ID A0A4W3IX93_CALMI Unreviewed; 393 AA. AC A0A4W3IX93; DT 18-SEP-2019, integrated into UniProtKB/TrEMBL. DT 18-SEP-2019, sequence version 1. DT 13-SEP-2023, entry version 15. DE SubName: Full=Dopachrome tautomerase {ECO:0000313|Ensembl:ENSCMIP00000025260.1}; GN Name=dct {ECO:0000313|Ensembl:ENSCMIP00000025260.1}; OS Callorhinchus milii (Ghost shark). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes; OC Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus. OX NCBI_TaxID=7868 {ECO:0000313|Ensembl:ENSCMIP00000025260.1, ECO:0000313|Proteomes:UP000314986}; RN [1] {ECO:0000313|Proteomes:UP000314986} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17185593; DOI=10.1126/science.1130708; RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J., RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L., RA Brenner S.; RT "Ancient noncoding elements conserved in the human genome."; RL Science 314:1892-1892(2006). RN [2] {ECO:0000313|Proteomes:UP000314986} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17407382; RA Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J., RA Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L., RA Brenner S.; RT "Survey sequencing and comparative analysis of the elephant shark RT (Callorhinchus milii) genome."; RL PLoS Biol. 5:E101-E101(2007). RN [3] {ECO:0000313|Proteomes:UP000314986} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=24402279; DOI=10.1038/nature12826; RG International Elephant Shark Genome Sequencing Consortium; RA Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B., RA Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W., RA Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S., RA Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T., RA Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T., RA Wilson R.K., Brenner S., Warren W.C.; RT "Elephant shark genome provides unique insights into gnathostome RT evolution."; RL Nature 505:174-179(2014). RN [4] {ECO:0000313|Ensembl:ENSCMIP00000025260.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Melanosome membrane CC {ECO:0000256|ARBA:ARBA00004573}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004573}. CC -!- SIMILARITY: Belongs to the tyrosinase family. CC {ECO:0000256|ARBA:ARBA00009928}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A4W3IX93; -. DR Ensembl; ENSCMIT00000025673.1; ENSCMIP00000025260.1; ENSCMIG00000011066.1. DR GeneTree; ENSGT00940000156856; -. DR Proteomes; UP000314986; Unassembled WGS sequence. DR GO; GO:0033162; C:melanosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro. DR GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW. DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1. DR InterPro; IPR008922; Di-copper_centre_dom_sf. DR InterPro; IPR002227; Tyrosinase_Cu-bd. DR PANTHER; PTHR11474:SF4; L-DOPACHROME TAUTOMERASE; 1. DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1. DR Pfam; PF00264; Tyrosinase; 1. DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1. DR PROSITE; PS00497; TYROSINASE_1; 1. PE 3: Inferred from homology; KW Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000314986}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 341..367 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 201..218 FT /note="Tyrosinase copper-binding" FT /evidence="ECO:0000259|PROSITE:PS00497" SQ SEQUENCE 393 AA; 44475 MW; E777973CB8CE7668 CRC64; QRHVQIMLCR AGAQFPRACV TVSALLSKQC CPAQGSDPSV LCGAETSRGQ CADVRVDEKP WSGPYNLRNV DDRERWPLKF FNRTCRCTGN FAGYNCAECK FGWIGPNCDL RKPPVTRKNI LSLTPKELQQ FLDALDQAKT TVHPDYVIAT QHWLSLLGLN GTEPQVANVT IYNYFVWLHY YSTRDTLLGP GRPFKGIDFS HRGPAFLTWH RYQLMLLERD LQKLIGNASF ALPYWNFATG RNECDVCTDS LLGSMRPDDP TLINLNSRFS QWEIVCNSLD EYNRLVTLCN GTREGPIRRG LMERGSVKLP TMEDVRSCLS IPEFDTSPYF QNSTFNPDPP LGVILGATFG TAFLGLVLLI LLVMIIAHQR KRRGFEPLIC AEFTPQKYTD EAE //