ID   A0A4Y6N8X3_SALET        Unreviewed;       715 AA.
AC   A0A4Y6N8X3;
DT   18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 1.
DT   03-AUG-2022, entry version 17.
DE   SubName: Full=Formate dehydrogenase H subunit alpha, selenocysteine-containing {ECO:0000313|EMBL:EBW7075619.1};
DE            EC=1.17.1.9 {ECO:0000313|EMBL:EBW7075619.1};
GN   ORFNames=CAC52_20155 {ECO:0000313|EMBL:QVQ16714.1}, D4X88_19235
GN   {ECO:0000313|EMBL:EBS6379395.1}, DQC01_11785
GN   {ECO:0000313|EMBL:EBW7075619.1}, EGU88_20455
GN   {ECO:0000313|EMBL:EBZ8334835.1}, EO194_19010
GN   {ECO:0000313|EMBL:ECA7156660.1}, EO253_20400
GN   {ECO:0000313|EMBL:ECA7102765.1}, EUV76_17970
GN   {ECO:0000313|EMBL:ECB0585833.1}, GNC04_003811
GN   {ECO:0000313|EMBL:HAE3817943.1};
OS   Salmonella enterica subsp. enterica serovar Indiana.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=286783 {ECO:0000313|EMBL:EBW7075619.1};
RN   [1] {ECO:0000313|EMBL:HAE3817943.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DMS 3702 {ECO:0000313|EMBL:HAE3817943.1};
RX   PubMed=30286803;
RA   Souvorov A., Agarwala R., Lipman D.J.;
RT   "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL   Genome Biol. 19:153-150(2018).
RN   [2] {ECO:0000313|EMBL:EBW7075619.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=382836 {ECO:0000313|EMBL:EBW7075619.1}, 553265
RC   {ECO:0000313|EMBL:ECB0585833.1}, 599586
RC   {ECO:0000313|EMBL:EBS6379395.1, ECO:0000313|Proteomes:UP000336314},
RC   636274 {ECO:0000313|EMBL:EBZ8334835.1}, 659381
RC   {ECO:0000313|EMBL:ECA7156660.1}, and 661039
RC   {ECO:0000313|EMBL:ECA7102765.1};
RA   Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:HAE3817943.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DMS 3702 {ECO:0000313|EMBL:HAE3817943.1};
RG   NCBI Pathogen Detection Project;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:QVQ16714.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SGSC 2482 {ECO:0000313|EMBL:QVQ16714.1};
RG   GenomeTrakr network: Whole genome sequencing for foodborne pathogen traceback;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:QVQ16714.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SGSC 2482 {ECO:0000313|EMBL:QVQ16714.1};
RA   Hoffmann M., Balkey M., Luo Y.;
RT   "Whole genome PacBio Sequel sequence of Salmonella enterica subsp.
RT   enterica.";
RL   Submitted (MAY-2021) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mo-bis(molybdopterin guanine dinucleotide);
CC         Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC       oxidoreductase family. {ECO:0000256|ARBA:ARBA00010312}.
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DR   EMBL; AAGWDL010000022; EBS6379395.1; -; Genomic_DNA.
DR   EMBL; AAHJAA010000044; EBW7075619.1; -; Genomic_DNA.
DR   EMBL; AAHSKH010000021; EBZ8334835.1; -; Genomic_DNA.
DR   EMBL; AAHVGF010000025; ECA7102765.1; -; Genomic_DNA.
DR   EMBL; AAHVFQ010000026; ECA7156660.1; -; Genomic_DNA.
DR   EMBL; AAHWIV010000022; ECB0585833.1; -; Genomic_DNA.
DR   EMBL; DAARSZ010000025; HAE3817943.1; -; Genomic_DNA.
DR   EMBL; CP074612; QVQ16714.1; -; Genomic_DNA.
DR   Proteomes; UP000336314; Unassembled WGS sequence.
DR   GO; GO:0009326; C:formate dehydrogenase complex; IEA:UniProtKB-EC.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008863; F:formate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR   GO; GO:0015942; P:formate metabolic process; IEA:InterPro.
