ID A0A4W2I0B7_BOBOX Unreviewed; 418 AA. AC A0A4W2I0B7; DT 18-SEP-2019, integrated into UniProtKB/TrEMBL. DT 18-SEP-2019, sequence version 1. DT 13-NOV-2019, entry version 3. DE RecName: Full=G_PROTEIN_RECEP_F1_2 domain-containing protein {ECO:0000259|PROSITE:PS50262}; GN Name=ADRB2 {ECO:0000313|Ensembl:ENSBIXP00005037322}; OS Bos indicus x Bos taurus (Hybrid cattle). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=30522 {ECO:0000313|Ensembl:ENSBIXP00005037322, ECO:0000313|Proteomes:UP000314981}; RN [1] {ECO:0000313|Proteomes:UP000314981} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Low W.Y., Tearle R., Bickhart D.M., Rosen B.D., Koren S., Rhie A., RA Hiendleder S., Phillippy A.M., Smith T.P.L., Williams J.L.; RT "Haplotype-resolved cattle genomes."; RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSBIXP00005037322} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2019) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane CC {ECO:0000256|SAAS:SAAS00578748}; Multi-pass membrane protein CC {ECO:0000256|SAAS:SAAS00578748}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000256|RuleBase:RU000688, ECO:0000256|SAAS:SAAS00578773}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSBIXT00005047616; ENSBIXP00005037322; ENSBIXG00005019131. DR Proteomes; UP000314981; Chromosome 7. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR InterPro; IPR002233; ADR_fam. DR InterPro; IPR000332; ADRB2_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR PANTHER; PTHR24248:SF21; PTHR24248:SF21; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01103; ADRENERGICR. DR PRINTS; PR00562; ADRENRGCB2AR. DR PRINTS; PR00237; GPCRRHODOPSN. DR SMART; SM01381; 7TM_GPCR_Srsx; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|SAAS:SAAS00578704}; KW Complete proteome {ECO:0000313|Proteomes:UP000314981}; KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688, KW ECO:0000256|SAAS:SAAS00578785}; KW Membrane {ECO:0000256|SAAS:SAAS00578686, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|RuleBase:RU000688, KW ECO:0000256|SAAS:SAAS00578729}; KW Transducer {ECO:0000256|RuleBase:RU000688, KW ECO:0000256|SAAS:SAAS00578707}; KW Transmembrane {ECO:0000256|RuleBase:RU000688, KW ECO:0000256|SAAS:SAAS00578685, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00578784, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 31 58 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 70 96 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 108 129 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 150 169 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 199 219 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 275 295 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 307 327 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 50 326 G_PROTEIN_RECEP_F1_2. FT {ECO:0000259|PROSITE:PS50262}. FT REGION 398 418 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. SQ SEQUENCE 418 AA; 47136 MW; CAB2A18465722B99 CRC64; MGQPGNRSVF LLAPNASHAP DQNVTLERDE AWVVGMGILM SLIVLAIVFG NVLVITAIAK FERLQTVTNY FITSLACADL VMGLAVVPFG ACHILMKMWT FGNFWCEFWT SIDVLCVTAS IETLCVIAVD RYLAITSPFK YQCLLTKNKA RVVILMVWIV SGLTSFLPIQ MHWYRASHKE AINCYAKETC CDFFTNQPYA IASSIVSFYL PLVVMVFVYS RVFQVAKRQL QKIDKSEGRF HAQNVSQVEQ DGRSGLGQRR TSKFYLKEHK ALKTLGIIMG TFTLCWLPFF IVNIVHVIKD NLIRKEIYIL LNWLGYINSA FNPLIYCRSP DFRIAFQELL CLRRSSLKAY GNGCSSNSND RTDYTGEQSG YHLGEEKDSE LLCEDPPGTE NFVNQQGIVP SDSTDSQGRN CSTNDSLL //