ECY5714435.1}, 582241
RC   {ECO:0000313|EMBL:ECG2011630.1}, 609461
RC   {ECO:0000313|EMBL:ECD0319191.1}, 672565
RC   {ECO:0000313|EMBL:ECG2048135.1}, 689094
RC   {ECO:0000313|EMBL:ECF0318198.1}, 692652
RC   {ECO:0000313|EMBL:ECD4555738.1}, 712512
RC   {ECO:0000313|EMBL:ECF4085293.1}, 720656
RC   {ECO:0000313|EMBL:ECF4287543.1}, 720657
RC   {ECO:0000313|EMBL:ECF4255840.1}, 763020
RC   {ECO:0000313|EMBL:ECG7439103.1}, and 763021
RC   {ECO:0000313|EMBL:ECD7845354.1};
RA   Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL   Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:QEM66174.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FJC33 {ECO:0000313|EMBL:QEM66174.1};
RA   Fang L.;
RT   "Co-spread of plasmid-mediated and chromosomally encoded fosA3 gene with
RT   multiple important ARGs among Multi-Drug Resistant Salmonella from food
RT   animals.";
RL   Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:QEO55783.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=K16SI097 {ECO:0000313|EMBL:QEO55783.1};
RA   Moon D., Lim S.-K.;
RL   Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mo-bis(molybdopterin guanine dinucleotide);
CC         Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|SAAS:SAAS00648551};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|SAAS:SAAS00607242};
CC   -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC       oxidoreductase family. {ECO:0000256|SAAS:SAAS01108232}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAIDKC010000023; ECD0319191.1; -; Genomic_DNA.
DR   EMBL; AAIDOF010000032; ECD0796247.1; -; Genomic_DNA.
DR   EMBL; AAIEDH010000026; ECD2605334.1; -; Genomic_DNA.
DR   EMBL; AAIEGR010000024; ECD3034855.1; -; Genomic_DNA.
DR   EMBL; AAIETN010000022; ECD4555738.1; -; Genomic_DNA.
DR   EMBL; AAIFHQ010000043; ECD6229285.1; -; Genomic_DNA.
DR   EMBL; AAIFIB010000024; ECD6283712.1; -; Genomic_DNA.
DR   EMBL; AAIFVH010000027; ECD7845354.1; -; Genomic_DNA.
DR   EMBL; AAIIZG010000025; ECE7577197.1; -; Genomic_DNA.
DR   EMBL; AAIIZU010000014; ECE7708216.1; -; Genomic_DNA.
DR   EMBL; AAIJLD010000025; ECE8992747.1; -; Genomic_DNA.
DR   EMBL; AAIJWE010000026; ECF0318198.1; -; Genomic_DNA.
DR   EMBL; AAILBF010000028; ECF4085293.1; -; Genomic_DNA.
DR   EMBL; AAILDE010000026; ECF4255840.1; -; Genomic_DNA.
DR   EMBL; AAILDM010000023; ECF4287543.1; -; Genomic_DNA.
DR   EMBL; AAINPO010000024; ECG2011630.1; -; Genomic_DNA.
DR   EMBL; AAINPW010000040; ECG2048135.1; -; Genomic_DNA.
DR   EMBL; AAIOBK010000025; ECG3427947.1; -; Genomic_DNA.
DR   EMBL; AAIOEJ010000027; ECG3813146.1; -; Genomic_DNA.
DR   EMBL; AAIPJV010000024; ECG7439103.1; -; Genomic_DNA.
DR   EMBL; AALDZP010000029; ECY5714435.1; -; Genomic_DNA.
DR   EMBL; AALDTA010000022; ECY5998326.1; -; Genomic_DNA.
DR   EMBL; AALDPI010000023; ECY8106960.1; -; Genomic_DNA.
DR   EMBL; CP041699; QEM66174.1; -; Genomic_DNA.
