ID A0A4W4G278_ELEEL Unreviewed; 322 AA. AC A0A4W4G278; DT 18-SEP-2019, integrated into UniProtKB/TrEMBL. DT 18-SEP-2019, sequence version 1. DT 29-MAY-2024, entry version 19. DE RecName: Full=Annexin {ECO:0000256|RuleBase:RU003540}; GN Name=LOC113586946 {ECO:0000313|Ensembl:ENSEEEP00000031781.1}; OS Electrophorus electricus (Electric eel) (Gymnotus electricus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Gymnotiformes; OC Gymnotoidei; Gymnotidae; Electrophorus. OX NCBI_TaxID=8005 {ECO:0000313|Ensembl:ENSEEEP00000031781.1, ECO:0000313|Proteomes:UP000314983}; RN [1] {ECO:0000313|Proteomes:UP000314983} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=24970089; RA Gallant J.R., Traeger L.L., Volkening J.D., Moffett H., Chen P.H., RA Novina C.D., Phillips G.N.Jr., Anand R., Wells G.B., Pinch M., Guth R., RA Unguez G.A., Albert J.S., Zakon H.H., Samanta M.P., Sussman M.R.; RT "Nonhuman genetics. Genomic basis for the convergent evolution of electric RT organs."; RL Science 344:1522-1525(2014). RN [2] {ECO:0000313|Proteomes:UP000314983} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=28695212; RA Traeger L.L., Sabat G., Barrett-Wilt G.A., Wells G.B., Sussman M.R.; RT "A tail of two voltages: Proteomic comparison of the three electric organs RT of the electric eel."; RL Sci. Adv. 3:e1700523-e1700523(2017). RN [3] {ECO:0000313|Ensembl:ENSEEEP00000031781.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2023) to UniProtKB. CC -!- DOMAIN: A pair of annexin repeats may form one binding site for calcium CC and phospholipid. {ECO:0000256|RuleBase:RU003540}. CC -!- SIMILARITY: Belongs to the annexin family. CC {ECO:0000256|ARBA:ARBA00007831, ECO:0000256|RuleBase:RU003540}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A4W4G278; -. DR Ensembl; ENSEEET00000032165.1; ENSEEEP00000031781.1; ENSEEEG00000015058.1. DR GeneTree; ENSGT00940000155770; -. DR Proteomes; UP000314983; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter. DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter. DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter. DR GO; GO:0098641; F:cadherin binding involved in cell-cell adhesion; IEA:TreeGrafter. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW. DR GO; GO:0019834; F:phospholipase A2 inhibitor activity; IEA:TreeGrafter. DR GO; GO:0046632; P:alpha-beta T cell differentiation; IEA:TreeGrafter. DR GO; GO:0050482; P:arachidonic acid secretion; IEA:TreeGrafter. DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:TreeGrafter. DR GO; GO:0071385; P:cellular response to glucocorticoid stimulus; IEA:TreeGrafter. DR GO; GO:0070301; P:cellular response to hydrogen peroxide; IEA:TreeGrafter. DR GO; GO:0035924; P:cellular response to vascular endothelial growth factor stimulus; IEA:TreeGrafter. DR GO; GO:0032508; P:DNA duplex unwinding; IEA:TreeGrafter. DR GO; GO:0031018; P:endocrine pancreas development; IEA:TreeGrafter. DR GO; GO:0042063; P:gliogenesis; IEA:TreeGrafter. DR GO; GO:0071621; P:granulocyte chemotaxis; IEA:TreeGrafter. DR GO; GO:0070365; P:hepatocyte differentiation; IEA:TreeGrafter. DR GO; GO:0006954; P:inflammatory