DR   CDD; cd02790; MopB_CT_Formate-Dh_H; 1.
DR   CDD; cd02753; MopB_Formate-Dh-H; 1.
DR   InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR   InterPro; IPR041925; CT_Formate-Dh_H.
DR   InterPro; IPR041924; Formate_Dh-H_N.
DR   InterPro; IPR006478; Formate_DH_asu.
DR   InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR   InterPro; IPR006656; Mopterin_OxRdtase.
DR   InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR   InterPro; IPR006655; Mopterin_OxRdtase_prok_CS.
DR   InterPro; IPR027467; MopterinOxRdtase_cofactor_BS.
DR   Pfam; PF04879; Molybdop_Fe4S4; 1.
DR   Pfam; PF00384; Molybdopterin; 1.
DR   Pfam; PF01568; Molydop_binding; 1.
DR   SMART; SM00926; Molybdop_Fe4S4; 1.
DR   SUPFAM; SSF50692; SSF50692; 1.
DR   TIGRFAMs; TIGR01591; Fdh-alpha; 1.
DR   PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR   PROSITE; PS00551; MOLYBDOPTERIN_PROK_1; 1.
DR   PROSITE; PS00490; MOLYBDOPTERIN_PROK_2; 1.
DR   PROSITE; PS00932; MOLYBDOPTERIN_PROK_3; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|PROSITE-ProRule:PRU01004};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PROSITE-ProRule:PRU01004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|PROSITE-
KW   ProRule:PRU01004};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU01004}; Molybdenum {ECO:0000256|ARBA:ARBA00022505};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000313|EMBL:EBW7075619.1};
KW   Selenium {ECO:0000313|EMBL:EBW7075619.1};
KW   Selenocysteine {ECO:0000313|EMBL:EBW7075619.1}.
FT   DOMAIN          1..56
FT                   /note="4Fe-4S Mo/W bis-MGD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51669"
FT   BINDING         8
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01004"
FT   BINDING         11
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01004"
FT   BINDING         15
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01004"
FT   BINDING         42
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01004"
FT   NON_STD         140
FT                   /note="Selenocysteine"
FT                   /evidence="ECO:0000313|EMBL:EBW7075619.1"
SQ   SEQUENCE   715 AA;  79212 MW;  159AF3532CF6B49F CRC64;
     MKKVVTVCPY CASGCKINLV VDNGKIVRAE AAQGKTNQGT LCLKGYYGWD FINDTQILTP
     RLKTPMIRRQ RGGKLESVSW DEALNYVAER LSAIKAKYGP DAIQTTGSSR GTGNETNYVM
     QKFARAVIGT NNVDCCARVU HGPSVAGLHQ SVGNGAMSNA INEIDNTDLV FVFGYNPADS
     HPIVANHVIN AKRNGAKIIV CDPRKIETAR IADMHIALKN GSNIALLNAM GHVIIEENLY
     DKAFVASRTE GFEEYSKIVE GYTPESVEEI TGVSAQEIRQ AARMYASAKS AAILWGMGVT
     QFYQGVETVR SLTSLAMLTG NLGKPSAGVN PVRGQNNVQG ACDMGALPDT YPGYQYVKFP
     ENREKFAKAW GVESLPAHTG YRISELPHRA AHGEVRAAYI MGEDPLQTDA ELSAVRKAFE
     DLELVIVQDI FMTKTASAAD VILPSTSWGE HEGVFSAADR GFQRFFKAVE PKWDLKTDWQ
     IISEIATRMG YPMHYNNTQE IWDELRHLCP DFYGATYEKM GELGYIQWPC RDTSDADQGT
     SYLFKEKFDT PNGLAQFFTC DWVAPIDKLT EEYPMVLSTV REVGHYSCRS MTGNCAALAA
     LADEPGYAQI NTADAARLGI EDEALVWVHS RKGKIITRAQ VSDRPNKGAI YMTYQWWIGA
     CNELVTENLS PITKTPEYKY CAVRVEPIAD QRAAEQYVID EYNKLKTRLR ESAMG
//