ID A0A4W5L9E2_9TELE Unreviewed; 986 AA. AC A0A4W5L9E2; DT 18-SEP-2019, integrated into UniProtKB/TrEMBL. DT 18-SEP-2019, sequence version 1. DT 03-MAY-2023, entry version 11. DE SubName: Full=Pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 {ECO:0000313|Ensembl:ENSHHUP00000022405.1}; OS Hucho hucho (huchen). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes; OC Salmonidae; Salmoninae; Hucho. OX NCBI_TaxID=62062 {ECO:0000313|Ensembl:ENSHHUP00000022405.1, ECO:0000313|Proteomes:UP000314982}; RN [1] {ECO:0000313|Proteomes:UP000314982} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Macqueen D.J., Gundappa M.K.; RT "Genome assembly of Danube salmon."; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSHHUP00000022405.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A4W5L9E2; -. DR Ensembl; ENSHHUT00000023255.1; ENSHHUP00000022405.1; ENSHHUG00000013923.1. DR GeneTree; ENSGT00940000159456; -. DR Proteomes; UP000314982; Unassembled WGS sequence. DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro. DR CDD; cd14473; FERM_B-lobe; 1. DR CDD; cd00821; PH; 1. DR CDD; cd13282; PH1_PLEKHH1_PLEKHH2; 1. DR Gene3D; 1.20.80.10; -; 1. DR Gene3D; 1.25.40.530; MyTH4 domain; 1. DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2. DR InterPro; IPR019749; Band_41_domain. DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf. DR InterPro; IPR035963; FERM_2. DR InterPro; IPR019748; FERM_central. DR InterPro; IPR000299; FERM_domain. DR InterPro; IPR000857; MyTH4_dom. DR InterPro; IPR038185; MyTH4_dom_sf. DR InterPro; IPR011993; PH-like_dom_sf. DR InterPro; IPR001849; PH_domain. DR PANTHER; PTHR22903:SF4; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 1; 1. DR PANTHER; PTHR22903; PLEKHH PROTEIN; 1. DR Pfam; PF00373; FERM_M; 1. DR Pfam; PF00784; MyTH4; 1. DR Pfam; PF00169; PH; 1. DR SMART; SM00295; B41; 1. DR SMART; SM00139; MyTH4; 1. DR SMART; SM00233; PH; 2. DR SUPFAM; SSF50729; PH domain-like; 2. DR SUPFAM; SSF47031; Second domain of FERM; 1. DR PROSITE; PS50057; FERM_3; 1. DR PROSITE; PS51016; MYTH4; 1. DR PROSITE; PS50003; PH_DOMAIN; 2. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Reference proteome {ECO:0000313|Proteomes:UP000314982}. FT DOMAIN 229..323 FT /note="PH" FT /evidence="ECO:0000259|PROSITE:PS50003" FT DOMAIN 338..446 FT /note="PH" FT /evidence="ECO:0000259|PROSITE:PS50003" FT DOMAIN 483..637 FT /note="MyTH4" FT /evidence="ECO:0000259|PROSITE:PS51016" FT DOMAIN 648..986 FT /note="FERM" FT /evidence="ECO:0000259|PROSITE:PS50057" FT REGION 137..182 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 198..219 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 1..67 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 151..168 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 986 AA; 112027 MW; EF77D359EE6A17A9 CRC64; MQELELRVTE SDQRAESAEK QIHVMEEKLK SANVQPSKSE NSVYRRYQDL TNQVQEKDAV IKRLEVQLEK QILVRAQEAK IIEEKAAKIK DWVTFKLREV RSGLPLYPAA GPFTHLIYKN ITVPVYTTLK GKATQISSEP LHDDDSGSED DSGSLASLRT STLGPERKGS TPGSPRAVKR GVSMSSISSE SDYAIPPDAY SLESDYSEPE HKVQRTSSYS CESLREPEML EKSGYLLKMG SQVKAWKRRW FILRNGEIFY YKSPSDVIRK PQGQVELNSS CRIARGEGAQ TFQLITEKKT FFLTADSPNI LEEWIRVLQN IFKVQASSPV TMETTTAKPT MRGWLTKVKH GHSKLVWCSL VSKVFYYYRN QDDKLPLGQL RMREVVVEEV DRSCDSDEDY EASGRGFLSS HCTLVVHPRE QSPTYLLIGT KQEKDTWLYH LTVAAGSSAS FKVGTEYEQL VGNLLDIEGD PDSALWRSEA LCFCKDGLRS PLTTLPSEAL QTEALKLFKS CQLFINVLVE SPSIDYHMSL AQNALQVCLT HPELQNEMYC QLIKQTNRRT PHNSSLTQCW QLLAVCVALF LPQQHFLWYL RQYLQRHADP RSEVGKYAVY CQRSVERTLQ NGEREAKPSR MEILSILLRN PYHHSLPFSI PVHFKNVTYQ VVGFDGSTTV EEFLSTLTQR VGMRKPHLSG FALFTDDPSG RDLEHCLQPS VKICDVISKW EQALKELHPG KYEGTRIVRL MYKSRLCFRA QAKGETERER LLLTYQVNDE VHQGHFPVNK ELALEVAALM AQVEHGDLDR PAPSSSASCS SPQPNTQQIL LQALGRFYPK RYKQDCSMDQ LRDLSERLAT KWSVLSGCSA SECVRIYLTV ARKWPLFGAK LFHAKVSGNG TRLKNLSSFP ESHLLVTYSY QSVITFGGCR DDLMVVVSQT NEQGGGKKSV EKLVFALPKP KVKKVTLISA FYFLYLKKQT KKKQFLLCHY GVLCID //