response; IEA:TreeGrafter. DR GO; GO:0030073; P:insulin secretion; IEA:TreeGrafter. DR GO; GO:0030216; P:keratinocyte differentiation; IEA:TreeGrafter. DR GO; GO:0014839; P:myoblast migration involved in skeletal muscle regeneration; IEA:TreeGrafter. DR GO; GO:0045920; P:negative regulation of exocytosis; IEA:TreeGrafter. DR GO; GO:0045629; P:negative regulation of T-helper 2 cell differentiation; IEA:TreeGrafter. DR GO; GO:0097350; P:neutrophil clearance; IEA:TreeGrafter. DR GO; GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; IEA:TreeGrafter. DR GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IEA:TreeGrafter. DR GO; GO:0032743; P:positive regulation of interleukin-2 production; IEA:TreeGrafter. DR GO; GO:0033031; P:positive regulation of neutrophil apoptotic process; IEA:TreeGrafter. DR GO; GO:0031394; P:positive regulation of prostaglandin biosynthetic process; IEA:TreeGrafter. DR GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:TreeGrafter. DR GO; GO:0045627; P:positive regulation of T-helper 1 cell differentiation; IEA:TreeGrafter. DR GO; GO:0031340; P:positive regulation of vesicle fusion; IEA:TreeGrafter. DR GO; GO:0090303; P:positive regulation of wound healing; IEA:TreeGrafter. DR GO; GO:0030850; P:prostate gland development; IEA:TreeGrafter. DR GO; GO:0008360; P:regulation of cell shape; IEA:TreeGrafter. DR GO; GO:0046883; P:regulation of hormone secretion; IEA:TreeGrafter. DR GO; GO:0050727; P:regulation of inflammatory response; IEA:TreeGrafter. DR GO; GO:0032652; P:regulation of interleukin-1 production; IEA:TreeGrafter. DR GO; GO:0002685; P:regulation of leukocyte migration; IEA:TreeGrafter. DR GO; GO:0032355; P:response to estradiol; IEA:TreeGrafter. DR GO; GO:0070555; P:response to interleukin-1; IEA:TreeGrafter. DR GO; GO:0043434; P:response to peptide hormone; IEA:TreeGrafter. DR GO; GO:0010165; P:response to X-ray; IEA:TreeGrafter. DR Gene3D; 1.10.220.10; Annexin; 4. DR InterPro; IPR001464; Annexin. DR InterPro; IPR018502; Annexin_repeat. DR InterPro; IPR018252; Annexin_repeat_CS. DR InterPro; IPR037104; Annexin_sf. DR PANTHER; PTHR10502; ANNEXIN; 1. DR PANTHER; PTHR10502:SF237; ANNEXIN; 1. DR Pfam; PF00191; Annexin; 4. DR PRINTS; PR00196; ANNEXIN. DR SMART; SM00335; ANX; 4. DR SUPFAM; SSF47874; Annexin; 1. DR PROSITE; PS00223; ANNEXIN_1; 3. DR PROSITE; PS51897; ANNEXIN_2; 3. PE 3: Inferred from homology; KW Annexin {ECO:0000256|ARBA:ARBA00023216, ECO:0000256|RuleBase:RU003540}; KW Calcium {ECO:0000256|RuleBase:RU003540}; KW Calcium/phospholipid-binding {ECO:0000256|RuleBase:RU003540}; KW Reference proteome {ECO:0000313|Proteomes:UP000314983}; KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU003540}. SQ SEQUENCE 322 AA; 35736 MW; B8C4AE5928F62DE5 CRC64; MSPSTVSSSC VLLQGKAPSK GSTPPYYGTI TPDPNFSASR DAAALQRAIE AKGVDESAIT EILARRTNAQ RQQIKAAYEN DTGKDLVKTL KSVLKSHYED TVVALLMNPA QYDAYELRQA MKGLGTNEKV LNEILGTRSN HEIRLLKTAF KEGKHPELEH NIKGDTSGHY ETALLALSKT LYEAGEKKIG TVYSVFIDIL TSRSEAQLCK IFKQYDKLGT QGFPKALEHE MKGDVEDCLM TLGKCLRCNS NMVLFECDAL TLQGAWANCN TLTRILVSRS EVDLKKILQE YKRMYGKTLQ EDINVETKGD YVKILLALCG DH //