ID A0A4X1VKC6_PIG Unreviewed; 463 AA. AC A0A4X1VKC6; DT 18-SEP-2019, integrated into UniProtKB/TrEMBL. DT 18-SEP-2019, sequence version 1. DT 02-JUN-2021, entry version 10. DE RecName: Full=Complex I-49kD {ECO:0000256|ARBA:ARBA00021272}; DE AltName: Full=NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial {ECO:0000256|ARBA:ARBA00020178}; DE AltName: Full=NADH-ubiquinone oxidoreductase 49 kDa subunit {ECO:0000256|ARBA:ARBA00015533}; GN Name=NDUFS2 {ECO:0000313|Ensembl:ENSSSCP00070043947}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00070043947, ECO:0000313|Proteomes:UP000314985}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00070043947, ECO:0000313|Proteomes:UP000314985} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Hannum G.I., Koren S., Schroeder S.G., Chin S.C., Nonneman D.J., RA Becker S.A., Rosen B.D., Bickhart D.M., Putnam N.H., Green R.E., RA Tuggle C.K., Liu H., Rohrer G.A., Warr A., Hall R., Kim K., Hume D.A., RA Talbot R., Chow W., Howe K., Schwartz A.S., Watson M., Archibald A.L., RA Phillippy A.M., Smith T.P.L.; RT "USMARCv1.0."; RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00070043947} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2019) to UniProtKB. CC -!- COFACTOR: CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; CC Evidence={ECO:0000256|ARBA:ARBA00001966}; CC -!- SIMILARITY: Belongs to the complex I 49 kDa subunit family. CC {ECO:0000256|ARBA:ARBA00005769, ECO:0000256|RuleBase:RU003685}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_005663224.1; XM_005663167.2. DR SMR; A0A4X1VKC6; -. DR Ensembl; ENSSSCT00070051938; ENSSSCP00070043947; ENSSSCG00070025949. DR GeneID; 100156075; -. DR CTD; 4720; -. DR OMA; IMGTSME; -. DR Proteomes; UP000314985; Chromosome 4. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. DR GO; GO:0051287; F:NAD binding; IEA:InterPro. DR GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:InterPro. DR GO; GO:0048038; F:quinone binding; IEA:InterPro. DR Gene3D; 1.10.645.20; -; 1. DR HAMAP; MF_01358; NDH1_NuoD; 1. DR InterPro; IPR001135; NADH_Q_OxRdtase_suD. DR InterPro; IPR038290; NADH_Q_OxRdtase_suD_sf. DR InterPro; IPR014029; NADH_UbQ_OxRdtase_49kDa_CS. DR InterPro; IPR022885; NDH1_su_D/H. DR InterPro; IPR029014; NiFe-Hase_large. DR Pfam; PF00346; Complex1_49kDa; 1. DR SUPFAM; SSF56762; SSF56762; 1. DR TIGRFAMs; TIGR01962; NuoD; 1. DR PROSITE; PS00535; COMPLEX1_49K; 1. PE 3: Inferred from homology; KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485}; KW Electron transport {ECO:0000256|ARBA:ARBA00022982}; KW Iron {ECO:0000256|ARBA:ARBA00022485}; KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022485}; KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU003685}; KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}; KW Respiratory chain {ECO:0000256|ARBA:ARBA00022660}; KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU003685}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003685}. FT DOMAIN 193..463 FT /note="Complex1_49kDa" FT /evidence="ECO:0000259|Pfam:PF00346" SQ SEQUENCE 463 AA; 52486 MW; 3649090E7B2BA586 CRC64; MAALRALCSL RGVAAQVLRP GAGARLPIQP SRGARQWQPD VEWAEQFGGA VMYPTKETAH WKPPPWNDVD PPKDTLVSNL TLNFGPQHPA AHGVLRLVME LSGEMVRKCD PHIGLLHRGT EKLIEYKTYL QALPYFDRLD YVSMMCNEQA YSLAVEKLLN IQPPPRAQWI RVLFGEITRL LNHIMAVTTH ALDIGAMTPF FWMFEEREKM FEFYERVSGA RMHAAYIRPG GVHQDLPLGL LDDIYEFSKN FSFRIDELEE MLTNNRIWRN RTVDIGVVTA EDALNYGFSG VMLRGSGIQW DLRKTQPYDV YDQVEFDVPI GSRGDCYDRY LCRVEEMRQS LRIISQCLNK MPPGEIKVDD AKVSPPKRAE MKTSMESLIH HFKLYTEGYQ VPPGATYTAI EAPKGEFGVY LVSDGSSRPY RCKIKAPGFA HLAGLDKMSK GHMLADVVAI IGTQDIVFGE VDR //