DR   EMBL; CP043564; QEO55783.1; -; Genomic_DNA.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0008863; F:formate dehydrogenase (NAD+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR   GO; GO:0015942; P:formate metabolic process; IEA:InterPro.
DR   CDD; cd02790; MopB_CT_Formate-Dh_H; 1.
DR   CDD; cd02753; MopB_Formate-Dh-H; 1.
DR   InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR   InterPro; IPR041925; CT_Formate-Dh_H.
DR   InterPro; IPR041924; Formate_Dh-H_N.
DR   InterPro; IPR006478; Formate_DH_asu.
DR   InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR   InterPro; IPR006656; Mopterin_OxRdtase.
DR   InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR   InterPro; IPR006655; Mopterin_OxRdtase_prok_CS.
DR   InterPro; IPR027467; MopterinOxRdtase_cofactor_BS.
DR   Pfam; PF04879; Molybdop_Fe4S4; 1.
DR   Pfam; PF00384; Molybdopterin; 1.
DR   Pfam; PF01568; Molydop_binding; 1.
DR   SMART; SM00926; Molybdop_Fe4S4; 1.
DR   SUPFAM; SSF50692; SSF50692; 1.
DR   TIGRFAMs; TIGR01591; Fdh-alpha; 1.
DR   PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR   PROSITE; PS00551; MOLYBDOPTERIN_PROK_1; 1.
DR   PROSITE; PS00490; MOLYBDOPTERIN_PROK_2; 1.
DR   PROSITE; PS00932; MOLYBDOPTERIN_PROK_3; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|SAAS:SAAS00418020};
KW   Iron {ECO:0000256|SAAS:SAAS00454562};
KW   Iron-sulfur {ECO:0000256|SAAS:SAAS00454505};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00077323};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS01133048};
KW   Selenium {ECO:0000313|EMBL:QEO55783.1};
KW   Selenocysteine {ECO:0000313|EMBL:QEO55783.1}.
FT   DOMAIN          1..56
FT                   /note="4Fe-4S Mo/W bis-MGD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51669"
FT   NON_STD         140
FT                   /note="Selenocysteine"
FT                   /evidence="ECO:0000313|EMBL:QEO55783.1"
SQ   SEQUENCE   715 AA;  79212 MW;  159AF3532CF6B49F CRC64;
     MKKVVTVCPY CASGCKINLV VDNGKIVRAE AAQGKTNQGT LCLKGYYGWD FINDTQILTP
     RLKTPMIRRQ RGGKLESVSW DEALNYVAER LSAIKAKYGP DAIQTTGSSR GTGNETNYVM
     QKFARAVIGT NNVDCCARVU HGPSVAGLHQ SVGNGAMSNA INEIDNTDLV FVFGYNPADS
     HPIVANHVIN AKRNGAKIIV CDPRKIETAR IADMHIALKN GSNIALLNAM GHVIIEENLY
     DKAFVASRTE GFEEYSKIVE GYTPESVEEI TGVSAQEIRQ AARMYASAKS AAILWGMGVT
     QFYQGVETVR SLTSLAMLTG NLGKPSAGVN PVRGQNNVQG ACDMGALPDT YPGYQYVKFP
     ENREKFAKAW GVESLPAHTG YRISELPHRA AHGEVRAAYI MGEDPLQTDA ELSAVRKAFE
     DLELVIVQDI FMTKTASAAD VILPSTSWGE HEGVFSAADR GFQRFFKAVE PKWDLKTDWQ
     IISEIATRMG YPMHYNNTQE IWDELRHLCP DFYGATYEKM GELGYIQWPC RDTSDADQGT
     SYLFKEKFDT PNGLAQFFTC DWVAPIDKLT EEYPMVLSTV REVGHYSCRS MTGNCAALAA
     LADEPGYAQI NTADAARLGI EDEALVWVHS RKGKIITRAQ VSDRPNKGAI YMTYQWWIGA
     CNELVTENLS PITKTPEYKY CAVRVEPIAD QRAAEQYVID EYNKLKTRLR ESAMG
//