ID A0A4X1VKC6_PIG Unreviewed; 463 AA. AC A0A4X1VKC6; DT 18-SEP-2019, integrated into UniProtKB/TrEMBL. DT 18-SEP-2019, sequence version 1. DT 02-OCT-2024, entry version 25. DE RecName: Full=NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial {ECO:0000256|ARBA:ARBA00020178}; DE AltName: Full=Complex I-49kD {ECO:0000256|ARBA:ARBA00030505}; DE AltName: Full=NADH-ubiquinone oxidoreductase 49 kDa subunit {ECO:0000256|ARBA:ARBA00031562}; GN Name=NDUFS2 {ECO:0000313|Ensembl:ENSSSCP00070043947.1}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00070043947.1, ECO:0000313|Proteomes:UP000314985}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00070043947.1, ECO:0000313|Proteomes:UP000314985} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Hannum G.I., Koren S., Schroeder S.G., Chin S.C., Nonneman D.J., RA Becker S.A., Rosen B.D., Bickhart D.M., Putnam N.H., Green R.E., RA Tuggle C.K., Liu H., Rohrer G.A., Warr A., Hall R., Kim K., Hume D.A., RA Talbot R., Chow W., Howe K., Schwartz A.S., Watson M., Archibald A.L., RA Phillippy A.M., Smith T.P.L.; RT "USMARCv1.0."; RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0007829|PDB:7VBP, ECO:0007829|PDB:7VWL} RP STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS) OF 34-73. RX PubMed=35145322; DOI=10.1038/s41594-022-00722-w; RA Gu J., Liu T., Guo R., Zhang L., Yang M.; RT "The coupling mechanism of mammalian mitochondrial complex I."; RL Nat. Struct. Mol. Biol. 29:172-182(2022). RN [3] {ECO:0000313|Ensembl:ENSSSCP00070043947.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2023) to UniProtKB. CC -!- COFACTOR: CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; CC Evidence={ECO:0000256|ARBA:ARBA00001966}; CC -!- SIMILARITY: Belongs to the complex I 49 kDa subunit family. CC {ECO:0000256|ARBA:ARBA00005769, ECO:0000256|RuleBase:RU003685}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_005663224.1; XM_005663167.2. DR PDB; 7VBP; EM; 2.80 A; Q=34-73. DR PDB; 7VWL; EM; 2.70 A; Q=34-73. DR PDB; 7VYI; EM; 3.10 A; Q=34-73. DR AlphaFoldDB; A0A4X1VKC6; -. DR EMDB; EMD-31884; -. DR EMDB; EMD-32155; -. DR EMDB; EMD-32206; -. DR SMR; A0A4X1VKC6; -. DR Ensembl; ENSSSCT00070051938.1; ENSSSCP00070043947.1; ENSSSCG00070025949.1. DR GeneID; 100156075; -. DR CTD; 4720; -. DR OrthoDB; 191at2759; -. DR Proteomes; UP000314985; Chromosome 4. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. DR GO; GO:0051287; F:NAD binding; IEA:InterPro. DR GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:InterPro. DR GO; GO:0048038; F:quinone binding; IEA:InterPro. DR Gene3D; 1.10.645.10; Cytochrome-c3 Hydrogenase, chain B; 1. DR HAMAP; MF_01358; NDH1_NuoD; 1. DR InterPro; IPR001135; NADH_Q_OxRdtase_suD. DR InterPro; IPR014029; NADH_UbQ_OxRdtase_49kDa_CS. DR InterPro; IPR022885; NDH1_su_D/H. DR InterPro; IPR029014; NiFe-Hase_large. DR NCBIfam; TIGR01962; NuoD; 1. DR PANTHER; PTHR11993:SF10; NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL; 1. DR PANTHER; PTHR11993; NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT; 1. DR Pfam; PF00346; Complex1_49kDa; 1. DR SUPFAM; SSF56762; HydB/Nqo4-like; 1. DR PROSITE; PS00535; COMPLEX1_49K; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:7VBP, ECO:0007829|PDB:7VWL}; KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485}; KW Electron transport {ECO:0000256|ARBA:ARBA00022982}; KW Iron {ECO:0000256|ARBA:ARBA00022485}; KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022485}; KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU003685}; KW Respiratory chain {ECO:0000256|ARBA:ARBA00022660}; KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU003685}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003685}. FT DOMAIN 193..463 FT /note="NADH-quinone oxidoreductase subunit D" FT /evidence="ECO:0000259|Pfam:PF00346" SQ SEQUENCE 463 AA; 52486 MW; 3649090E7B2BA586 CRC64; MAALRALCSL RGVAAQVLRP GAGARLPIQP SRGARQWQPD VEWAEQFGGA VMYPTKETAH WKPPPWNDVD PPKDTLVSNL TLNFGPQHPA AHGVLRLVME LSGEMVRKCD PHIGLLHRGT EKLIEYKTYL QALPYFDRLD YVSMMCNEQA YSLAVEKLLN IQPPPRAQWI RVLFGEITRL LNHIMAVTTH ALDIGAMTPF FWMFEEREKM FEFYERVSGA RMHAAYIRPG GVHQDLPLGL LDDIYEFSKN FSFRIDELEE MLTNNRIWRN RTVDIGVVTA EDALNYGFSG VMLRGSGIQW DLRKTQPYDV YDQVEFDVPI GSRGDCYDRY LCRVEEMRQS LRIISQCLNK MPPGEIKVDD AKVSPPKRAE MKTSMESLIH HFKLYTEGYQ VPPGATYTAI EAPKGEFGVY LVSDGSSRPY RCKIKAPGFA HLAGLDKMSK GHMLADVVAI IGTQDIVFGE VDR //