ID A0A4W2I0B7_BOBOX Unreviewed; 418 AA. AC A0A4W2I0B7; DT 18-SEP-2019, integrated into UniProtKB/TrEMBL. DT 18-SEP-2019, sequence version 1. DT 08-NOV-2023, entry version 20. DE RecName: Full=Beta-2 adrenergic receptor {ECO:0000256|ARBA:ARBA00022188, ECO:0000256|RuleBase:RU368057}; DE Short=Beta-2 adrenoceptor {ECO:0000256|RuleBase:RU368057}; DE AltName: Full=Beta-2 adrenoreceptor {ECO:0000256|ARBA:ARBA00030379, ECO:0000256|RuleBase:RU368057}; GN Name=ADRB2 {ECO:0000313|Ensembl:ENSBIXP00005037322.1}; OS Bos indicus x Bos taurus (Hybrid cattle). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=30522 {ECO:0000313|Ensembl:ENSBIXP00005037322.1, ECO:0000313|Proteomes:UP000429181}; RN [1] {ECO:0000313|Ensembl:ENSBIXP00005037322.1, ECO:0000313|Proteomes:UP000429181} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Low W.Y., Tearle R., Bickhart D.M., Rosen B.D., Koren S., Rhie A., RA Hiendleder S., Phillippy A.M., Smith T.P.L., Williams J.L.; RT "Haplotype-resolved cattle genomes."; RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSBIXP00005037322.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (AUG-2022) to UniProtKB. CC -!- FUNCTION: Beta-adrenergic receptors mediate the catecholamine-induced CC activation of adenylate cyclase through the action of G proteins. The CC beta-2-adrenergic receptor binds epinephrine with an approximately 30- CC fold greater affinity than it does norepinephrine. CC {ECO:0000256|RuleBase:RU368057}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU368057}; CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU368057}. Early CC endosome {ECO:0000256|RuleBase:RU368057}. Golgi apparatus CC {ECO:0000256|RuleBase:RU368057}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Adrenergic receptor subfamily. ADRB2 sub-subfamily. CC {ECO:0000256|RuleBase:RU368057}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A4W2I0B7; -. DR Ensembl; ENSBIXT00005047616.1; ENSBIXP00005037322.1; ENSBIXG00005019131.1. DR GeneTree; ENSGT00940000159538; -. DR OrthoDB; 2900736at2759; -. DR Proteomes; UP000429181; Chromosome 7. DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl. DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell. DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. DR GO; GO:0098992; C:neuronal dense core vesicle; IEA:Ensembl. DR GO; GO:0005634; C:nucleus; IEA:Ensembl. DR GO; GO:0043235; C:receptor complex; IEA:Ensembl. DR GO; GO:0008179; F:adenylate cyclase binding; IEA:Ensembl. DR GO; GO:0001540; F:amyloid-beta binding; IEA:Ensembl. DR GO; GO:0004941; F:beta2-adrenergic receptor activity; IEA:UniProtKB-UniRule. DR GO; GO:0051380; F:norepinephrine binding; IEA:Ensembl. DR GO; GO:0015459; F:potassium channel regulator activity; IEA:Ensembl. DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl. DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl. DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:UniProtKB-UniRule. DR GO; GO:0045453; P:bone resorption; IEA:Ensembl. DR GO; GO:0050873; P:brown fat cell differentiation; IEA:Ensembl. DR GO; GO:1904646; P:cellular response to amyloid-beta; IEA:Ensembl. DR GO; GO:0002024; P:diet induced thermogenesis; IEA:Ensembl. DR GO; GO:0031649; P:heat generation; IEA:Ensembl. DR GO; GO:0040015; P:negative regulation of multicellular organism growth; IEA:Ensembl. DR GO; GO:0045986; P:negative regulation of smooth muscle contraction; IEA:Ensembl. DR GO; GO:0002025; P:norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure; IEA:Ensembl. DR GO; GO:1901098; P:positive regulation of autophagosome maturation; IEA:Ensembl. DR GO; GO:0030501; P:positive regulation of bone mineralization; IEA:Ensembl. DR GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IEA:Ensembl. DR GO; GO:1904504; P:positive regulation of lipophagy; IEA:Ensembl. DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl. DR GO; GO:0061885; P:positive regulation of mini excitatory postsynaptic potential; IEA:Ensembl. DR GO; GO:0010739; P:positive regulation of protein kinase A signaling; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0006898; P:receptor-mediated endocytosis; IEA:Ensembl. DR GO; GO:0002028; P:regulation of sodium ion transport; IEA:Ensembl. DR GO; GO:0009409; P:response to cold; IEA:Ensembl. DR GO; GO:0006939; P:smooth muscle contraction; IEA:Ensembl. DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl. DR CDD; cd15957; 7tmA_Beta2_AR; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR002233; ADR_fam. DR InterPro; IPR000332; ADRB2_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR PANTHER; PTHR24248; ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1. DR PANTHER; PTHR24248:SF21; BETA-2 ADRENERGIC RECEPTOR; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01103; ADRENERGICR. DR PRINTS; PR00562; ADRENRGCB2AR. DR PRINTS; PR00237; GPCRRHODOPSN. DR SMART; SM01381; 7TM_GPCR_Srsx; 1. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|RuleBase:RU368057}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Endosome {ECO:0000256|RuleBase:RU368057}; KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040, KW ECO:0000256|RuleBase:RU000688}; KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034, KW ECO:0000256|RuleBase:RU368057}; KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368057}; KW Receptor {ECO:0000256|RuleBase:RU000688}; KW Transducer {ECO:0000256|RuleBase:RU000688}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000688}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU368057}. FT TRANSMEM 31..58 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU368057" FT TRANSMEM 70..96 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU368057" FT TRANSMEM 108..129 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU368057" FT TRANSMEM 150..169 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU368057" FT TRANSMEM 199..219 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU368057" FT TRANSMEM 275..295 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU368057" FT TRANSMEM 307..327 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU368057" FT DOMAIN 50..326 FT /note="G-protein coupled receptors family 1 profile" FT /evidence="ECO:0000259|PROSITE:PS50262" FT REGION 398..418 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 418 AA; 47136 MW; CAB2A18465722B99 CRC64; MGQPGNRSVF LLAPNASHAP DQNVTLERDE AWVVGMGILM SLIVLAIVFG NVLVITAIAK FERLQTVTNY FITSLACADL VMGLAVVPFG ACHILMKMWT FGNFWCEFWT SIDVLCVTAS IETLCVIAVD RYLAITSPFK YQCLLTKNKA RVVILMVWIV SGLTSFLPIQ MHWYRASHKE AINCYAKETC CDFFTNQPYA IASSIVSFYL PLVVMVFVYS RVFQVAKRQL QKIDKSEGRF HAQNVSQVEQ DGRSGLGQRR TSKFYLKEHK ALKTLGIIMG TFTLCWLPFF IVNIVHVIKD NLIRKEIYIL LNWLGYINSA FNPLIYCRSP DFRIAFQELL CLRRSSLKAY GNGCSSNSND RTDYTGEQSG YHLGEEKDSE LLCEDPPGTE NFVNQQGIVP SDSTDSQGRN CSTNDSLL //