ID A0A4W2I0B7_BOBOX Unreviewed; 418 AA. AC A0A4W2I0B7; DT 18-SEP-2019, integrated into UniProtKB/TrEMBL. DT 18-SEP-2019, sequence version 1. DT 11-DEC-2019, entry version 4. DE RecName: Full=G_PROTEIN_RECEP_F1_2 domain-containing protein {ECO:0000259|PROSITE:PS50262}; GN Name=ADRB2 {ECO:0000313|Ensembl:ENSBIXP00005037322}; OS Bos indicus x Bos taurus (Hybrid cattle). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=30522 {ECO:0000313|Ensembl:ENSBIXP00005037322}; RN [1] {ECO:0000313|Ensembl:ENSBIXP00005037322} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2019) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|SAAS:SAAS00578748}; CC Multi-pass membrane protein {ECO:0000256|SAAS:SAAS00578748}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000256|RuleBase:RU000688, ECO:0000256|SAAS:SAAS00578773}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSBIXT00005047616; ENSBIXP00005037322; ENSBIXG00005019131. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004941; F:beta2-adrenergic receptor activity; IEA:InterPro. DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:InterPro. DR GO; GO:0097746; P:regulation of blood vessel diameter; IEA:InterPro. DR GO; GO:0006940; P:regulation of smooth muscle contraction; IEA:InterPro. DR InterPro; IPR002233; ADR_fam. DR InterPro; IPR000332; ADRB2_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR PANTHER; PTHR24248:SF21; PTHR24248:SF21; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01103; ADRENERGICR. DR PRINTS; PR00562; ADRENRGCB2AR. DR PRINTS; PR00237; GPCRRHODOPSN. DR SMART; SM01381; 7TM_GPCR_Srsx; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|SAAS:SAAS00578704}; KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688, KW ECO:0000256|SAAS:SAAS00578785}; KW Membrane {ECO:0000256|SAAS:SAAS00578686, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000256|SAAS:SAAS00578729}; KW Transducer {ECO:0000256|RuleBase:RU000688, ECO:0000256|SAAS:SAAS00578707}; KW Transmembrane {ECO:0000256|RuleBase:RU000688, KW ECO:0000256|SAAS:SAAS00578685, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00578784, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 31..58 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 70..96 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 108..129 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 150..169 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 199..219 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 275..295 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 307..327 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 50..326 FT /note="G_PROTEIN_RECEP_F1_2" FT /evidence="ECO:0000259|PROSITE:PS50262" FT REGION 398..418 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 418 AA; 47136 MW; CAB2A18465722B99 CRC64; MGQPGNRSVF LLAPNASHAP DQNVTLERDE AWVVGMGILM SLIVLAIVFG NVLVITAIAK FERLQTVTNY FITSLACADL VMGLAVVPFG ACHILMKMWT FGNFWCEFWT SIDVLCVTAS IETLCVIAVD RYLAITSPFK YQCLLTKNKA RVVILMVWIV SGLTSFLPIQ MHWYRASHKE AINCYAKETC CDFFTNQPYA IASSIVSFYL PLVVMVFVYS RVFQVAKRQL QKIDKSEGRF HAQNVSQVEQ DGRSGLGQRR TSKFYLKEHK ALKTLGIIMG TFTLCWLPFF IVNIVHVIKD NLIRKEIYIL LNWLGYINSA FNPLIYCRSP DFRIAFQELL CLRRSSLKAY GNGCSSNSND RTDYTGEQSG YHLGEEKDSE LLCEDPPGTE NFVNQQGIVP SDSTDSQGRN CSTNDSLL //